1. Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T

    Current Biology 25(5):671 (2015) PMID 25660545 PMCID PMC4348146

    The kinetochore provides a vital connection between chromosomes and spindle microtubules [1, 2]. Defining the molecular architecture of the core kinetochore components is critical for understanding the mechanisms by which the kinetochore directs chromosome segregation. The KNL1/Mis12 c...
  2. Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T.

    Current Biology 25(5):671 (2015) PMID 25660545 PMCID PMC4348146

    The kinetochore provides a vital connection between chromosomes and spindle microtubules [1, 2]. Defining the molecular architecture of the core kinetochore components is critical for understanding the mechanisms by which the kinetochore directs chromosome segregation. The KNL1/Mis12 complex/Ndc...
  3. Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.

    Molecular Biology of the Cell 25(13):1983 (2014) PMID 24829384 PMCID PMC4072572

    The key player in directing proper chromosome segregation is the macromolecular kinetochore complex, which mediates DNA-microtubule interactions. Previous studies testing individual kinetochore genes documented examples of their overexpression in tumors relative to normal tissue, leading to prop...
  4. Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.

    Molecular Biology of the Cell 25(13):1983 (2014) PMID 24829384 PMCID PMC4072572

    The key player in directing proper chromosome segregation is the macromolecular kinetochore complex, which mediates DNA-microtubule interactions. Previous studies testing individual kinetochore genes documented examples of their overexpression in tumors relative to normal tissue, leading to prop...
  5. Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.

    Molecular Biology of the Cell 25(13):1983 (2014) PMID 24829384 PMCID PMC4072572

    The key player in directing proper chromosome segregation is the macromolecular kinetochore complex, which mediates DNA-microtubule interactions. Previous studies testing individual kinetochore genes documented examples of their overexpression in tumors relative to normal tissue, leading to prop...
  6. Review series: The functions and consequences of force at kinetochores.

    Journal of Cell Biology 200(5):557 (2013) PMID 23460675 PMCID PMC3587826

    Chromosome segregation requires the generation of force at the kinetochore-the multiprotein structure that facilitates attachment of chromosomes to spindle microtubules. This force is required both to move chromosomes and to signal the formation of proper bioriented attachments. To understand th...
  7. Review series: The functions and consequences of force at kinetochores.

    Journal of Cell Biology 200(5):557 (2013) PMID 23460675 PMCID PMC3587826

    Chromosome segregation requires the generation of force at the kinetochore-the multiprotein structure that facilitates attachment of chromosomes to spindle microtubules. This force is required both to move chromosomes and to signal the formation of proper bioriented attachments. To understand th...
  8. CENP-T provides a structural platform for outer kinetochore assembly.

    EMBO Journal 32(3):424 (2013) PMID 23334297 PMCID PMC3567495

    The kinetochore forms a dynamic interface with microtubules from the mitotic spindle during mitosis. The Ndc80 complex acts as the key microtubule-binding complex at kinetochores. However, it is unclear how the Ndc80 complex associates with the inner kinetochore proteins that assemble upon centr...
  9. CENP-T provides a structural platform for outer kinetochore assembly.

    EMBO Journal 32(3):424 (2013) PMID 23334297 PMCID PMC3567495

    The kinetochore forms a dynamic interface with microtubules from the mitotic spindle during mitosis. The Ndc80 complex acts as the key microtubule-binding complex at kinetochores. However, it is unclear how the Ndc80 complex associates with the inner kinetochore proteins that assemble upon centr...