1. Drosophila Sugar Receptors in Sweet Taste Perception, Olfaction, and Internal Nutrient Sensing

    Current Biology 25(5):621 (2015) PMID 25702577

    Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, c...
  2. Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing.

    Current Biology 25(5):621 (2015) PMID 25702577

    Identification of nutritious compounds is dependent on expression of specific taste receptors in appropriate taste-cell types [1]. In contrast to mammals, which rely on a single, broadly tuned heterodimeric sugar receptor [2], the Drosophila genome harbors a small subfamily of eight, closely rel...
  3. A genetic tool kit for cellular and behavioral analyses of insect sugar receptors.

    Fly 8(4):189 (2014) PMID 25984594

    Arthropods employ a large family of up to 100 putative taste or gustatory receptors (Grs) for the recognition of a wide range of non-volatile chemicals. In Drosophila melanogaster, a small subfamily of 8 Gr genes is thought to mediate the detection of sugars, the fly's major nutritional source. ...
  4. An expression system for Gustatory receptors-and why it failed.

    Fly 8(4):232 (2014) PMID 25975755

    A recent paper by the Dahankuar laboratory suggested that single Drosophila sugar receptors proteins accurately mediate sugar detection when ectopically expressed in olfactory neurons of the antenna. These findings contra-dict numerous previously published electrophysiological and behavioral inv...
  5. Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

    Current Biology 24(17):1969 (2014) PMID 25131671

    Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and on taste behavior of desirable,...
  6. Enhancing Perception of Contaminated Food through Acid-Mediated Modulation of Taste Neuron Responses

    Current Biology 24(17):2071 (2014)

  7. Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

    Current Biology 24(17):1969 (2014) PMID 25131671

    Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and on taste behavior of desirable,...
  8. Enhancing Perception of Contaminated Food through Acid-Mediated Modulation of Taste Neuron Responses

    Current Biology 24(17):2071 (2014)

  9. Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

    Current Biology 24(17):1969 (2014) PMID 25131671

    Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and on taste behavior of desirable,...
  10. Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

    Current Biology 24(17):1969 (2014) PMID 25131671 PMCID PMC4332783

    Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and on taste behavior of desirable,...
  11. Enhancing Perception of Contaminated Food through Acid-Mediated Modulation of Taste Neuron Responses

    Current Biology 24(17):1969 (2014)

    Background Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions.
  12. Enhancing perception of contaminated food through acid-mediated modulation of taste neuron responses.

    Current Biology 24(17):1969 (2014) PMID 25131671 PMCID PMC4332783

    Natural foods contain not only nutrients, but also nonnutritious and potentially harmful chemicals. Thus, animals need to evaluate food content in order to make adequate feeding decisions. Here, we investigate the effects of acids on the taste neuron responses and on taste behavior of desirable,...
  13. Diverse roles for the Drosophila fructose sensor Gr43a.

    Fly 8(1):19 (2014) PMID 24406333 PMCID PMC3974889

    The detection of nutrients, both in food and within the body, is crucial for the regulation of feeding behavior, growth, and metabolism. While the molecular basis for sensing food chemicals by the taste system has been firmly linked to specific taste receptors, relatively little is known about t...
  14. Diverse roles for the Drosophila fructose sensor Gr43a.

    Fly 8(1):19 (2014) PMID 24406333 PMCID PMC3974889

    The detection of nutrients, both in food and within the body, is crucial for the regulation of feeding behavior, growth, and metabolism. While the molecular basis for sensing food chemicals by the taste system has been firmly linked to specific taste receptors, relatively little is known about t...
  15. The molecular basis of sugar sensing in Drosophila larvae.

    Current Biology 23(15):1466 (2013) PMID 23850280 PMCID PMC4294765

    Evaluation of food chemicals is essential to make appropriate feeding decisions. The molecular genetic analysis of Gustatory receptor (Gr) genes and the characterization of the neural circuits that they engage has led to a broad understanding of taste perception in adult Drosophila [1, 2]. For e...
  16. The molecular basis of sugar sensing in Drosophila larvae.

    Current Biology 23(15):1466 (2013) PMID 23850280

    Evaluation of food chemicals is essential to make appropriate feeding decisions. The molecular genetic analysis of Gustatory receptor (Gr) genes and the characterization of the neural circuits that they engage has led to a broad understanding of taste perception in adult Drosophila [1, 2]. For e...
  17. The Molecular Basis of Sugar Sensing inDrosophilaLarvae

    Current Biology 23(15):1466 (2013)

    Evaluation of food chemicals is essential to make appropriate feeding decisions. The molecular genetic analysis of Gustatory receptor (Gr) genes and the characterization of the neural circuits that they engage has led to a broad understanding of taste perception in adult Drosophila [1,...
  18. The Molecular Basis of Sugar Sensing in Drosophila Larvae

    Current Biology 23(15):1466 (2013) PMID 23850280 PMCID PMC4294765

    Evaluation of food chemicals is essential to make appropriate feeding decisions. The molecular genetic analysis of Gustatory receptor (Gr) genes and the characterization of the neural circuits that they engage has led to a broad understanding of taste perception in adult Drosophila [1,...
  19. The molecular basis of sugar sensing in Drosophila larvae.

    Current Biology 23(15):1466 (2013) PMID 23850280 PMCID PMC4294765

    Evaluation of food chemicals is essential to make appropriate feeding decisions. The molecular genetic analysis of Gustatory receptor (Gr) genes and the characterization of the neural circuits that they engage has led to a broad understanding of taste perception in adult Drosophila [1, 2]. For e...
  20. Nutrient sensors

    Current Biology 23(9):R369 (2013)

    Elucidating the cellular and molecular basis of nutrient metabolism and regulation of feeding has become a major focus in scientific research over the last twenty years. Because of the increasing number of overweight and obese people in western and other societies, research efforts hav...