Long-term cardiovascular outcomes and overall survival of early-stage breast cancer patients with early discontinuation of trastuzumab: a population-based study.
Breast Cancer Research and Treatment 157(3):535 (2016)
We critically examined long-term cardiovascular (CV) outcomes and overall survival (OS) of breast cancer (BC) patients who had cardiotoxicity during adjuvant trastuzumab treatment requiring discontinuation in a population-based sample. This was a retrospective cohort of early-stage BC patients d...
Economic Evaluation of Community-Based HIV Prevention Programs in Ontario: Evidence of Effectiveness in Reducing HIV Infections and Health Care Costs.
AIDS and Behavior 20(6):1143 (2016)
Investments in community-based HIV prevention programs in Ontario over the past two and a half decades are assumed to have had an impact on the HIV epidemic, but they have never been systematically evaluated. To help close this knowledge gap, we conducted a macro-level evaluation of investment i...
Hydroxyurea Therapy for Children With Sickle Cell Anemia in Sub-Saharan Africa: Rationale and Design of the REACH Trial.
Pediatric Blood & Cancer 63(1):98 (2016)
Sickle cell anemia (SCA) is an inherited hematological disorder that causes a large but neglected global health burden, particularly in Africa. Hydroxyurea represents the only available disease-modifying therapy for SCA, and has proven safety and efficacy in high-resource countries. In sub-Sahar...
The Temporal Risk of Heart Failure Associated With Adjuvant Trastuzumab in Breast Cancer Patients: A Population Study.
JNCI Journal of the National Cancer Institute 108(1) (2016)
The late cardiac effect of adjuvant trastuzumab and its potential interaction with anthracycline have not been well-studied on a population level.
In this retrospective population-based cohort study, female breast cancer patients in Ontario, diagnosed between 2003 and 2009, were identified by th...
Partial nephrectomy for the treatment of renal cell carcinoma (RCC) and the risk of end-stage renal disease (ESRD).
BJU International 115(6):897 (2015)
To assess whether radical nephrectomy (RN) compared with partial nephrectomy (PN) for the treatment of renal cell carcinoma (RCC) is associated with greater risk of end-stage renal disease (ESRD).
We performed a population-based, retrospective cohort study using linked administrative databases i...
Usefulness of previous methicillin-resistant Staphylococcus aureus screening results in guiding empirical therapy for S aureus bacteremia.
The Canadian journal of infectious diseases = J... 26(4):201 (2015)
Staphylococcus aureus bacteremia (SAB) is an important infection. Methicillin-resistant S aureus (MRSA) screening is performed on hospitalized patients for infection control purposes.
To assess the usefulness of past MRSA screening for guiding empirical antibiotic therapy for SAB.
Workplace-Based Assessment of Internal Medicine Resident Diagnostic Accuracy.
Journal of Graduate Medical Education 6(3):532 (2014)
Making an accurate diagnosis is a core skill residents must develop. Assessments of this skill and decisions to grant residents clinical independence often are based on global impressions. A workplace-based assessment of diagnostic accuracy could be a useful part of a competency-based assessment...
Expert beliefs regarding novel lipid-based approaches to pediatric intestinal failure-associated liver disease.
Journal of Parenteral and Enteral Nutrition 38(6):702 (2014)
To determine expert beliefs regarding the probability of intestinal failure-associated liver disease (IFALD) with novel lipid-based approaches (lipid minimization/ω-3 lipids) in managing IFALD to facilitate Bayesian analyses of clinical trials of these therapies.
Structured interviews were condu...
Evaluation of the measurement properties of the Epworth sleepiness scale: a systematic review.
Sleep Medicine Reviews 18(4):321 (2014)
To examine published evidence on the psychometric properties of the Epworth sleepiness scale (ESS) for describing the level of daytime sleepiness (DS) in adults.
Articles were located on MEDLINE and EMBASE. Psychometric properties were appraised using the COnsensus-based Standards for the select...
Non-biologic remission maintenance therapy in adult patients with ANCA-associated vasculitis: a systematic review and network meta-analysis.
Joint Bone Spine 81(4):337 (2014)
To determine the comparative efficacy of non-biologic treatments for remission maintenance in ANCA-associated vasculitis.
We identified all randomized trials comparing leflunomide, azathioprine, methotrexate or mycophenolate mofetil in adult patients with granulomatosis with polyangiitis or micr...
A pilot phase II RCT of a home-based exercise intervention for survivors of AML.
Supportive Care Cancer 22(4):881 (2014)
Fatigue is the most common and disabling symptom affecting quality of life (QOL) and daily function in patients who have completed treatment for acute myeloid leukemia (AML). Although trials in patients with various solid tumors have reported improved fatigue and QOL following exercise intervent...
Multicenter accuracy and interobserver agreement of spot sign identification in acute intracerebral hemorrhage.
Stroke 45(1):107 (2014)
Rapid, accurate, and reliable identification of the computed tomography angiography spot sign is required to identify patients with intracerebral hemorrhage for trials of acute hemostatic therapy. We sought to assess the accuracy and interobserver agreement for spot sign identification.
A total ...
Development, sensibility, and reliability of the Toronto Axial Spondyloarthritis Questionnaire in inflammatory bowel disease.
Journal of Rheumatology 40(10):1726 (2013)
There is an unacceptable delay in the diagnosis of axial spondyloarthritis (axSpA) in its early stages among patients at high risk, in particular those with inflammatory bowel disease (IBD). Our objectives were to develop a sensible and reliable questionnaire to identify undetected axSpA among p...
A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy.
Leukemia Research 36(10):1255 (2012)
Patients with acute myeloid leukemia (AML) receiving induction chemotherapy (IC) were enrolled in a supervised exercise intervention to determine safety, feasibility, and efficacy. Physical fitness measures, quality of life (QOL) and fatigue were assessed using standardized measures at baseline,...
The association between exit site infection and subsequent peritonitis among peritoneal dialysis patients.
Clinical Journal of the American Society of Nep... 7(8):1266 (2012)
Peritonitis is the most common infectious complication seen in peritoneal dialysis (PD). Traditionally, exit site infection (ESI) has been thought to predispose PD patients to peritonitis, although the risks have not been quantified. This study aimed to quantify the risk of PD peritonitis after ...
Warfarin in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension. A Bayesian approach to evaluating treatment for uncommon disease.
Journal of Rheumatology 39(2):276 (2012)
Warfarin is recommended in systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) and idiopathic PAH (IPAH) to improve survival. There is no evidence to support this in SSc-PAH and the evidence in IPAH is conflicting. We evaluated the ability of warfarin to improve survival usin...
How often are patients with diabetes or hypertension being treated with partial nephrectomy for renal cell carcinoma? A population-based analysis.
BJU International 108(11):1806 (2011)
What's known on the subject? and What does the study add? We know that a major benefit of partial nephrectomy (PN) over radical nephrectomy (RN) is greater preservation of kidney function. Emerging evidence also suggests that chronic kidney disease (CKD) correlates with survival, likely as a res...
A framework for applying unfamiliar trial designs in studies of rare diseases.
Journal of Clinical Epidemiology 64(10):1085 (2011)
Rare diseases may be difficult to study through conventional research methods, but are amenable to study through certain uncommonly used designs. We sought to explain these designs and to provide a framework to assist researchers in identifying the most appropriate design for a given research qu...
The effect of age on the morbidity of kidney surgery.
The Journal of Urology 186(3):811 (2011)
Previous reports of the morbidity of renal surgery have been primarily from academic tertiary referral centers and, thus, they may not reflect general clinical practice. We determined the effect of age and comorbidity on in-hospital surgical morbidity for radical and partial nephrectomy on a pop...
The role of parenteral lipids in the development of advanced intestinal failure-associated liver disease in infants: a multiple-variable analysis.
Journal of Parenteral and Enteral Nutrition 35(5):596 (2011)
Given the recent interest in the role of ω-6 lipids in the development of intestinal failure-associated liver disease (IFALD), the authors sought to examine the role of parenteral lipids in the development of a serum conjugated bilirubin >100 µmol/L (5.9 mg/dL; CB100) in infants.
Between 2003 an...