Synthesis of nanostructured and biofunctionalized water-in-oil droplets as tools for homing T cells.
We synthesized a new type of gold-linked surfactant and used a drop-based microfluidic device to develop and characterize novel nanostructured and specifically biofunctionalized droplets of water-in-oil emulsions as 3D APC analogues. Combining flexible biofunctionalization with the pliable physical...
Self-assembly of organic monolayers as protective and conductive bridges for nanometric surface-mount applications.
We present a novel surface-mount placement process that could potentially overcome the inadequacies of the currently used stencil-printing technology, when applied to devices in which either their lateral and/or their horizontal dimensions approach the nanometric scale. Our novel process is based on...
Engineering of synthetic cellular microenvironments: implications for immunity.
We discuss novel synthetic approaches for studying the interactions of cells with their microenvironment. Notably, critical cellular processes such as growth, differentiation, migration, and fate determination, are tightly regulated by interactions with neighboring cells, and the surrounding extrace...
Soft/elastic nanopatterned biointerfaces in the service of cell biology.
Engineering of biomimetic interfaces has become a valuable tool for guiding cellular processes such as adhesion, spreading, motility, as well as proliferation, differentiation, and apoptosis. The interaction of cells with the extracellular matrix (ECM) or with other cells is involved in nearly every...
Oxidation of Polycrystalline Copper Thin Films at Ambient Conditions
Key factors for stable retention of fluorophores and labeled biomolecules in droplet-based microfluidics.
We investigated the retention of 12 commonly used water-soluble dyes in droplets having six different aqueous phase conditions. We demonstrate that the physicochemical properties of the dyes have a major influence on the retention level. In particular, hydrophilicity has a strong influence on retent...
Formation of ultrasmooth and highly stable copper surfaces through annealing and self-assembly of organic monolayers.
We show the potential values of highly stable and ultrasmooth polycrystalline bare Cu obtained by simple annealing and chemical modification for a wide range of Cu-based electronic devices. The morphological properties and oxidation behavior of annealed Cu surfaces, before and after coating by self-...