1. Knockdown of phospholipase C-β1 in the medial prefrontal cortex of male mice impairs working memory among multiple schizophrenia endophenotypes.

    Journal of Psychiatry and Neuroscience 40(2):78 (2015) PMID 25268789

    Decreased expression of phospholipase C-β1 (PLC-β1) has been observed in the brains of patients with schizophrenia, but, to our knowledge, no studies have shown a possible association between this altered PLC-β1 expression and the pathogenesis of schizophrenia. Although PLC-β1-null (PLC-β1(-/-)s...
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  2. Intrathecal RGS4 Inhibitor, CCG50014, Reduces Nociceptive Responses and Enhances Opioid-Mediated Analgesic Effects in the Mouse Formalin Test.

    Anesthesia & Analgesia 120(3):671 (2015) PMID 25695583

    The regulator of G-protein signaling protein type 4 (RGS4) accelerates the guanosine triphosphatase activity of Gαi and Gαo, resulting in the inactivation of G-protein-coupled receptor signaling. An opioid receptor (OR), a Gαi-coupled receptor, plays an important role in pain modulation in the c...
  3. Absence of Plateau Potentials in dLGN Cells Leads to a Breakdown in Retinogeniculate Refinement.

    Journal of Neuroscience 35(8):3652 (2015) PMID 25716863 PMCID PMC4339365

    The link between neural activity and the refinement of projections from retina to the dorsal lateral geniculate nucleus (dLGN) of thalamus is based largely on studies that disrupt presynaptic retinogeniculate activity. Postsynaptic mechanisms responsible for implementing the activity-dependent r...
  4. The efficacy and safety of acupuncture for cerebral vasospasm after subarachnoid hemorrhage: study protocol for a randomized controlled trial.

    Trials 16(1):68 (2015) PMID 25886483 PMCID PMC4352281

    Subarachnoid hemorrhage (SAH) is a neurological disease with a high mortality rate. Several serious complications frequently arise after successful surgery for this condition. Cerebral vasospasm, one such complication, occurs in 50 to 70% of SAH patients. These patients suffer neurological sympt...
  5. T-type Ca(2+) channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure.

    Pfluegers Archiv/European Journal of Physiology 466(12):2205 (2014) PMID 24627154

    Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type cha...
  6. T-type Ca(2+) channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure.

    Pfluegers Archiv/European Journal of Physiology 466(12):2205 (2014) PMID 24627154

    Voltage-gated calcium channels are involved in the vascular excitation-contraction mechanism and regulation of arterial blood pressure. It was hypothesized that T-type channels promote formation of nitric oxide from the endothelium. The present experiments determine the involvement of T-type cha...
  7. Gamma Knife radiosurgery for brainstem cavernous malformations: should a patient wait for the rebleed?

    Acta Neurochirurgica 156(10):1937 (2014) PMID 24965071

    The effectiveness of stereotactic radiosurgery (SRS) for cavernous malformation (CM) has not been fully assessed. Consequently, observation is usually recommended when a bleeding CM is initially discovered. Recurrent bleeding occurs with CMs, and these repeat hemorrhages can result in additional...
  8. Gamma Knife radiosurgery for brainstem cavernous malformations: should a patient wait for the rebleed?

    Acta Neurochirurgica 156(10):1937 (2014) PMID 24965071

    The effectiveness of stereotactic radiosurgery (SRS) for cavernous malformation (CM) has not been fully assessed. Consequently, observation is usually recommended when a bleeding CM is initially discovered. Recurrent bleeding occurs with CMs, and these repeat hemorrhages can result in additional...
  9. Gamma Knife radiosurgery for brainstem cavernous malformations: should a patient wait for the rebleed?

    Acta Neurochirurgica 156(10):1937 (2014) PMID 24965071

    The effectiveness of stereotactic radiosurgery (SRS) for cavernous malformation (CM) has not been fully assessed. Consequently, observation is usually recommended when a bleeding CM is initially discovered. Recurrent bleeding occurs with CMs, and these repeat hemorrhages can result in additional...
  10. Clinical analysis and surgical considerations of atherosclerotic cerebral aneurysms: experience of a single center.

    Journal of Cerebrovascular and Endovascular Neu... 16(3):247 (2014) PMID 25340027 PMCID PMC4205251

    Atherosclerotic cerebral aneurysms are known to increase occurrence of thromboembolic events and occlusion of perforator vessels intraoperatively due to pathological changes in the vessels themselves. In the current study, we analyzed the points to be considered during surgery for atheroscleroti...
  11. Flow-related intracranial aneurysms associated with unfused arterial twigs relevant to different vascular anomalies: embryologic and hemodynamic considerations.

    Acta Neurochirurgica 156(9):1637 (2014) PMID 25030267

    Cerebrovascular anomalies resulting from the persistence of unfused embryonic twig-like vessels are associated with intracranial aneurysms. All records of patients with ruptured intracranial aneurysms who were treated at our institution were retrospectively reviewed for the presence of aneurysm-...
  12. Decompressive Surgery in Patients with Poor-grade Aneurysmal Subarachnoid Hemorrhage: Clipping with Simultaneous Decompression Versus Coil Embolization Followed by Decompression.

    Journal of Cerebrovascular and Endovascular Neu... 16(3):254 (2014) PMID 25340028 PMCID PMC4205252

    In addition to obliterating the aneurysm using clipping or coiling, decompressive surgery for control of rising intracranial pressure (ICP) is thought to be crucial to prevention of adverse outcomes in patients with poor grade aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the clinical ...
  13. Endovascular treatment of ruptured distal posterior inferior cerebellar artery aneurysm. Report of two exemplary cases and retrospective analysis of 11 cases.

    Journal of neurological surgery. Part A, Centra... 75(5):343 (2014) PMID 24819627

    Although endovascular therapy for intracranial aneurysms has recently started to replace surgical treatment and literature regarding endovascular therapy's advantages and disadvantages is being published, literature concerning the endovascular treatment of distal posterior inferior cerebellar ar...
  14. Endovascular treatment of ruptured distal posterior inferior cerebellar artery aneurysm. Report of two exemplary cases and retrospective analysis of 11 cases.

    Journal of neurological surgery. Part A, Centra... 75(5):343 (2014) PMID 24819627

    Although endovascular therapy for intracranial aneurysms has recently started to replace surgical treatment and literature regarding endovascular therapy's advantages and disadvantages is being published, literature concerning the endovascular treatment of distal posterior inferior cerebellar ar...
  15. Clinical analysis and surgical considerations of atherosclerotic cerebral aneurysms: experience of a single center.

    Journal of Cerebrovascular and Endovascular Neu... 16(3):247 (2014) PMID 25340027 PMCID PMC4205251

    Atherosclerotic cerebral aneurysms are known to increase occurrence of thromboembolic events and occlusion of perforator vessels intraoperatively due to pathological changes in the vessels themselves. In the current study, we analyzed the points to be considered during surgery for atheroscleroti...
  16. Decompressive Surgery in Patients with Poor-grade Aneurysmal Subarachnoid Hemorrhage: Clipping with Simultaneous Decompression Versus Coil Embolization Followed by Decompression.

    Journal of Cerebrovascular and Endovascular Neu... 16(3):254 (2014) PMID 25340028 PMCID PMC4205252

    In addition to obliterating the aneurysm using clipping or coiling, decompressive surgery for control of rising intracranial pressure (ICP) is thought to be crucial to prevention of adverse outcomes in patients with poor grade aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the clinical ...
  17. Flow-related intracranial aneurysms associated with unfused arterial twigs relevant to different vascular anomalies: embryologic and hemodynamic considerations.

    Acta Neurochirurgica 156(9):1637 (2014) PMID 25030267

    Cerebrovascular anomalies resulting from the persistence of unfused embryonic twig-like vessels are associated with intracranial aneurysms. All records of patients with ruptured intracranial aneurysms who were treated at our institution were retrospectively reviewed for the presence of aneurysm-...
  18. Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.

    PNAS 111(32):11828 (2014) PMID 25071191 PMCID PMC4136605

    Intrinsic burst and rhythmic burst discharges (RBDs) are elicited by activation of T-type Ca(2+) channels in the thalamic reticular nucleus (TRN). TRN bursts are believed to be critical for generation and maintenance of thalamocortical oscillations, leading to the spike-and-wave discharges (SWDs...
  19. Asymptomatic penetration of the oculomotor nerve by a de novo aneurysm associated with severe atherosclerotic stenosis of the supraclinoid internal carotid artery.

    Journal of Korean Neurosurgical Society 56(1):48 (2014) PMID 25289125 PMCID PMC4185319

    A 70-year-old woman presented with headaches and recurrent stroke symptoms. During five years, the patient has been treated for cerebral infarction associated with severe atherosclerotic stenosis of the internal carotid artery. Three-year follow-up magnetic resonance angiography showed a tiny de...
  20. Asymptomatic penetration of the oculomotor nerve by a de novo aneurysm associated with severe atherosclerotic stenosis of the supraclinoid internal carotid artery.

    Journal of Korean Neurosurgical Society 56(1):48 (2014) PMID 25289125 PMCID PMC4185319

    A 70-year-old woman presented with headaches and recurrent stroke symptoms. During five years, the patient has been treated for cerebral infarction associated with severe atherosclerotic stenosis of the internal carotid artery. Three-year follow-up magnetic resonance angiography showed a tiny de...