1. Ruxolitinib versus standard therapy for the treatment of polycythemia vera.

    New England Journal of Medicine 372(17):1670 (2015) PMID 25901433

  2. Association of the blood eosinophil count with hematological malignancies and mortality.

    American Journal of Hematology 90(3):225 (2015) PMID 25488524

    Blood eosinophilia (≥0.5 × 10(9) /l) may be an early sign of hematological malignancy. We investigated associations between levels of blood eosinophils and risks of hematological malignancies and mortality in order to provide clinically derived cut-offs for referral to specialist hematology care...
  3. Expansion of circulating CD56bright natural killer cells in patients with JAK2-positive chronic myeloproliferative neoplasms during treatment with interferon-α.

    Scandinavian Journal of Haematology 94(3):227 (2015) PMID 25082025

    In recent years, major molecular remissions have been observed in patients with JAK2-positive chronic myeloproliferative neoplasms (MPNs) after therapy with IFN-α. IFN-α is known to have altering effects on immune cells involved in immune surveillance and might consequently enhance anti-tumor im...
  4. Association of the blood eosinophil count with hematological malignancies and mortality.

    American Journal of Hematology 90(3):225 (2015) PMID 25488524

    Blood eosinophilia (≥0.5 × 10(9) /l) may be an early sign of hematological malignancy. We investigated associations between levels of blood eosinophils and risks of hematological malignancies and mortality in order to provide clinically derived cut-offs for referral to specialist hematology care...
  5. Expansion of circulating CD56(bright) natural killer cells in patients with JAK2-positive chronic myeloproliferative neoplasms during treatment with interferon-α.

    Scandinavian Journal of Haematology 94(3):227 (2015) PMID 25082025

    In recent years, major molecular remissions have been observed in patients with JAK2-positive chronic myeloproliferative neoplasms (MPNs) after therapy with IFN-α. IFN-α is known to have altering effects on immune cells involved in immune surveillance and might consequently enhance anti-tumor im...
  6. Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state.

    Scandinavian Journal of Haematology 93(3):224 (2014) PMID 24689875

    Chronic myeloproliferative neoplasms (MPN), encompassing essential thrombocythaemia (ET), polycythaemia vera (PV) and myelofibrosis (PMF), are featured by a chronic inflammatory state which is pronounced in myelofibrosis The value of YKL-40 as a biomarker of disease burden has been demonstrated ...
  7. Circulating YKL-40 in myelofibrosis a potential novel biomarker of disease activity and the inflammatory state.

    Scandinavian Journal of Haematology 93(3):224 (2014) PMID 24689875

    Chronic myeloproliferative neoplasms (MPN), encompassing essential thrombocythaemia (ET), polycythaemia vera (PV) and myelofibrosis (PMF), are featured by a chronic inflammatory state which is pronounced in myelofibrosis The value of YKL-40 as a biomarker of disease burden has been demonstrated ...
  8. Perspectives on the impact of JAK-inhibitor therapy upon inflammation-mediated comorbidities in myelofibrosis and related neoplasms.

    Expert Review of Hematology 7(2):203 (2014) PMID 24524202

    Chronic inflammation is suggested to contribute to the Philadelphia-chromosome-negative myeloproliferative neoplasm (MPN) disease initiation and progression, as well as the development of premature atherosclerosis and may drive the development of other cancers in MPNs, both nonhematologic and he...
  9. Perspectives on the impact of JAK-inhibitor therapy upon inflammation-mediated comorbidities in myelofibrosis and related neoplasms.

    Expert Review of Hematology 7(2):203 (2014) PMID 24524202

    Chronic inflammation is suggested to contribute to the Philadelphia-chromosome-negative myeloproliferative neoplasm (MPN) disease initiation and progression, as well as the development of premature atherosclerosis and may drive the development of other cancers in MPNs, both nonhematologic and he...
  10. A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?

    Leukemia Research 38(2):263 (2014) PMID 23932394

    A novel murine model for myeloproliferative neoplasms (MPNs) generated by overexpression of the transcription factor NF-E2 has recently been described. Sustained overexpression of NF-E2 in this model induced myeloid expansion with anemia, leukocytosis and thrombocytosis. Herein, it is debated if...
  11. A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?

    Leukemia Research 38(2):263 (2014)

    A novel murine model for myeloproliferative neoplasms (MPNs) generated by overexpression of the transcription factor NF-E2 has recently been described. Sustained overexpression of NF-E2 in this model induced myeloid expansion with anemia, leukocytosis and thrombocytosis. Herein, it is ...
  12. A phase II study of vorinostat (MK-0683) in patients with primary myelofibrosis and post-polycythemia vera myelofibrosis.

    Haematologica 99(1):e5 (2014) PMID 24425692 PMCID PMC4007932

  13. A phase II study of vorinostat (MK-0683) in patients with primary myelofibrosis and post-polycythemia vera myelofibrosis.

    Haematologica 99(1):e5 (2014) PMID 24425692 PMCID PMC4007932

  14. A phase III randomized trial comparing glucocorticoid monotherapy versus glucocorticoid and rituximab in patients with autoimmune haemolytic anaemia.

    British Journal of Haematology 163(3):393 (2013) PMID 23981017

    The impact of first-line treatment with the anti-CD 20 chimeric monoclonal antibody rituximab in patients with warm-antibody reactive autoimmune haemolytic anaemia (WAIHA) is unknown. We report the first randomized study of 64 patients with newly diagnosed WAIHA who received prednisolone and rit...
  15. A phase III randomized trial comparing glucocorticoid monotherapy versus glucocorticoid and rituximab in patients with autoimmune haemolytic anaemia.

    British Journal of Haematology 163(3):393 (2013) PMID 23981017

    The impact of first-line treatment with the anti-CD 20 chimeric monoclonal antibody rituximab in patients with warm-antibody reactive autoimmune haemolytic anaemia (WAIHA) is unknown. We report the first randomized study of 64 patients with newly diagnosed WAIHA who received prednisolone and rit...
  16. Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes.

    Journal of Immunology 191(8):4059 (2013) PMID 24048901

    Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escheri...
  17. Activated platelets enhance IL-10 secretion and reduce TNF-α secretion by monocytes.

    Journal of Immunology 191(8):4059 (2013) PMID 24048901

    Activated platelets are known to modulate immune responses by secreting or shedding a range of immunomodulatory substances. We examined the influence of activated platelets on cytokine production by normal human mononuclear cells, induced by tetanus toxoid (TT), human thyroglobulin (TG), Escheri...
  18. A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia.

    British Journal of Haematology 162(4):498 (2013) PMID 23758082

    Inhibition of histone deacetylases may be an important target in patients with myeloproliferative neoplasms. This investigator-initiated, non-randomized, open-label phase II multi-centre study included 63 patients (19 essential thrombocythaemia, 44 polycythaemia vera) from 15 centres. The primar...
  19. A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia.

    British Journal of Haematology 162(4):498 (2013) PMID 23758082

    Inhibition of histone deacetylases may be an important target in patients with myeloproliferative neoplasms. This investigator-initiated, non-randomized, open-label phase II multi-centre study included 63 patients (19 essential thrombocythaemia, 44 polycythaemia vera) from 15 centres. The primar...
  20. The role of cytokines in the initiation and progression of myelofibrosis

    Cytokine & Growth Factor Reviews 24(2):133 (2013)

    Myelofibrosis (MF) is a life-threatening blood cancer characterized by progressive bone marrow fibrosis, splenomegaly, cytopenias, and debilitating constitutional symptoms. Abnormal expression and activity of a number of proinflammatory cytokines are associated with MF, in which immune...