1. Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers.

    Gene 576(1 Pt 3):483 (2016) PMID 26519551

    The methylation of promoter CpG islands and interactions between microRNAs (miRNAs) and messenger RNAs (mRNAs) of target genes are considered two crucial epigenetic mechanisms for inducing gene and pathway deregulation in tumors. Here, the expression levels of seven cancer-associated 3p genes (R...
  2. Tumor Suppressor Function of the SEMA3B Gene in Human Lung and Renal Cancers.

    PLoS ONE 10(5):e0123369 (2015) PMID 25961819 PMCID PMC4427300

    The SEMA3B gene is located in the 3p21.3 LUCA region, which is frequently affected in different types of cancer. The objective of our study was to expand our knowledge of the SEMA3B gene as a tumor suppressor and the mechanisms of its inactivation. In this study, several experimental approaches ...
  3. LRRC3B gene is frequently epigenetically inactivated in several epithelial malignancies and inhibits cell growth and replication.

    Biochimie 94(5):1151 (2012) PMID 22321817

    Chromosome 3 specific NotI microarrays containing 180 NotI linking clones associated with 188 genes were hybridized to NotI representation probes prepared using matched tumor/normal samples from major epithelial cancers: breast (47 pairs), lung (40 pairs) cervical (43 pairs), kidney (34 pairs of...
  4. Genetic and epigenetic analysis of non-small cell lung cancer with NotI-microarrays.

    Epigenetics 7(5):502 (2012) PMID 22491060

    This study aimed to clarify genetic and epigenetic alterations that occur during lung carcinogenesis and to design perspective sets of newly identified biomarkers. The original method includes chromosome 3 specific NotI-microarrays containing 180 NotI clones associated with genes for hybridizati...
  5. Differential expression of CHL1 gene during development of major human cancers.

    PLoS ONE 6(3):e15612 (2011) PMID 21408220 PMCID PMC3049765

    CHL1 gene (also known as CALL) on 3p26.3 encodes a one-pass trans-membrane cell adhesion molecule (CAM). Previously CAMs of this type, including L1, were shown to be involved in cancer growth and metastasis. We used Clontech Cancer Profiling Arrays (19 different types of cancers, 395 samples) to...