1. Quantitative CT analysis of honeycombing area in idiopathic pulmonary fibrosis: Correlations with pulmonary function tests.

    European Journal of Radiology 85(1):125 (2016) PMID 26724656

    The 2011 official statement of idiopathic pulmonary fibrosis (IPF) mentions that the extent of honeycombing and the worsening of fibrosis on high-resolution computed tomography (HRCT) in IPF are associated with the increased risk of mortality. However, there are few reports about the quantitativ...
  2. Thoracolithiasis diagnosed by thoracoscopy under local anesthesia.

    RESPIROLOGY CASE REPORTS 3(3):102 (2015) PMID 26392857 PMCID PMC4571739

    A 68-year-old woman was referred to our hospital for a lung nodule identified on chest radiography. Computed tomography (CT) showed a 10-mm calcified nodule in the left thoracic cavity. On follow-up CT, the nodule was found in a different location within the left thoracic cavity. Thoracoscopy wa...
  3. A mixed phenotype of airway wall thickening and emphysema is associated with dyspnea and hospitalization for chronic obstructive pulmonary disease.

    Annals of the American Thoracic Society 12(7):988 (2015) PMID 25844673

    Quantitative computed tomography (CT) has been used to phenotype patients with chronic obstructive pulmonary disease (COPD). A mixed phenotype is defined as the presence of both airway wall thickening and emphysema on quantitative CT. Little is known about patients with COPD with the mixed pheno...
  4. Mediastinitis and pericarditis after endobronchial ultrasound-guided transbronchial needle aspiration.

    RESPIROLOGY CASE REPORTS 3(1):16 (2015) PMID 25802743 PMCID PMC4364792

    A 73-year-old man was admitted to our hospital for further investigation of multiple lung nodules and lymphadenopathy that were observed on chest radiography. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was performed to sample the lower paratracheal lymph node (4...
  5. Behavioral Changes in General Practitioners towards Chronic Obstructive Pulmonary Disease Over Five Years: An Observational Study.

    Internal Medicine (Tokyo, 1992) 54(14):1705 (2015) PMID 26193803

    Early detection of chronic obstructive pulmonary disease (COPD) is critical for preventing progression; however, the disease is rarely detected in the early stages. One reason for this is that COPD is not generally recognized and diagnosed by general practitioners (GPs). The objective of this st...
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  6. Ehlers-Danlos Syndrome Type IV with Bilateral Pneumothorax.

    Internal Medicine (Tokyo, 1992) 54(24):3181 (2015) PMID 26666608

    A 17-year-old teen was hospitalized with bilateral pneumothorax. After the bilateral lungs were expanded using catheter tubes, he fully recovered and he was discharged from our hospital. He had a history of colon perforation. Ehlers-Danlos syndrome (EDS) was suspected due to the combination of c...
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  7. Airway wall area derived from 3-dimensional computed tomography analysis differs among lung lobes in male smokers.

    PLoS ONE 9(5):e98335 (2014) PMID 24865661 PMCID PMC4035347

    It is time-consuming to obtain the square root of airway wall area of the hypothetical airway with an internal perimeter of 10 mm (√Aaw at Pi10), a comparable index of airway dimensions in chronic obstructive pulmonary disease (COPD), from all airways of the whole lungs using 3-dimensional compu...
  8. Determination of 22 ginsenosides in ginseng products using ultra-high-performance liquid chromatography.

    Journal of Chromatographic Science 51(4):355 (2013) PMID 22977120

    A reverse-phase ultra-high-performance liquid chromatography (u-HPLC) method was developed for the rapid quantification of 22 ginsenosides in ginseng products. The proposed method for the analysis of ginsenosides is based on a heating-block method without further treatment. The u-HPLC separation...
  9. An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor.

    Nature Chemical Biology 9(3):160 (2013) PMID 23314914

    We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetrade...
  10. Simultaneous determination of free capsorubin and capsanthin in red pepper powder using u-HPLC.

    Journal of AOAC International 96(2):341 (2013) PMID 23767359

    A simultaneous ultra-HPLC (u-HPLC) method for the determination of free capsorubin and capsanthin in red pepper powder was validated in terms of its precision, accuracy, and linearity. The u-HPLC separation was performed on an RP C18 column (particle size 2 pm, id 2 mm length 100 mm) and with a ...
  11. Rapid method for the simultaneous determination of flavonol aglycones in food using u-HPLC coupled with heating block acidic hydrolysis.

    Journal of AOAC International 96(5):1059 (2013) PMID 24282947

    A rapid method for the simultaneous determination of flavonol aglycones in food using ultra-high-performance LC (u-HPLC) coupled with a heating-block acidic hydrolysis method was validated in terms of precision, accuracy, and linearity. The u-HPLC separation was performed on an RP C18 column (pa...
  12. Rapid method for the determination of vitamins A and E in foods using ultra-high-performance liquid chromatography.

    Journal of AOAC International 95(2):517 (2012) PMID 22649940

    A rapid and novel ultra-HPLC (u-HPLC) method for the determination of vitamins A (retinol) and E (alpha-, gamma-, and delta-tocopherol) in foods was validated in terms of its precision, accuracy, and linearity. The u-HPLC separation was performed on an RP C18 column (particle size 2 microm, id 2...
  13. The clinical characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis.

    Internal Medicine (Tokyo, 1992) 51(24):3405 (2012) PMID 23257529

    We herein report the clinical and laboratory characteristics of two anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibody-positive interstitial lung disease patients with polymyositis/dermatomyositis (PM/DM). We compared these characteristics with previously published findings. Previous reports ...
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  14. Alterations of high-mannose type N-glycosylation in human and mouse osteoarthritis cartilage.

    Arthritis & Rheumatism 63(11):3428 (2011) PMID 21834068

    The process of N-glycosylation is involved in the pathogenesis of various diseases. However, little is known about the contribution of changes in N-glycans in osteoarthritis (OA). The aim of this study was to identify the alterations in N-glycans in human OA cartilage, to characterize the messen...
  15. [Four cases of respiratory infections caused by Legionella pneumophila serogroup 3].

    Kansenshogaku zasshi. The Journal of the Japane... 85(4):373 (2011) PMID 21861442

    Legionella pneumonia tends to be severe and is known to be fatal. Introduction of the urinary Legionella antigen test and changes in the Infectious Disease Law have led to increased numbers of reports, and milder cases are now occasionally seen. We experienced three cases demonstrating mild resp...
  16. Validation of scoring systems for predicting severe community-acquired pneumonia.

    Internal Medicine (Tokyo, 1992) 50(18):1917 (2011) PMID 21921369

    Several scoring systems have been derived to identify patients with severe community-acquired pneumonia (CAP). Recently, España et al (Am J Respir Crit Care Med 174:1249-1256, 2006) developed a clinical prediction rule that predicts hospital mortality, the need for mechanical ventilation, and ri...
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  17. [Clinical evaluation of bedridden patients with pneumonia receiving home health care].

    Nihon Kokyuki Gakkai zasshi = the journal of th... 48(12):906 (2010) PMID 21226296

    Pneumonia which develops in patients while living in their own home is categorized as community-acquired pneumonia (CAP), even if these patients are bedridden and receiving home health care. However, because of the differences in patient backgrounds, we speculated that the clinical outcomes and ...
  18. [Clinical investigation of postinfectious cough among adult patients with prolonged cough].

    Nihon Kokyuki Gakkai zasshi = the journal of th... 48(3):179 (2010) PMID 20387520

    To prospectively investigate the incidence and clinical findings of "postinfectious cough" among adult patients with prolonged cough, enrolled from July 2006 to June 2008, we studied the serum antibodies of Mycoplasma pneumoniae, Chlamydophila pneumoniae and Bordetella pertussis in those who com...
  19. Rapid method for the determination of capsaicin and dihydrocapsaicin in Gochujang using ultra-high-performance liquid chromatography.

    Journal of AOAC International 93(6):1905 (2010) PMID 21313819

    A sensitive and specific heating block method coupled with ultra-HPLC (u-HPLC) was developed for the analysis of capsaicin in Gochujang and validated by comparing with a conventional HPLC (AOAC Method 995.03). The method validation parameters yielded good results, including linearity, precision,...
  20. Analysis of saccharides possessing post-translational protein modifications by phenylhydrazine labeling using high-performance liquid chromatography.

    Analytical Sciences 25(8):1039 (2009) PMID 19667484

    Sugar analysis by postcolumn labeling using phenylhydrazine with high-performance liquid chromatography is herein introduced. Phenylhydrazine reacts not only with the reducing end of oligosaccharides, but also with mono-sugar components with degraded glycosyl bonds. N-acethylhexosamine is highly...