1. Caffeine fostering of mycoparasitic fungi against phytopathogens.

    Plant Signaling & Behavior 11(1):e1113362 (2016) PMID 26529400 PMCID PMC4871636

    Caffeine (1,3,7-trimethixanthine) is a typical purine alkaloid produced in more than 80 plant species. Its biological role is considered to strengthen plant's defense capabilities, directly as a toxicant to biotic attackers (allelopathy) and indirectly as an activator of defense system (priming)...
  2. Japanese public long-term care insured: preferences for future long-term care facilities, including relocation, waiting times, and individualized care.

    Journal of the American Medical Directors Assoc... 16(4):350.e9 (2015) PMID 25732833

    Expenditures on long-term care insurance (LTCI) in Japan have been increasing with the aging of the population, which has led to an increase in premiums. To optimize resource allocation, we aim to clarify the priorities of the functions of long-term care facilities from the viewpoint of future b...
  3. Safety and feasibility of adjuvant chemotherapy with S-1 in Japanese breast cancer patients after primary systemic chemotherapy: a feasibility study.

    BMC Cancer 15:253 (2015) PMID 25884795 PMCID PMC4407316

    Advanced breast cancer patients have a higher risk of postoperative recurrence than early-stage breast cancer patients. Recurrence is believed to be caused by the increase in micrometases, which were not eradicated by preoperative or postoperative chemotherapy. Therefore, a new therapeutic strat...
  4. Contribution of bone marrow-derived mesenchymal stem cells to the morphological changes in the bladder after partial outlet obstruction: a preliminary study.

    International Journal of Urology 21(7):714 (2014) PMID 24588792

    To investigate the contribution of bone marrow-derived mesenchymal stem cells to the changes in bladder morphology in response to partial bladder outlet obstruction. Allogenic bone marrow cells were transplanted from transgenic rats expressing green fluorescent protein into female Sprague-Dawley...
  5. Clinicopathological and prognostic impact of imaging of breast cancer angiogenesis and hypoxia using diffuse optical spectroscopy.

    Cancer Science 105(7):833 (2014) PMID 24766271 PMCID PMC4317930

    Near-infrared diffuse optical spectroscopy (DOS) imaging can non-invasively measure tumor hemoglobin concentration using high contrast to normal tissue, thus providing vascularity and oxygenation status. We assessed the clinical usefulness of DOS imaging in primary breast cancer. In all, 118 wom...
  6. What is the most effective strategy for improving the cancer screening rate in Japan?

    Asian Pacific journal of cancer prevention : APJCP 15(6):2607 (2014) PMID 24761871

    Cancer screening rates in Japan are much lower than those in Western countries. This study evaluated the relationship between cancer screening rates and strategies used to improve screening rates, and determined which strategy is the most effective. All municipalities are responsible for conduct...
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  7. Optical imaging for monitoring tumor oxygenation response after initiation of single-agent bevacizumab followed by cytotoxic chemotherapy in breast cancer patients.

    PLoS ONE 9(6):e98715 (2014) PMID 24905225 PMCID PMC4048242

    Optical imaging techniques for measuring tissue hemoglobin concentration have been recently accepted as a way to assess tumor vascularity and oxygenation. We investigated the correlation between early optical response to single-agent bevacizumab and treatment outcome. Seven patients with advance...
  8. Genomic profiling shows increased glucose metabolism in luminal B breast cancer.

    Journal of Breast Cancer 16(3):342 (2013) PMID 24155765 PMCID PMC3800732

    We had previously reported a close association between pathological response and the maximum tumor standardized uptake value (SUVmax) measured by (18)F-fluorodeoxyglucose positron emission tomography prior to chemotherapy in estrogen receptor (ER)-positive breast cancer. We hypothesized that glu...

    The Journal of Urology 189(4):e216 (2013)

  10. Proline-Catalyzed Asymmetric Diels-Alder Reactions of ano-Quinodimethane

    Tetrahedron Letters 55(30) (2013)

    Graphical abstract
  11. Optical imaging of tumor vascularity associated with proliferation and glucose metabolism in early breast cancer: clinical application of total hemoglobin measurements in the breast.

    BMC Cancer 13:514 (2013) PMID 24176197 PMCID PMC3817816

    Near-infrared optical imaging targeting the intrinsic contrast of tissue hemoglobin has emerged as a promising approach for visualization of vascularity in cancer research. We evaluated the usefulness of diffuse optical spectroscopy using time-resolved spectroscopic (TRS) measurements for functi...
  12. Pulmonary tumor thrombotic microangiopathy showing aggressive course after transurethral resection of urinary bladder: an autopsy case report.

    Medical Molecular Morphology 45(4):238 (2012) PMID 23224604

    A 77-year-old man developed pulmonary tumor thrombotic microangiopathy (PTTM) 2 days after undergoing transurethral resection for urothelial carcinoma (G3) of the urinary bladder and died of respiratory failure 6 days later. Histological findings demonstrated marked intimal fibrocellular prolife...
  13. TCT-253 Patient and lesion characteristics of peripheral artery disease concomitant with coronary artery disease: Insights from Virtual histology intravascular ultrasound analysis

    Journal of the American College of Cardiology 60(17):B72 (2012)

  14. Axillary ultrasound examination is useful for selecting patients optimally suited for sentinel lymph node biopsy after primary systemic chemotherapy.

    The American Journal of Surgery 204(4):487 (2012) PMID 22483167

    Controversy surrounds the reliability of sentinel lymph node biopsy after primary systemic chemotherapy. In this study, we assessed axillary ultrasound for selecting patients most likely to optimally benefit from biopsy. The study included 87 patients who received primary systemic chemotherapy a...
  15. Stromal Cell-Derived Factor 1α Induces Accumulation of Intraveneously Administered Marrow-Derived Stromal Cells in the Partially Obstructed Rat Bladder.

    Luts 4(3):154 (2012) PMID 26676624

    We investigated the time course of the stromal cell-derived factor 1α (SDF1α) expression and behavior of intravenously administered bone marrow-derived stromal (BMS) cells in the urinary bladder of partial bladder outlet obstruction (PBOO) rats. Study 1: Recombinant SDF1α or saline was directly ...
  16. Quantitative prediction of tumor response to neoadjuvant chemotherapy in breast cancer: novel marker genes and prediction model using the expression levels.

    Breast Cancer 19(1):37 (2012) PMID 21437666

    In breast cancer, the identification of accurate predictors of tumor response to neoadjuvant chemotherapy is of key importance, but none of the critical markers have been validated to date. We attempted to identify potent marker genes genome-wide, and we developed a prediction model for individu...
  17. A false positive for metastatic lymph nodes in the axillary region of a breast cancer patient following mastectomy.

    Breast Cancer 18(2):141 (2011) PMID 19554397

    Recent advanced imaging modalities such as positron emission tomography (PET) detect malignancies using 2-[18F]-fluoro-2-deoxy-D: -glucose (18-FDG) with high accuracy, and they contribute to decisions regarding diagnosis, staging, recurrence, and treatment response. Here, we report a case of fal...
  18. Simultaneous activation of salicylate production and fungal resistance in transgenic Chrysanthemum producing caffeine.

    Plant Signaling & Behavior 6(3):409 (2011) PMID 21346420 PMCID PMC3142424

    Caffeine functions in the chemical defense against biotic attackers in a few plant species, including coffee and tea. Transgenic tobacco plants that endogenously produced caffeine by expressing three N-methyltransferases involved in the caffeine biosynthesis pathway exhibited a strong resistance...

    The Journal of Urology 185(4):e173 (2011)

  20. BiClamp forceps significantly shorten the operation time for breast surgery.

    Surgery Today 40(8):706 (2010) PMID 20676852

    A novel approach was introduced for breast surgery using the BiClamp, a new bipolar thermal energy device, to avoid complications and to shorten the time required for the dissection of the axillary lymph nodes. Thirty-six patients with early breast cancer were assessed. The surgical parameters w...