1. Cross-species proteomics reveals specific modulation of signaling in cancer and stromal cells by phosphoinositide 3-kinase (PI3K) inhibitors.

    Molecular & Cellular Proteomics 13(6):1457 (2014) PMID 24648465 PMCID PMC4047466

    The tumor microenvironment plays key roles in cancer biology, but its impact on the regulation of signaling pathway activity in cancer cells has not been systemically investigated. We designed an analytical strategy that allows differential analysis of signaling between cancer and stromal cells ...
  2. Proteomic analysis of rat plasma following transient focal cerebral ischemia.

    Biomarkers in Medicine 5(6):837 (2011) PMID 22103620

    This study aimed to identify plasma protein changes in a rat model of ischemic stroke using a proteomic approach. Four male Sprague-Dawley rats (3-6 months old) were subjected to 90 min of left middle cerebral artery occlusion under anesthesia with 1.5% isoflurane in O(2)/air followed by 24-h re...
  3. Methylmercury disrupts the balance between phosphorylated and non-phosphorylated cofilin in primary cultures of mice cerebellar granule cells. A proteomic study.

    Toxicology and Applied Pharmacology 242(1):109 (2010) PMID 19800906

    Methylmercury is an environmental contaminant that is particularly toxic to the developing central nervous system; cerebellar granule neurons are especially vulnerable. Here, primary cultures of cerebellar granule cells (CGCs) were continuously exposed to methylmercury for up to 16 days in vitro...
  4. Probucol increases glutathione peroxidase-1 activity and displays long-lasting protection against methylmercury toxicity in cerebellar granule cells.

    Toxicological Sciences 112(2):416 (2009) PMID 19770487

    Methylmercury (MeHg) is an environmental neurotoxicant whose molecular mechanisms underlying toxicity remain elusive. Here, we investigated molecular events involved in MeHg-induced neurotoxicity in cultured cerebellar granule cells (CGCs) as well as potential protective strategies for such toxi...
  5. GABA released from cultured cortical neurons influences the modulation of t-[(35)S]butylbicyclophosphorothionate binding at the GABAA receptor Effects of thymol.

    European Journal of Pharmacology 600(1-3):26 (2008) PMID 18938153

    Thymol is a monoterpene that specifically interacts with synaptic neural functions in neuronal GABA-operated Cl(-) channels. Here we explore the effects of thymol, and propofol as positive control, on t-[(35)S]butylbicyclophosphorothionate ([(35)S]TBPS) binding in primary cultures of cortical ne...
  6. Oxidative stress in cerebellar granule neurons exposed to methylmercury and manganese

    Toxicology Letters 180:S41 (2008)

  7. Cell viability and proteomic analysis in cultured neurons exposed to methylmercury.

    Human & Experimental Toxicology 26(4):263 (2007) PMID 17615107

    Methylmercury is an environmental contaminant with special selectivity for cerebellar granule cells. The aim of this study was to determine the effect of long-term methylmercury exposure on cell viability and cellular proteome in cultured cerebellar granule cells. Primary cultures of mice cerebe...