1. Chiral pool synthesis and biological evaluation of C-furanosidic and acyclic LpxC inhibitors.

    European Journal of Medicinal Chemistry 110:340 (2016) PMID 26866455

    Inhibitors of the bacterial deacetylase LpxC have emerged as a promising new class of Gram-negative selective antibacterials. In order to find novel LpxC inhibitors, in chiral-pool syntheses starting from d-mannose, C-furanosides with altered configuration in positions 2 and/or 5 of the tetrahyd...
  2. Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors.

    Organic & Biomolecular Chemistry 11(36):6056 (2013) PMID 23917427

    Inhibitors of the UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) represent promising candidates for the development of antibiotics possessing a so far unexploited mechanism of action. In a chiral pool synthesis, starting from the D-mannose derived mannonolactone 4, confo...
  3. Mining dense Landsat time series for separating cropland and pasture in a heterogeneous Brazilian savanna landscape

    Remote Sensing of Environment 156 (2011)

    Better spatial information on the global distribution of croplands and pastures is urgently needed. Without reliable cropland–pasture separation it will be impossible to retrieve high-quality information on agricultural expansion or land use intensification, and on related ecosystem se...
  4. Land use intensity trajectories on Amazonian pastures derived from Landsat time series

    International Journal of Applied Earth Observat... 41 (2009)

    • Landsat time series were used to reconstruct land use intensity on Amazon pastures. • Dry-season minimum and median tasseled cap wetness relate to woody vegetati...