1. A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development.

    Blood 125(26):4078 (2015) PMID 25954015 PMCID PMC4481595

    Tissue factor pathway inhibitor (TFPI) is a critical anticoagulant protein present in endothelium and platelets. Mice lacking TFPI (Tfpi(-/-)) die in utero from disseminated intravascular coagulation. They are rescued by concomitant tissue factor (TF) deficiency, demonstrating that TFPI modulate...
  2. Quantitative changes in Gimap3 and Gimap5 expression modify mitochondrial DNA segregation in mice.

    Genetics 200(1):221 (2015) PMID 25808953 PMCID PMC4423365

    Mammalian mitochondrial DNA (mtDNA) is a high-copy maternally inherited genome essential for aerobic energy metabolism. Mutations in mtDNA can lead to heteroplasmy, the co-occurence of two different mtDNA variants in the same cell, which can segregate in a tissue-specific manner affecting the on...
  3. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

    Blood 125(18):2845 (2015) PMID 25733582 PMCID PMC4424632

    Infection and inflammation are invariably associated with activation of the blood coagulation mechanism, secondary to the inflammation-induced expression of the coagulation initiator tissue factor (TF) on innate immune cells. By investigating the role of cell-surface receptors for coagulation fa...
  4. Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation.

    Blood 125(8):1339 (2015) PMID 25575539 PMCID PMC4335085

    Postsurgical peritoneal adhesion bands are the most important causes of intestinal obstruction, pelvic pain, and female infertility. In this study, we used a mouse model of adhesion and compared the protective effect of activated protein C (APC) to that of the Food and Drug Administration-approv...
  5. Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation.

    Blood 125(8):1339 (2015) PMID 25575539 PMCID PMC4335085

    Postsurgical peritoneal adhesion bands are the most important causes of intestinal obstruction, pelvic pain, and female infertility. In this study, we used a mouse model of adhesion and compared the protective effect of activated protein C (APC) to that of the Food and Drug Administration-approv...
  6. Thrombomodulin contributes to gamma tocotrienol-mediated lethality protection and hematopoietic cell recovery in irradiated mice.

    PLoS ONE 10(4):e0122511 (2015) PMID 25860286 PMCID PMC4393275

    Systemic administration of recombinant thrombomodulin (TM) confers radiation protection partly by accelerating hematopoietic recovery. The uniquely potent radioprotector gamma tocotrienol (GT3), in addition to being a strong antioxidant, inhibits the enzyme hydroxy-methyl-glutaryl-coenzyme A red...
  7. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

    Blood 123(24):3706 (2014) PMID 24705491 PMCID PMC4055921

    The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are...
  8. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

    Blood 123(24):3706 (2014) PMID 24705491 PMCID PMC4055921

    The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are...
  9. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

    Blood 123(24):3706 (2014) PMID 24705491 PMCID PMC4055921

    The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are...
  10. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

    Blood 123(24):3706 (2014) PMID 24705491 PMCID PMC4055921

    The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are...
  11. A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.

    Blood 123(24):3706 (2014) PMID 24705491 PMCID PMC4055921

    The cellular source of coagulation factor VIII (FVIII) remains controversial. Like many coagulation proteins, FVIII is produced in the liver, and FVIII synthesis has long been associated with hepatocytes. But extrahepatic synthesis also occurs, and mounting evidence suggests that hepatocytes are...
  12. Inflammation-associated activation of coagulation and immune regulation by the protein C pathway.

    Thrombosis Research 133 Suppl 1:S32 (2014) PMID 24759138 PMCID PMC4060429

    The inflammation-induced activation of the protein C pathway provides negative feedback inhibition of coagulation and exerts coagulation-independent anti-inflammatory and cytoprotective effects. The balance between these activities of aPC modulates the outcome of diverse inflammatory diseases su...
  13. Inflammation-associated activation of coagulation and immune regulation by the protein C pathway.

    Thrombosis Research 133 Suppl 1:S32 (2014) PMID 24759138 PMCID PMC4060429

    The inflammation-induced activation of the protein C pathway provides negative feedback inhibition of coagulation and exerts coagulation-independent anti-inflammatory and cytoprotective effects. The balance between these activities of aPC modulates the outcome of diverse inflammatory diseases su...
  14. A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

    PLoS Neglected Tropical Diseases 8(4):e2819 (2014) PMID 24762740 PMCID PMC3998929

    During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). AP...
  15. A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

    PLoS Neglected Tropical Diseases 8(4):e2819 (2014) PMID 24762740 PMCID PMC3998929

    During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). AP...
  16. A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

    PLoS Neglected Tropical Diseases 8(4):e2819 (2014) PMID 24762740 PMCID PMC3998929

    During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). AP...
  17. A thrombomodulin mutation that impairs active protein C generation is detrimental in severe pneumonia-derived gram-negative sepsis (melioidosis).

    PLoS Neglected Tropical Diseases 8(4):e2819 (2014) PMID 24762740 PMCID PMC3998929

    During severe (pneumo)sepsis inflammatory and coagulation pathways become activated as part of the host immune response. Thrombomodulin (TM) is involved in a range of host defense mechanisms during infection and plays a pivotal role in activation of protein C (PC) into active protein C (APC). AP...
  18. Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.

    Biology Open 4(1):48 (2014) PMID 25505152 PMCID PMC4295165

    In this study, we have identified a novel member of the AMPK family, namely Sucrose non-fermenting related kinase (Snrk), that is responsible for maintaining cardiac metabolism in mammals. SNRK is expressed in the heart, and brain, and in cell types such as endothelial cells, smooth muscle cells...
  19. Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.

    Biology Open 4(1):48 (2014) PMID 25505152

    In this study, we have identified a novel member of the AMPK family, namely Sucrose non-fermenting related kinase (Snrk), that is responsible for maintaining cardiac metabolism in mammals. SNRK is expressed in the heart, and brain, and in cell types such as endothelial cells, smooth muscle cells...
  20. Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism.

    Biology Open 4(1):48 (2014) PMID 25505152

    In this study, we have identified a novel member of the AMPK family, namely Sucrose non-fermenting related kinase (Snrk), that is responsible for maintaining cardiac metabolism in mammals. SNRK is expressed in the heart, and brain, and in cell types such as endothelial cells, smooth muscle cells...