1. Associations of Insulin and IGFBP-3 with Lung Cancer Susceptibility in Current Smokers.

    JNCI Journal of the National Cancer Institute 108(7) (2016) PMID 27071409

    The epidermal growth factor receptor (EGFR) signaling network is involved in lung carcinogenesis. This study examined whether ligands that activate or suppress the EGFR signaling network were associated with lung cancer risk in ever smokers. A nested case-control study within the Women's Health ...
  2. Comparison of genome-scale DNA methylation profiles in hepatocellular carcinoma by viral status.

    Epigenetics 11(6):464 (2016) PMID 27248055 PMCID PMC4939927

    Hepatocellular carcinoma (HCC) incidence has steadily increased in the US over the past 30 years. Our understanding of epigenetic regulation in HCC is still limited, especially the impact of hepatitis B virus (HBV) or hepatitis C virus (HCV) infection on aberrant DNA methylation. We performed ge...
  3. Insulin/IGF and sex hormone axes in human endometrium and associations with endometrial cancer risk factors.

    Cancer Causes & Control 27(6):737 (2016) PMID 27125830 PMCID PMC4870288

    Experimental and observational data link insulin, insulin-like growth factor (IGF), and estrogens to endometrial tumorigenesis. However, there are limited data regarding insulin/IGF and sex hormone axes protein and gene expression in normal endometrial tissues, and very few studies have examined...
  4. Pan-Cancer Analyses Reveal Long Intergenic Non-Coding RNAs Relevant to Tumor Diagnosis, Subtyping and Prognosis.

    EBioMedicine 7:62 (2016) PMID 27322459 PMCID PMC4909364

    Long intergenic noncoding RNAs (lincRNAs) are a relatively new class of non-coding RNAs that have the potential as cancer biomarkers. To seek a panel of lincRNAs as pan-cancer biomarkers, we have analyzed transcriptomes from over 3300 cancer samples with clinical information. Compared to mRNA, l...
  5. MicroRNA let-7a modifies the effect of self-renewal gene HIWI on patient survival of epithelial ovarian cancer.

    Molecular Carcinogenesis 55(4):357 (2016) PMID 25630839

    Aberrant expressions of self-renewal gene HIWI and microRNA (miRNA) let-7a are observed in epithelial ovarian cancer (EOC). A U-shape association between HIWI expression and overall survival is seen in several human cancers but unknown in EOC. HIWI directly and/or indirectly interacts with let-7...
  6. LIN-28B/let-7a/IGF-II axis molecular subtypes are associated with epithelial ovarian cancer prognosis.

    Gynecologic Oncology 141(1):121 (2016) PMID 26751131

    Aberrant expressions of LIN-28B, let-7a and IGF-II occur in epithelial ovarian cancer, and the LIN-28B/let-7a/IGF-II axis is associated with human disease. The purpose of this study was to investigate the associations between LIN-28B/let-7a/IGF-II axis molecular subtypes and epithelial ovarian c...
  7. Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis.

    Pancreas 45(2):311 (2016) PMID 26646264 PMCID PMC4710562

    While pancreatic cancer (PC) most often affects older adults, to date, there has been no comprehensive assessment of risk factors among PC patients younger than 60 years. We defined early-onset PC (EOPC) and very-early-onset PC (VEOPC) as diagnosis of PC in patients younger than 60 and 45 years,...
  8. PMCA2 regulates HER2 protein kinase localization and signaling and promotes HER2-mediated breast cancer.

    PNAS 113(3):E282 (2016) PMID 26729871 PMCID PMC4725473

    In the lactating mammary gland, the plasma membrane calcium ATPase2 (PMCA2) transports milk calcium. Its expression is activated in breast cancers, where high tumor levels predict increased mortality. We find that PMCA2 expression correlates with HER2 levels in breast cancers and that PMCA2 inte...
  9. A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals.

    Scientific reports 6:28418 (2016) PMID 27344992 PMCID PMC4921829

    Increasing evidences support that metabolically healthy obese (MHO) is a transient state. However, little is known about the early markers associated with the development of metabolic abnormalities in MHO individuals. Serum free fatty acids (FFAs) profile is highlighted in its association with o...
  10. LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer.

    Breast Cancer Research and Treatment 154(3):473 (2015) PMID 26564482 PMCID PMC4854534

    Long non-coding RNAs (lncRNAs) are a class of newly recognized DNA transcripts that have diverse biological activities. Dysregulation of lncRNAs may be involved in many pathogenic processes including cancer. Recently, we found an intergenic lncRNA, LINC00472, whose expression was correlated with...
  11. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.
    Joshua N Sampson, William A Wheeler, Meredith Yeager, Orestis Panagiotou, Zhaoming Wang, Sonja I Berndt, Qing Lan, Christian Abnet, Laufey T Amundadottir, Jonine D Figueroa, Maria Teresa Landi, Lisa Mirabello, Sharon A Savage, Philip R Taylor, Immaculata De Vivo, Katherine A McGlynn, Mark Purdue, Preetha Rajaraman, Hans-Olov Adami, Anders Ahlbom, Demetrius Albanes, Maria Fernanda Amary, She-Juan An, Ulrika Andersson, Gerald Andriole, Irene L Andrulis, Emanuele Angelucci, Stephen M Ansell, Cecilia Arici, Bruce K Armstrong, Alan Arslan, Melissa Austin, Dalsu Baris, Donald A Barkauskas, Bryan A Bassig, Nikolaus Becker, Yolanda Benavente, Simone Benhamou, Christine Berg, David Van Den Berg, Leslie Bernstein, Kimberly A Bertrand, Brenda M Birmann, Amanda Black, Heiner Boeing, Paolo Boffetta, Marie-Christine Boutron-Ruault, Paige M Bracci, Louise Brinton, Angela R Brooks-Wilson, H Bas Bueno-de-Mesquita, Laurie Burdett, Julie Buring, Mary Ann Butler, Qiuyin Cai, Geraldine Cancel-Tassin, Federico Canzian, Alfredo Carrato, Tania Carreon, Angela Carta, John K Chan, Ellen T Chang, Gee-Chen Chang, I-Shou Chang, Jiang Chang, Jenny, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song Chen, Yuh-Min Chen, Li-Hsin Chien, María-Dolores Chirlaque, Jin Eun Choi, Yi Young Choi, Wong-Ho Chow, Charles Chung, Jacqueline Clavel, Françoise, Pierluigi Cocco, Joanne S Colt, Eva Comperat, Lucia Conde, Joseph M Connors, David Conti, Victoria K Cortessis, Michelle Cotterchio, Wendy Cozen, Simon Crouch, Marta Crous-Bou, Olivier Cussenot, Faith G Davis, Ti Ding, W Ryan Diver, Miren Dorronsoro, Laure Dossus, Eric J Duell, Maria Grazia Ennas, Ralph L Erickson, Maria Feychting, Adrienne M Flanagan, Lenka Foretova, Joseph Fraumeni, Neal D Freedman, Laura E Beane Freeman, Charles Fuchs, Manuela Gago-Dominguez, Steven Gallinger, Yu-Tang Gao, Susan M Gapstur, Montserrat Garcia-Closas, Reina García-Closas, Randy D Gascoyne, Julie Gastier-Foster, Mia Gaudet, J Michael Gaziano, Carol Giffen, Graham Giles, Edward Giovannucci, Bengt Glimelius, Michael Goggins, Nalan Gokgoz, Alisa M Goldstein, Richard Gorlick, Myron Gross, Robert Grubb, Jian Gu, Peng Guan, Marc Gunter, Huan Guo, Thomas M Habermann, Christopher A Haiman, Dina Halai, Goran Hallmans, Manal Hassan, Claudia Hattinger, Qincheng He, Xingzhou He, Kathy Helzlsouer, Brian Henderson, Roger Henriksson, Henrik Hjalgrim, Judith Hoffman-Bolton, Chancellor Hohensee, Theodore R Holford, Elizabeth A Holly, Yun-Chul Hong, Robert N Hoover, Pamela L Horn-Ross, G Monawar Hosain, Dean Hosgood, Chin-Fu Hsiao, Nan Hu, Wei Hu, Zhibin Hu, Ming-Shyan Huang, Jose-Maria Huerta, Jen-Yu Hung, Amy Hutchinson, Peter D Inskip, Rebecca D Jackson, Eric Jacobs, Mazda Jenab, Hyo-Sung Jeon, Bu-Tian Ji, Guangfu Jin, Li Jin, Christoffer Johansen, Alison Johnson, Yoo Jin Jung, Rudolph Kaaks, Aruna Kamineni, Eleanor Kane, Chang Hyun Kang, Margaret R Karagas, Rachel S Kelly, Kay-Tee Khaw, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kim, Cari M Kitahara, Alison P Klein, Robert J Klein, Manolis Kogevinas, Takashi Kohno, Laurence N Kolonel, Charles Kooperberg, Anne Kricker, Vittorio Krogh, Hideo Kunitoh, Robert C Kurtz, Kweon, Andrea LaCroix, Charles Lawrence, Fernando Lecanda, Victor Ho Fun Lee, Donghui Li, Haixin Li, Jihua Li, Yao-Jen Li, Yuqing Li, Linda M Liao, Mark Liebow, Tracy Lightfoot, Wei-Yen Lim, Lin, Dongxin Lin, Sara Lindstrom, Martha S Linet, Brian K Link, Chenwei Liu, Jianjun Liu, Li Liu, Börje Ljungberg, Josep Lloreta, Simonetta Di Lollo, Daru Lu, Eiluv Lund, Nuria Malats, Satu Mannisto, Loic Le Marchand, Neyssa Marina, Giovanna Masala, Giuseppe Mastrangelo, Keitaro Matsuo, Marc Maynadie, James McKay, Roberta McKean-Cowdin, Mads Melbye, Beatrice S Melin, Dominique S Michaud, Tetsuya Mitsudomi, Alain Monnereau, Rebecca Montalvan, Lee E Moore, Lotte Maxild Mortensen, Alexandra Nieters, Kari E North, Anne J Novak, Ann L Oberg, Kenneth Offit, In-Jae Oh, Sara H Olson, Domenico Palli, William Pao, In Kyu Park, Jae Yong Park, Kyong Hwa Park, Ana Patiño-Garcia, Sofia Pavanello, Petra H M Peeters, Reury-Perng Perng, Ulrike Peters, Gloria M Petersen, Piero Picci, Malcolm C Pike, Stefano Porru, Jennifer Prescott, Ludmila Prokunina-Olsson, Biyun Qian, You-Lin Qiao, Marco Rais, Elio Riboli, Jacques Riby, Harvey A Risch, Cosmeri Rizzato, Rebecca Rodabough, Eve Roman, Morgan Roupret, Avima M Ruder, Silvia de Sanjose, Ghislaine Scelo, Alan Schned, Fredrick Schumacher, Kendra Schwartz, Molly Schwenn, Katia Scotlandi, Adeline Seow, Consol Serra, Massimo Serra, Howard D Sesso, Veronica Wendy Setiawan, Gianluca Severi, Richard K Severson, Tait D Shanafelt, Hongbing Shen, Wei Shen, Min-Ho Shin, Kouya Shiraishi, Xiao-Ou Shu, Afshan Siddiq, Luis Sierrasesúmaga, Alan Dart Loon Sihoe, Christine F Skibola, Alex Smith, Martyn T Smith, Melissa C Southey, John Spinelli, Anthony Staines, Meir Stampfer, Marianna C Stern, Victoria L Stevens, Rachael S, Jian Su, Wu-Chou Su, Malin Sund, Jae Sook Sung, Sook Whan Sung, Wen Tan, Wei Tang, Adonina Tardón, David Thomas, Carrie A Thompson, Lesley F Tinker, Roberto Tirabosco, Anne Tjønneland, Ruth C Travis, Dimitrios Trichopoulos, Fang-Yu Tsai, Ying-Huang Tsai, Margaret Tucker, Jenny Turner, Claire M Vajdic, Roel C H Vermeulen, Danylo J Villano, Paolo Vineis, Jarmo Virtamo, Kala Visvanathan, Jean, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wang, Fusheng Wei, Elisabete Weiderpass, George J Weiner, Stephanie Weinstein, Nicolas Wentzensen, Emily White, Thomas E Witzig, Brian M Wolpin, Maria Pik Wong, Chen Wu, Guoping Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wu, Jay S Wunder, Yong-Bing Xiang, Jun Xu, Ping Xu, Pan-Chyr Yang, Tsung-Ying Yang, Yuanqing Ye, Zhihua Yin, Jun Yokota, Ho-Il Yoon, Chong-Jen Yu, Herbert Yu, Kai Yu, Jian-Min Yuan, Andrew Zelenetz, Anne Zeleniuch-Jacquotte, Xu-Chao Zhang, Yawei Zhang, Xueying Zhao, Zhenhong Zhao, Hong Zheng, Tongzhang Zheng, Wei Zheng, Baosen Zhou, Meng Zhu, Mariagrazia Zucca, Simina M Boca, James R Cerhan, Giovanni M Ferri, Patricia Hartge, Chao Agnes Hsiung, Corrado Magnani, Lucia Miligi, Lindsay Morton, Karin E Smedby, Lauren R Teras, Joseph Vijai, Sophia Wang, Paul Brennan, Neil E Caporaso, David J Hunter, Peter Kraft, Nathaniel Rothman, Debra T Silverman, Susan L Slager, Stephen J Chanock, and Nilanjan Chatterjee

    JNCI Journal of the National Cancer Institute 107(12):djv279 (2015) PMID 26464424 PMCID PMC4806328

    Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. Between 2007 ...
  12. Lowered circulating aspartate is a metabolic feature of human breast cancer.

    Oncotarget 6(32):33369 (2015) PMID 26452258 PMCID PMC4741772

    Distinct metabolic transformation is essential for cancer cells to sustain a high rate of proliferation and resist cell death signals. Such a metabolic transformation results in unique cellular metabolic phenotypes that are often reflected by distinct metabolite signatures in tumor tissues as we...
  13. Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals.

    EBioMedicine 2(10):1513 (2015) PMID 26629547 PMCID PMC4634820

    Obesity is not a homogeneous condition across individuals since about 25-40% of obese individuals can maintain healthy status with no apparent signs of metabolic complications. The simple anthropometric measure of body mass index does not always reflect the biological effects of excessive body f...
  14. Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer.

    Nature Genetics 47(8):911 (2015) PMID 26098869 PMCID PMC4520746

    Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To i...
  15. Risch et al. Respond to "Clinical Utility of Prediction Models for Rare Outcomes: The Example of Pancreatic Cancer".

    American Journal of Epidemiology 182(1):39 (2015) PMID 26049861

  16. Detectable Symptomatology Preceding the Diagnosis of Pancreatic Cancer and Absolute Risk of Pancreatic Cancer Diagnosis.

    American Journal of Epidemiology 182(1):26 (2015) PMID 26049860 PMCID PMC4479115

    The survival duration for pancreatic cancer is short. Given its low lifetime risk (1.5%), established factors for the disease have insufficient specificity to identify individuals at high risk of nonfamilial cancer, and prediagnostic signs and symptoms are vague and not limited to pancreatic cau...
  17. MiR-195 suppresses non-small cell lung cancer by targeting CHEK1.

    Oncotarget 6(11):9445 (2015) PMID 25840419 PMCID PMC4496229

    MiR-195 suppresses tumor growth and is associated with better survival outcomes in several malignancies including non-small cell lung cancer (NSCLC). Our previous study showed high miR-195 plasma levels associated with favorable overall survival of non-smoking women with lung adenocarcinoma. To ...
  18. Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer.

    Oncotarget 6(11):8579 (2015) PMID 25865225 PMCID PMC4496168

    LINC00472 is a novel long intergenic non-coding RNA. We evaluated LINC00472 expression in breast tumor samples using RT-qPCR, performed a meta-analysis of over 20 microarray datasets from the Gene Expression Omnibus (GEO) database, and investigated the effect of LINC00472 expression on cell prol...
  19. Intrauterine devices and endometrial cancer risk: a pooled analysis of the Epidemiology of Endometrial Cancer Consortium.

    International Journal of Cancer 136(5):E410 (2015) PMID 25242594 PMCID PMC4267918

    Intrauterine devices (IUDs), long-acting and reversible contraceptives, induce a number of immunological and biochemical changes in the uterine environment that could affect endometrial cancer (EC) risk. We addressed this relationship through a pooled analysis of data collected in the Epidemiolo...
  20. Disease risk estimation by combining case-control data with aggregated information on the population at risk.

    Biometrics 71(1):114 (2015) PMID 25351292 PMCID PMC4782587

    We propose a novel statistical framework by supplementing case-control data with summary statistics on the population at risk for a subset of risk factors. Our approach is to first form two unbiased estimating equations, one based on the case-control data and the other on both the case data and ...