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  1. Key factors for stable retention of fluorophores and labeled biomolecules in droplet-based microfluidics.

    Analytical chemistry 87(4):2063 (2015) PMID 25607822

    Water-in-oil emulsion droplets created in droplet-based microfluidic devices have been tested and used recently as well-defined picoliter-sized 3D compartments for various biochemical and biomedical applications. In many of these applications, fluorescence measurements are applied to reveal the ...
  2. Engineering of synthetic cellular microenvironments: Implications for immunity

    Journal of Autoimmunity 54:100 (2014) PMID 24951031

    In this article, we discuss novel synthetic approaches for studying the interactions of cells with their microenvironment. Notably, critical cellular processes such as growth, differentiation, migration, and fate determination, are tightly regulated by interactions with neighboring cel...
  3. Soft/elastic nanopatterned biointerfaces in the service of cell biology.

    Methods in Cell Biology 119:237 (2014) PMID 24439288

    Engineering of biomimetic interfaces has become a valuable tool for guiding cellular processes such as adhesion, spreading, motility, as well as proliferation, differentiation, and apoptosis. The interaction of cells with the extracellular matrix (ECM) or with other cells is involved in nearly e...
  4. Synthesis of nanostructured and biofunctionalized water-in-oil droplets as tools for homing T cells.

    Journal of the American Chemical Society 135(9):3339 (2013) PMID 23419177 PMCID PMC3806295

    Activation, ex vivo expansion of T cells, differentiation into a regulatory subset, and its phenotype-specific high-throughput selection represent major challenges in immunobiology. In part, this is due to the lack of technical means to synthesize suitable 3D extracellular systems to imitate ex ...
  5. Self-assembly of organic monolayers as protective and conductive bridges for nanometric surface-mount applications.

    ACS Applied Materials & Interfaces 2(9):2585 (2010) PMID 20804143

    In this work, we present a novel surface-mount placement process that could potentially overcome the inadequacies of the currently used stencil-printing technology, when applied to devices in which either their lateral and/or their horizontal dimensions approach the nanometric scale. Our novel p...
  6. Formation of ultrasmooth and highly stable copper surfaces through annealing and self-assembly of organic monolayers.

    Langmuir 26(1):191 (2010) PMID 19715329

    Copper (Cu) has been extensively used as an interconnect material for microelectronic devices because of its high electrical and thermal conductivity and excellent electromigration resistance. However, the formation of relatively rough Cu surfaces ( approximately 5 nm roughness) and Cu-oxide lay...