Type 2 treatments for type 1 diabetes.
Journal Of Diabetes 8(5):599 (2016)
Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study.
American Journal of Epidemiology 184(4):295 (2016)
Prolactin plays an important role in maintaining a normal glucose homeostasis during pregnancy and beyond. Studies investigating the association between prolactin and type 2 diabetes beyond pregnancy are rare and none is prospective. We aimed to examine whether prolactin associates with type 2 d...
mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice.
Endocrine 53(1):117 (2016)
Beta cell replication is the major component for maintenance of beta cell mass in adult rodents; however, little is known about what is the earliest signals that initiate rodent beta cell proliferation. The mTORC1 pathway integrates signals from growth factors and nutrients and regulates cell gr...
Optimal cut-off levels of obesity indices by different definitions of metabolic syndrome in a southeast rural Chinese population.
Journal Of Diabetes Investigation 7(4):594 (2016)
The aim of the present study was to compare the cut-off values and prediction effect of different obesity indices by different definitions of metabolic syndrome (MetS) in Zhejiang Province of China.
We carried out a cross-sectional survey of 10,100 individuals (age 40 years and older) in Jiashan...
HLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese.
Journal Of Diabetes Investigation 7(4):514 (2016)
To investigate the typing for human leukocyte antigen (HLA) class I in Chinese patients with type 1 diabetes as a complement screening for HLA class II.
A total of 212 type 1 diabetic patients and 200 healthy controls were enrolled. The genetic polymorphisms of HLA class I and II were examined w...
ERBB-2 overexpression as a risk factor for malignant phaeochromocytomas and paraganglinomas.
Clinical Endocrinology 84(6):822 (2016)
There are currently no good histological or molecular markers to differentiate benign from malignant phaeochromocytomas and paraganglinomas (PPGLs). Our previous cross-sectional study observed that ERBB-2 overexpression was associated with malignant PPGLs. This study aimed to evaluate the predic...
Diabetes and Risk of Arterial Stiffness: A Mendelian Randomization Analysis.
Diabetes 65(6):1731 (2016)
We aimed to explore the causal association between type 2 diabetes (T2D) and increased arterial stiffness. We performed a Mendelian randomization (MR) analysis in 11,385 participants from a well-defined community study in Shanghai during 2011-2013. We genotyped 34 T2D-associated common variants ...
Curbing the obesity epidemic in China.
The lancet. Diabetes & endocrinology 4(6):470 (2016)
Bisphenol A Promotes Adiposity and Inflammation in a Nonmonotonic Dose-response Way in 5-week-old Male and Female C57BL/6J Mice Fed a Low-calorie Diet.
Endocrinology 157(6):2333 (2016)
A growing body of epidemiological research show that Bisphenol A (BPA) is positively correlated with obesity and metabolic disorders. However, the mechanisms of BPA on adiposity remain largely unknown. In this study, we found that 5-week-old male and female C57BL/6J mice exposed to four dosages ...
Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults.
Journal Of Diabetes 8(3):378 (2016)
The aim of the present study was to evaluate the performance of plasma glucose (PG) and HbA1c for the detection of diabetes in the general population in China.
A cross-sectional analysis was conducted in a nationally representative sample of 98,658 Chinese adults aged ≥18 years. Fasting plasma g...
Associations of smoking and alcohol consumption with impaired β-cell function in Chinese men.
Journal Of Diabetes 8(3):434 (2016)
The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion.
A population-based cross-sectional study was per...
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption.
Nature Medicine 22(5):539 (2016)
Tumor necrosis factor (TNF) superfamily member 11 (TNFSF11, also known as RANKL) regulates multiple physiological or pathological functions, including osteoclast differentiation and osteoporosis. TNFRSF11A (also called RANK) is considered to be the sole receptor for RANKL. Herein we report that ...
Sfrp5 mediates glucose-induced proliferation in rat pancreatic β-cells.
Journal of Endocrinology 229(2):73 (2016)
The cellular and molecular mechanisms of glucose-stimulated β-cell proliferation are poorly understood. Recently, secreted frizzled-related protein 5 (encoded by Sfrp5; a Wnt signaling inhibitor) has been demonstrated to be involved in β-cell proliferation in obesity. A previous study demonstrat...
Vildagliptin as add-on therapy to insulin improves glycemic control without increasing risk of hypoglycemia in Asian, predominantly Chinese, patients with type 2 diabetes mellitus.
Journal Of Diabetes 8(3):345 (2016)
The aim of the present study was to investigate the efficacy and safety of vildagliptin added onto insulin with or without metformin in an Asian, predominantly Chinese, population with type 2 diabetes mellitus (T2DM).
In this 24-week, multicenter, double-blind, placebo-controlled trial, patients...
Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.
EBioMedicine 6:162 (2016)
Type 2 diabetes (T2D) is a risk factor for dysregulation of glomerular filtration rate (GFR) and albuminuria. However, whether the association is causal remains unestablished.
We performed a Mendelian Randomization (MR) analysis in 11,502 participants aged 40 and above, from a well-defined commu...
Obesity and peripheral arterial disease: A Mendelian Randomization analysis.
Atherosclerosis 247:218 (2016)
Observational studies showed that obesity is a major risk factor for peripheral arterial disease (PAD). However, conventional epidemiology studies are vulnerable to residual bias from confounding factors. We aimed to explore the causality of obesity in development of PAD using Mendelian Randomiz...
Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus.
Obesity 24(3):703 (2016)
To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife.
This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and mea...
Prevalence of CHD-related metabolic comorbidity of diabetes mellitus in Northern Chinese adults: the REACTION study.
Journal of Diabetes and its Complications 30(2):199 (2016)
To gain more precise understanding of the epidemiology of comorbidities with diabetes and to clarify the correlation with coronary heart disease (CHD) in Chinese population.
Based on REACTION study, 18,696 participants aged over 40 years were included in the cross-sectional analysis. Prevalence ...
Efficacy and safety of linagliptin in Asian patients with type 2 diabetes mellitus inadequately controlled by metformin: A multinational 24-week, randomized clinical trial.
Journal Of Diabetes 8(2):229 (2016)
Despite the increasing prevalence of type 2 diabetes mellitus (T2DM) in Asia, clinical trials for glucose-lowering therapies are often dominated by Caucasian and/or Western populations. The present Phase III randomized placebo-controlled double-blind, 24-week study evaluated the efficacy and saf...
Association of Serum Fetuin-A Levels With the Risk of Albuminuria in Middle-Aged and Elderly Chinese.
Journal of Clinical Endocrinology & Metabolism 101(3):1235 (2016)
Fetuin-A is an important hepatokine associated with many cardiometabolic abnormities. The association between fetuin-A and albuminuria has not been investigated in a prospective cohort.
The objective of the study was to prospectively investigate whether serum fetuin-A levels were associated with...