1. Monitoring B-type natriuretic peptide in patients undergoing therapy with neprilysin inhibitors. An emerging challenge?

    International Journal of Cardiology 219:111 (2016) PMID 27317994

    B-type natriuretic peptide (BNP) is primarily synthesized by the ventricles of the heart as a 108-amino acid polypeptide precursor (i.e., proBNP), which is then cleaved into a 76-amino acid biologically inert N-terminal fragment (NT-proBNP) and a biologically active 32-amino acid peptide (BNP). ...
  2. DNA injury is acutely enhanced in response to increasing bulks of aerobic physical exercise.

    Clinica Chimica Acta 460:146 (2016) PMID 27374303

    The aim of this study was to evaluate DNA damage in response to increasing bulks of aerobic physical exercise. Fifteen adult and trained athletes performed four sequential trials with increasing running distance (5-, 10-, 21- and 42-km) in different periods of the year. The γ-H2AX foci parameter...
  3. The role of European Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase in standardization and harmonization of the preanalytical phase in Europe.

    Annals of Clinical Biochemistry 53(Pt 5):539 (2016) PMID 27141012

    Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry and Labo...
  4. Thirty-minutes' exposure to smartphone call triggers neutrophil activation in vitro.

    Clinical Chemistry and Laboratory Medicine 54(9):1497 (2016) PMID 26872316

    Despite accumulating evidence about the negative health effects of exposure to electromagnetic fields emitted by mobile phones, no information is available on the potential impact of radiofrequency (RF) waves on polymorphonuclear leukocytes biology. Two sequential whole blood tubes were collecte...
  5. The Theranos phenomenon, scientific transparency and freedom of speech.

    Clinical Chemistry and Laboratory Medicine 54(9):1403 (2016) PMID 27442369

  6. Toxic Alcohol Calculations and Misinterpretation of Laboratory Results.

    JAMA Internal Medicine 176(8):1228 (2016) PMID 27479669

  7. Inside out the thrombus: Defining the role of von Willebrand factor.

    Thrombosis Research 144:234 (2016) PMID 27388222

  8. Low serum bilirubin values are associated with pulmonary embolism in a case-control study.

    Clinical Chemistry and Laboratory Medicine 54(8):e229 (2016) PMID 26741350

  9. Short-term Prognosis and Current Management of Syncopal Patients at Intermediate Risk: Results from the IRiS (Intermediate-Risk Syncope) Study.

    Academic Emergency Medicine 23(8):941 (2016) PMID 27178670

    Despite guidelines, admission rates and expenditures for syncope remain high. This may be caused by an imprecise definition of cardiovascular disease considered at risk and an overestimation of the role of comorbidities and advanced age. In a cohort of patients with undetermined syncope, we pros...
  10. Chest pain, dyspnea and other symptoms in patients with type 1 and 2 myocardial infarction. A literature review.

    International Journal of Cardiology 215:20 (2016) PMID 27107538

    Some studies investigated the leading demographic and clinical characteristics of patient with type 2 myocardial infarction (MI), but a comprehensive analysis between type 1 and 2 MI patients is lacking. Therefore, we reviewed current evidence about the difference in clinical signs and symptoms ...
  11. Practices for Identifying and Rejecting Hemolyzed Specimens in Europe.

    Archives of Pathology & Laboratory Medicine 140(7):622 (2016) PMID 27362566

  12. Diagnostics of Inherited Bleeding Disorders of Secondary Hemostasis: An Easy Guide for Routine Clinical Laboratories.

    Seminars in Thrombosis and Hemostasis 42(5):471 (2016) PMID 27071045

    The investigation of inherited bleeding disorders of secondary hemostasis remains a challenge for most clinical laboratories, especially those that lack experience or specialized personnel. Bleeding can be essentially caused by a variety of acquired or congenital conditions, which impair either ...
  13. Energy Drinks and Myocardial Ischemia: A Review of Case Reports.

    Cardiovascular Toxicology 16(3):207 (2016) PMID 26320007

    The use and abuse of energy drinks (EDs) is constantly increasing worldwide. We performed a systematic search in Medline, Scopus and Web of Science to identify evidence about the potential link between these beverages and myocardial ischemia. Overall, 8 case reports could be detected, all of whi...
  14. Red blood cell distribution width independently predicts medium-term mortality and major adverse cardiac events after an acute coronary syndrome.

    Annals of translational medicine 4(13):254 (2016) PMID 27500155 PMCID PMC4958725

    The value of red blood cell distribution width (RDW), a simple and inexpensive measure of anisocytosis, has been associated with the outcome of many human chronic disorders. Therefore, this retrospective study was aimed to investigate whether RDW may be associated with medium-term mortality and ...
  15. No correlation between health care expenditure and mortality in the European Union.

    European Journal of Internal Medicine 32:e13 (2016) PMID 26987418

  16. Improving diagnosis and reducing diagnostic errors: the next frontier of laboratory medicine.

    Clinical Chemistry and Laboratory Medicine 54(7):1117 (2016) PMID 27101552

  17. Patient identification and tube labelling - a call for harmonisation.

    Clinical Chemistry and Laboratory Medicine 54(7):1141 (2016) PMID 26816400

    Venous blood sampling (phlebotomy) is the most common invasive procedure performed in patient care. Guidelines on the correct practice of phlebotomy are available, including the H3-A6 guideline issued by the Clinical Laboratory Standards Institute (CLSI). As the quality of practices and procedur...
  18. Predictive significance of detectable cardiac troponin I measured with a contemporary-sensitive assay in a real life experience.

    Annals of translational medicine 4(13):252 (2016) PMID 27500153 PMCID PMC4958732

    Cardiac troponin (cTn) testing has reduced the likelihood of erroneous discharge of patients with acute coronary syndrome (ACS) from the emergency department (ED), but doubts remain about optimal clinical use. This study was planned for evaluating the predictive significance of cTn values betwee...
  19. High-sensitivity cardiac troponin testing in routine practice: economic and organizational advantages.

    Annals of translational medicine 4(13):257 (2016) PMID 27500158 PMCID PMC4958731

    Very seldom, if ever, a single laboratory test has provided such a paradigm shift in the managed care as cardiac troponin (cTn) testing. More than twenty years of improvements in test design and analytical features have contributed to revolutionize the clinical recommendations and guidelines, an...
  20. Evidence and pitfalls in diagnosis and prognostication of acute coronary syndrome.

    Annals of translational medicine 4(13):250 (2016) PMID 27500152 PMCID PMC4958726