1. Electrophysiological properties of brain-natriuretic peptide- and gastrin-releasing peptide-responsive dorsal horn neurons in spinal itch transmission.

    Neuroscience Letters 627:51 (2016) PMID 27235577

    Spinal itch transmission has been reported to be mediated by at least two neuronal populations in spinal dorsal horn, neurons expressing brain-natriuretic peptide (BNP) receptor (Npra) and gastrin-releasing peptide (GRP) receptor (GRPR). Although Npra-expressing neurons were shown to be upstream...
  2. Sumoylated α-skeletal muscle actin in the skeletal muscle of adult rats.

    Molecular and Cellular Biochemistry 409(1-2):59 (2015) PMID 26169987

    Skeletal muscles are composed of two major muscle fiber types: slow-twitch oxidative fibers and fast-twitch glycolytic fibers. The proteins in these muscle fibers are known to differ in their expression, relative abundance, and post-translational modifications. In this study, we report a previou...
  3. Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.

    Molecular Brain 8(1):38 (2015) PMID 26104314 PMCID PMC4477293

    Guanine nucleotide exchange factors (GEFs) activate small GTPases that are involved in several cellular functions. cAMP-guanine nucleotide exchange factor II (cAMP-GEF II) acts as a target for cAMP independently of protein kinase A (PKA) and functions as a GEF for Rap1 and Rap2. Although cAMP-GE...
  4. Importance of tryptophan nitration of carbonic anhydrase III for the morbidity of atopic dermatitis.

    Free Radical Biology and Medicine 73:75 (2014) PMID 24838180

    The nitration of proteins results from the vigorous production of reactive nitrogen species in inflammatory disease. We previously reported the proteomic analysis of nitrated tryptophan residues in in vitro model cells for inflammatory diseases using a 6-nitrotryptophan-specific antibody. In thi...
  5. A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole for the treatment of acute manic or mixed episodes in Asian patients with bipolar I disorder (the AMAZE study).

    World Journal of Biological Psychiatry 15(2):113 (2014) PMID 22540407

    To investigate the efficacy and safety of aripiprazole in Asian patients with manic or mixed episodes associated with bipolar I disorder. Subjects were randomised to aripiprazole (24 mg/day; reduced to 12 mg/day if needed for tolerability; n = 128) or placebo (n = 130) for 3 weeks in this multic...
  6. PSS216 - Proteomic Analysis for Identification of 6-NO2Trp Containing Proteins in Stroke-Prone Spontaneously Hypertensive Rat, SHRSP

    Free Radical Biology and Medicine 65:S99 (2013)

  7. PSS99 - Peroxynitrous Acid Mediated Oxidation of Fibronectin Affects Protein Structure and Compromises Endothelial Cell Binding

    Free Radical Biology and Medicine 65:S53 (2013)

  8. PSS236 - Presence of Nitrotryptophan-Containing Proteins in the Adult Rat1 Skeletal Muscle

    Free Radical Biology and Medicine 65:S106 (2013)

  9. Peroxynitrite-mediated damage in the artery wall and its consequences-SESSION 4

    Free Radical Biology and Medicine 65:S6 (2013)

  10. Identification of nitrotryptophan-containing proteins in the lesional skin of atopic NC/Nga mice

    Journal of Dermatological Science 69(2):e15 (2013)

  11. Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.

    Frontiers in Behavioral Neuroscience 7:17 (2013) PMID 23487260 PMCID PMC3594921

    The habenular complex linking forebrain and midbrain structures is subdivided into the medial (mHb) and the lateral nuclei (lHb). The mHb is characterized by the expression of specific nicotinic acetylcholine receptor isoforms and the release of acetylcholine to the interpeduncular nucleus (IPN)...
  12. [Recommendations for ECT Practice, Second Edition].

    Seishin shinkeigaku zasshi = Psychiatria et neu... 115(6):586 (2013) PMID 23944116

  13. Proteomic analysis of endogenous nitrotryptophan-containing proteins in rat hippocampus and cerebellum.

    Bioscience Reports 32(6):521 (2012) PMID 22697601 PMCID PMC3475453

    Nitration of tryptophan residues is a novel post-translational modification. In the present study, we examined whether NO2Trp (nitrotryptophan)-containing proteins are produced in the hippocampus and cerebellum of the adult rat under physiological conditions in vivo. Using Western blot analysis ...
  14. Formation of nitrated tryptophan residues as a novel post-translational modification in the physiological state

    Nitric Oxide 27:S36 (2012)

    Protein nitration is a post-translational modification that is induced by reactive nitrogen species (RNS) such as peroxynitrite (ONOO−) and nitrogen dioxide (NO2). Nitration of tyrosine residues in proteins has been studied extensively and found in many diseases under oxidative stress....
  15. Epigenetics in cancer and inflammation

    Personalized Medicine Universe 1(1):7 (2012)

    Purpose Epigenetics has a critical role in various events in both normal development and human disease. DNA methylation, a major epigenetic modification, regulates gene expression at the transcriptional level. In this review, to understand epigenetics we focus on DNA methylat...
  16. The role of cAMP-GEF II/RapGEF4/Epac2 in neural function related to memory and impulsive behavior

    Neuroscience Research 71:e181 (2011)

  17. Nitration of tryptophan in ribosomal proteins is a novel post-translational modification of differentiated and naïve PC12 cells.

    Nitric Oxide 25(2):176 (2011) PMID 21642007

    Neuron growth factor (NGF) signaling in PC12 cell, which is derived from pheochromocytoma of rat adrenal medulla, induces expression of neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) production. Subsequently, NO causes differentiation of PC12 cell to neuronal cell with morphological...
  18. Nominal association between a polymorphism in DGKH and bipolar disorder detected in a meta-analysis of East Asian case-control samples.

    Psychiatry and Clinical Neurosciences 65(3):280 (2011) PMID 21507135

    Recent genome-wide association studies (GWAS) of bipolar disorder (BD) have detected new candidate genes, including DGKH, DFNB31 and SORCS2. However, the results of these GWAS were not necessarily consistent, indicating the importance of replication studies. In this study, we tested the genetic ...
  19. Mass spectrometric identification of tryptophan nitration sites on proteins in peroxynitrite-treated lysates from PC12 cells.

    Free Radical Biology and Medicine 50(3):419 (2011) PMID 21108999

    One of the important sites of peroxynitrite action that affects cellular function is known to be nitration of tyrosine residues. However, tryptophan residues could be another target of peroxynitrite-dependent modification of protein function, as we have shown previously using a model protein (F....
  20. Glyceraldehyde-3-phosphate dehydrogenase interacts with phosphorylated Akt resulting from increased blood glucose in rat cardiac muscle.

    FEBS Letters 584(13):2796 (2010) PMID 20488185

    Here we describe the interaction of phosphorylated approximately 40 kDa protein with phosphorylated Akt which is a serine/threonine kinase resulting from increased blood glucose in rat cardiac muscle. Mass spectrometry analysis revealed that this protein was glyceraldehyde-3-phosphate dehydrogen...