Discovery and Structural Optimization of N5-Substituted 6,7-Dioxo-6,7-dihydropteridines as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation.
Journal of medicinal and pharmaceutical chemistry 59(15):7111 (2016)
EGFR-targeted inhibitors (gefitinib and erlotinib) provided an effective strategy for the treatment of non-small-cell lung cancer. However, the EGFR T790M secondary mutation has become a leading cause of clinically acquired resistance to these agents. Herein, on the basis of the previously repor...
Contamination characteristics and source apportionment of trace metals in soils around Miyun Reservoir.
Environmental Science and Pollution Research In... 23(15):15331 (2016)
Due to their toxicity and bioaccumulation, trace metals in soils can result in a wide range of toxic effects on animals, plants, microbes, and even humans. Recognizing the contamination characteristics of soil metals and especially apportioning their potential sources are the necessary precondit...
Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence.
Aging Cell 15(3):542 (2016)
Eukaryotic genomes contain transposable elements (TE) that can move into new locations upon activation. Since uncontrolled transposition of TEs, including the retrotransposons and DNA transposons, can lead to DNA breaks and genomic instability, multiple mechanisms, including heterochromatin-medi...
Lamin in inflammation and aging.
Current Opinion in Cell Biology 40:124 (2016)
Aging is characterized by a progressive loss of tissue function and an increased susceptibility to injury and disease. Many age-associated pathologies manifest an inflammatory component, and this has led to the speculation that aging is at least in part caused by some form of inflammation. Howev...
A novel prognostic score model incorporating CDGSH iron sulfur domain2 (CISD2) predicts risk of disease progression in laryngeal squamous cell carcinoma.
Oncotarget 7(16):22720 (2016)
The role of CDGSH iron sulfur domain 2 (CISD2) in laryngeal squamous cell carcinoma (LSCC) remains unclear.
CISD2 were up-regulated in LSCC tissues compared with adjacent noncancerous tissues both at mRNA and protein levels. CISD2 was significantly correlated with T stage, lymph node metastasis,...
Source apportionment of trace metals in river sediments: A comparison of three methods.
Environmental Pollution 211:28 (2016)
Increasing trace metal pollution in river sediment poses a significant threat to watershed ecosystem health. Identifying potential sources of sediment metals and apportioning their contributions are of key importance for proposing prevention and control strategies of river pollution. In this stu...
Contamination characteristics, ecological risk and source identification of trace metals in sediments of the Le'an River (China).
Ecotoxicology and Environmental Safety 125:85 (2016)
Recognizing the pollution characteristics of trace metals in river sediments and targeting their potential sources are of key importance for proposing effective strategies to protect watershed ecosystem health. In this study, a comprehensive investigation was conducted to identify the contaminat...
Source apportionment and health risk assessment of trace metals in surface soils of Beijing metropolitan, China.
Chemosphere 144:1002 (2016)
Understanding the exposure risks of trace metals in contamination soils and apportioning their sources are the basic preconditions for soil pollution prevention and control. In this study, a detailed investigation was conducted to assess the health risks of trace metals in surface soils of Beiji...
Low Prognostic Nutritional Index (PNI) Predicts Unfavorable Distant Metastasis-Free Survival in Nasopharyngeal Carcinoma: A Propensity Score-Matched Analysis.
PLoS ONE 11(7):e0158853 (2016)
Poor nutritional status is associated with progression and advanced disease in patients with cancer. The prognostic nutritional index (PNI) may represent a simple method of assessing host immunonutritional status. This study was designed to investigate the prognostic value of the PNI for distant...
FAT4 functions as a tumour suppressor in gastric cancer by modulating Wnt/β-catenin signalling.
British Journal of Cancer 113(12):1720 (2015)
FAT4, a cadherin-related protein, was shown to function as a tumour suppressor; however, its role in human gastric cancer remains largely unknown. Here, we investigated the role of FAT4 in gastric cancer and examined the underlying molecular mechanisms.
The expression of FAT4 was evaluated by im...
H∞ State Estimation for Discrete-Time Delayed Systems of the Neural Network Type With Multiple Missing Measurements.
Neural Networks and Learning Systems, IEEE Tran... 26(12):2987 (2015)
This paper investigates the H∞ state estimation problem for a class of discrete-time nonlinear systems of the neural network type with random time-varying delays and multiple missing measurements. These nonlinear systems include recurrent neural networks, complex network systems, Lur'e systems, ...
Environmental distribution and associated human health risk due to trace elements and organic compounds in soil in Jiangxi province, China.
Ecotoxicology and Environmental Safety 122:406 (2015)
The government of China launched its first national soil quality and pollution survey (NSQPS) during April 2006 to December 2013. Data gathered in several earlier soil surveys were rarely used to understand the status of pollution. In this study, the dataset collected at the provincial level was...
Low-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis.
Cell Reports 13(7):1505 (2015)
Understanding how chromatin modification regulates development and disease can be limited by available material. Despite recent progress, balancing high-quality and reliable mapping using chromatin-immunoprecipitation-based deep sequencing (ChIP-seq) remains a challenge. We report two techniques...
Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia
Cell 163(1):256 (2015)
Splicing function of mitotic regulators links R-loop-mediated DNA damage to tumor cell killing.
Journal of Cell Biology 209(2):235 (2015)
Although studies suggest that perturbing mitotic progression leads to DNA damage and p53 activation, which in turn lead to either cell apoptosis or senescence, it remains unclear how mitotic defects trigger p53 activation. We show that BuGZ and Bub3, which are two mitotic regulators localized in...
Contamination features and health risk of soil heavy metals in China.
Science of The Total Environment 512-513:143 (2015)
China faces a big challenge of environmental deterioration amid its rapid economic development. To comprehensively identify the contamination characteristics of heavy metals in Chinese soils on a national scale, data set of the first national soil pollution survey was employed to evaluate the po...
Development and External Validation of Nomograms for Predicting Survival in Nasopharyngeal Carcinoma Patients after Definitive Radiotherapy.
Scientific reports 5:15638 (2015)
The distant metastasis free survival (DMFS) and overall survival (OS) differ significantly among individuals even within the same clinical stages. The purpose of this retrospective study was to build nomograms incorporating plasma EBV DNA for predicting DMFS and OS of nasopharyngeal carcinoma (N...
Roles of dopamine receptors and their antagonist thioridazine in hepatoma metastasis.
OncoTargets and Therapy 8:1543 (2015)
Tumor metastasis is the most common cause of death and poor prognosis for cancer patients. Therapeutics that prevent tumor metastasis are the key to prolonging the lifespan of cancer patients. Cancer stem cells are believed to be critical in the metastatic process. Recently, drug screening for c...
Lamin-B in systemic inflammation, tissue homeostasis, and aging.
Nucleus (Austin, Tex. : Print) 6(3):183 (2015)
Gradual loss of tissue function (or homeostasis) is a natural process of aging and is believed to cause many age-associated diseases. In human epidemiology studies, the low-grade and chronic systemic inflammation in elderly has been correlated with the development of aging related pathologies. A...
A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of Twist1 expression.
Molecular Cancer 14(1):186 (2015)
Aberrant expression of A20 has been reported in several human malignancies including hepatocellular carcinoma (HCC). However, its clinical relevance and potential role in HCC remain unknown.
Quantitative PCR, Western blots and immunohistochemistry analyses were used to quantify A20 expression in...