1. The Cellular and Molecular Basis of Direction Selectivity of Aδ-LTMRs

    Cell 160(5):1027 (2015)

  2. The cellular and molecular basis of direction selectivity of Aδ-LTMRs.

    Cell 159(7):1640 (2014) PMID 25525881 PMCID PMC4297767

    The perception of touch, including the direction of stimulus movement across the skin, begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the skin. Here, we show that murine Aδ-LTMRs are preferentially tuned to deflection of body hairs in the caudal-to-rostral ...
  3. The gentle touch receptors of mammalian skin.

    Science 346(6212):950 (2014) PMID 25414303

    The skin is our largest sensory organ, transmitting pain, temperature, itch, and touch information to the central nervous system. Touch sensations are conveyed by distinct combinations of mechanosensory end organs and the low-threshold mechanoreceptors (LTMRs) that innervate them. Here we explor...
  4. The gentle touch receptors of mammalian skin.

    Science 346(6212):950 (2014) PMID 25414303

    The skin is our largest sensory organ, transmitting pain, temperature, itch, and touch information to the central nervous system. Touch sensations are conveyed by distinct combinations of mechanosensory end organs and the low-threshold mechanoreceptors (LTMRs) that innervate them. Here we explor...
  5. Corrigendum: Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

    Nature Neuroscience 17(12):1840 (2014) PMID 25413093

  6. Qualification of academic facilities for small-scale automated manufacture of autologous cell-based products.

    Regenerative Medicine 9(6):799 (2014) PMID 25431916

    Academic centers, hospitals and small companies, as typical development settings for UK regenerative medicine assets, are significant contributors to the development of autologous cell-based therapies. Often lacking the appropriate funding, quality assurance heritage or specialist regulatory exp...
  7. Enabling ICU patients to die at home.

    Nursing Standard 29(5):46 (2014) PMID 25270483

    There is often an overlap between intensive care medicine and palliative medicine. When all curative treatment options have been explored, keeping the patient comfortable and free from pain is the main concern for healthcare practitioners. Patient autonomy in end of life decisions has not been e...
  8. Enabling ICU patients to die at home.

    Nursing Standard 29(5):46 (2014) PMID 25270483

    There is often an overlap between intensive care medicine and palliative medicine. When all curative treatment options have been explored, keeping the patient comfortable and free from pain is the main concern for healthcare practitioners. Patient autonomy in end of life decisions has not been e...
  9. A tale of two mechanisms: a meta-analytic approach toward understanding the autonomic basis of cardiovascular reactivity to acute psychological stress.

    PMID 24924500

    A series of meta-analyses was undertaken to determine the contributions of sympathetic and parasympathetic activation to cardiovascular stress reactivity. A literature search yielded 186 studies of sufficient quality that measured indices of sympathetic (n = 113) and/or parasympathetic activity ...
  10. Rated and measured impulsivity in children is associated with diminished cardiac reactions to acute psychological stress.

    Biological Psychology 102:68 (2014) PMID 25038303

    This study examined the association between impulsivity and heart rate reactions to a brief psychological stress in pre-adolescent children. Impulsivity was assessed by two response inhibition tasks and maternal self-report. Heart rate was measured at rest and in response to a mental arithmetic ...
  11. Neuroendocrine and cardiovascular reactions to acute psychological stress are attenuated in smokers.

    Psychoneuroendocrinology 48:87 (2014) PMID 24997350

    A number of studies have now examined the association between smoking and the magnitude of physiological reactions to acute psychological stress. However, no large-scale study has demonstrated this association incorporating neuroendocrine in addition to cardiovascular reactions to stress. The pr...
  12. Rated and measured impulsivity in children is associated with diminished cardiac reactions to acute psychological stress

    Biological Psychology 102:68 (2014)

    This study examined the association between impulsivity and heart rate reactions to a brief psychological stress in pre-adolescent children. Impulsivity was assessed by two response inhibition tasks and maternal self-report. Heart rate was measured at rest and in response to a mental a...
  13. Rated and measured impulsivity in children is associated with diminished cardiac reactions to acute psychological stress

    Biological Psychology 102:68 (2014)

    This study examined the association between impulsivity and heart rate reactions to a brief psychological stress in pre-adolescent children. Impulsivity was assessed by two response inhibition tasks and maternal self-report. Heart rate was measured at rest and in response to a mental a...
  14. Rated and measured impulsivity in children is associated with diminished cardiac reactions to acute psychological stress

    Biological Psychology 102:68 (2014)

    This study examined the association between impulsivity and heart rate reactions to a brief psychological stress in pre-adolescent children. Impulsivity was assessed by two response inhibition tasks and maternal self-report. Heart rate was measured at rest and in response to a mental a...
  15. Rated and measured impulsivity in children is associated with diminished cardiac reactions to acute psychological stress

    Biological Psychology 102:68 (2014)

    This study examined the association between impulsivity and heart rate reactions to a brief psychological stress in pre-adolescent children. Impulsivity was assessed by two response inhibition tasks and maternal self-report. Heart rate was measured at rest and in response to a mental a...
  16. Manufacturing models permitting roll out/scale out of clinically led autologous cell therapies: regulatory and scientific challenges for comparability.

    Cytotherapy 16(8):1033 (2014) PMID 24856894

    Manufacturing of more-than-minimally manipulated autologous cell therapies presents a number of unique challenges driven by complex supply logistics and the need to scale out production to multiple manufacturing sites or near the patient within hospital settings. The existing regulatory structur...
  17. Manufacturing models permitting roll out/scale out of clinically led autologous cell therapies: regulatory and scientific challenges for comparability.

    Cytotherapy 16(8):1033 (2014) PMID 24856894

    Manufacturing of more-than-minimally manipulated autologous cell therapies presents a number of unique challenges driven by complex supply logistics and the need to scale out production to multiple manufacturing sites or near the patient within hospital settings. The existing regulatory structur...
  18. Linx mediates interaxonal interactions and formation of the internal capsule.

    Neuron 83(1):93 (2014) PMID 24930700 PMCID PMC4090613

    During the development of forebrain connectivity, ascending thalamocortical and descending corticofugal axons first intermingle at the pallial-subpallial boundary to form the internal capsule (IC). However, the identity of molecular cues that guide these axons remains largely unknown. Here, we s...
  19. Emerging understanding of multiscale tumor heterogeneity.

    Frontiers in Oncology 4:366 (2014) PMID 25566504 PMCID PMC4270176

    Cancer is a multifaceted disease characterized by heterogeneous genetic alterations and cellular metabolism, at the organ, tissue, and cellular level. Key features of cancer heterogeneity are summarized by 10 acquired capabilities, which govern malignant transformation and progression of invasiv...
  20. Rated and measured impulsivity in children is associated with diminished cardiac reactions to acute psychological stress

    Biological Psychology (2014)

    This study examined the association between impulsivity and heart rate reactions to a brief psychological stress in pre-adolescent children. Impulsivity was assessed by two response inhibition tasks and maternal self-report. Heart rate was measured at rest and in response to a mental a...