1. Endotoxaemic myocardial dysfunction: the role of coronary driving pressure in subendocardial perfusion.

    Critical care and resuscitation : journal of th... 17(1):12 (2015) PMID 25702757

    To investigate the role of coronary driving pressure (CDP) in myocardial microcirculatory blood flow during sepsis. We hypothesised that in septic shock there is an impaired autoregulation of microcirculation, and blood flow is totally dependent on CDP. We analysed the effect of lipopolysacchari...
  2. Endotoxaemic myocardial dysfunction: the role of coronary driving pressure in subendocardial perfusion.

    Critical care and resuscitation : journal of th... 17(1):12 (2015) PMID 25702757

    To investigate the role of coronary driving pressure (CDP) in myocardial microcirculatory blood flow during sepsis. We hypothesised that in septic shock there is an impaired autoregulation of microcirculation, and blood flow is totally dependent on CDP. We analysed the effect of lipopolysacchari...
  3. Endotoxaemic myocardial dysfunction: the role of coronary driving pressure in subendocardial perfusion.

    Critical care and resuscitation : journal of th... 17(1):12 (2015) PMID 25702757

    To investigate the role of coronary driving pressure (CDP) in myocardial microcirculatory blood flow during sepsis. We hypothesised that in septic shock there is an impaired autoregulation of microcirculation, and blood flow is totally dependent on CDP. We analysed the effect of lipopolysacchari...
  4. Hypertonic saline solution for prevention of renal dysfunction in patients with decompensated heart failure

    International Journal of Cardiology 167(1):34 (2013)

    Background Renal dysfunction is associated with increased mortality in patients with decompensated heart failure. However, interventions targeted to prevention in this setting have been disappointing. We investigated the effects of hypertonic saline solution (HSS) for prevent...
  5. Hypertonic saline solution for prevention of renal dysfunction in patients with decompensated heart failure.

    International Journal of Cardiology 167(1):34 (2013) PMID 22243938

    Renal dysfunction is associated with increased mortality in patients with decompensated heart failure. However, interventions targeted to prevention in this setting have been disappointing. We investigated the effects of hypertonic saline solution (HSS) for prevention of renal dysfunction in dec...
  6. Inducible nitric oxide synthase inhibition increases MMP-2 activity leading to imbalance between extracellular matrix deposition and degradation after polypropylene mesh implant.

    Journal of Biomedical Materials Research, Part A 101(5):1379 (2013) PMID 23077110

    Prosthetic mesh implants are commonly used to correct abdominal wall defects. However, success of the procedure is conditioned by an adequate inflammatory response to the device. We hypothesized that nitric oxide produced by nitric oxide synthase 2 (NOS2) and MMP-2 and -9 participate in response...
  7. Inducible nitric oxide synthase inhibition increases MMP-2 activity leading to imbalance between extracellular matrix deposition and degradation after polypropylene mesh implant.

    Journal of Biomedical Materials Research, Part A 101(5):1379 (2013) PMID 23077110

    Prosthetic mesh implants are commonly used to correct abdominal wall defects. However, success of the procedure is conditioned by an adequate inflammatory response to the device. We hypothesized that nitric oxide produced by nitric oxide synthase 2 (NOS2) and MMP-2 and -9 participate in response...
  8. Effects of terlipressin and naloxone compared with epinephrine in a rat model of asphyxia-induced cardiac arrest.

    Clinics 68(8):1146 (2013) PMID 24037012 PMCID PMC3752630

    To evaluate the hemodynamic and metabolic effects of terlipressin and naloxone in cardiac arrest. Cardiac arrest in rats was induced by asphyxia and maintained for 3.5 minutes. Animals were then resuscitated and randomized into one of six groups: placebo (n = 7), epinephrine (0.02 mg/kg; n = 7),...
  9. Dyslipidemia: a prospective controlled randomized trial of intensive glycemic control in sepsis.

    Intensive Care Medicine 38(4):634 (2012) PMID 22297666

    Metabolic disturbances are quite common in critically ill patients. Glycemic control appears to be an important adjuvant therapy in such patients. In addition, disorders of lipid metabolism are associated with worse prognoses. The purpose of this study was to investigate the effects that two dif...
  10. Dyslipidemia: a prospective controlled randomized trial of intensive glycemic control in sepsis.

    Intensive Care Medicine 38(4):634 (2012) PMID 22297666

    Metabolic disturbances are quite common in critically ill patients. Glycemic control appears to be an important adjuvant therapy in such patients. In addition, disorders of lipid metabolism are associated with worse prognoses. The purpose of this study was to investigate the effects that two dif...
  11. Nitric oxide modulates metalloproteinase-2, collagen deposition and adhesion rate after polypropylene mesh implantation in the intra-abdominal wall.

    Acta Biomaterialia 8(1):108 (2012) PMID 21864729

    Prosthetic meshes are commonly used to correct abdominal wall defects. However, the inflammatory reaction induced by these devices in the peritoneum is not completely understood. We hypothesized that nitric oxide (NO), produced by nitric oxide synthase 2 (NOS2) may modulate the response induced ...
  12. Nitric oxide modulates metalloproteinase-2, collagen deposition and adhesion rate after polypropylene mesh implantation in the intra-abdominal wall.

    Acta Biomaterialia 8(1):108 (2012) PMID 21864729

    Prosthetic meshes are commonly used to correct abdominal wall defects. However, the inflammatory reaction induced by these devices in the peritoneum is not completely understood. We hypothesized that nitric oxide (NO), produced by nitric oxide synthase 2 (NOS2) may modulate the response induced ...
  13. Nitric oxide modulates metalloproteinase-2, collagen deposition and adhesion rate after polypropylene mesh implantation in the intra-abdominal wall

    Acta Biomaterialia 8(1):108 (2012)

    Prosthetic meshes are commonly used to correct abdominal wall defects. However, the inflammatory reaction induced by these devices in the peritoneum is not completely understood. We hypothesized that nitric oxide (NO), produced by nitric oxide synthase 2 (NOS2) may modulate the respons...
  14. Effect of laser phototherapy on wound healing following cerebral ischemia by cryogenic injury.

    Journal of Photochemistry and Photobiology B: B... 105(3):207 (2011) PMID 22024356

    Laser phototherapy emerges as an alternative or auxiliary therapy for acute ischemic stroke, traumatic brain injury, degenerative brain disease, spinal cord injury, and peripheral nerve regeneration, but its effects are still controversial. We have previously found that laser phototherapy immuno...
  15. Effect of laser phototherapy on wound healing following cerebral ischemia by cryogenic injury

    Journal of Photochemistry and Photobiology B: B... 105(3):207 (2011)

    Highlights ► The most striking findings were: lased lesions showed smaller tissue loss than control lesions in 6 h. ► During the first 24 h the amount of viable neurons was significantly higher in the lased group. ► There was a remarkable increase in the amount of GFAP in t...
  16. Gene expression reprogramming protects macrophage from septic-induced cell death.

    Molecular Immunology 47(16):2587 (2010) PMID 20728938

    Sepsis induces a systemic inflammatory response leading to tissue damage and cell death. LPS tolerance affects inflammatory response. To comprehend potential new mechanisms of immune regulation in endotoxemia, we examined macrophage mRNA expression by macroarray affected by LPS tolerance. LPS to...
  17. Loss of CD40 endogenous S-nitrosylation during inflammatory response in endotoxemic mice and patients with sepsis.

    Shock 33(6):626 (2010) PMID 20473113

    Signal transduction through the surface molecule CD40 is critical for cellular activation in immunoinflammatory states such as sepsis. The mechanisms regulating this pathway are not completely understood. Because CD40 displays potentially regulatory cysteine residues and CD40 is probably exposed...
  18. Endotoxin tolerance: selective alterations in gene expression and protection against lymphocyte death.

    Immunobiology 215(6):435 (2010) PMID 19800145

    Extensive lymphocyte apoptosis may be an important cause of immune suppression in sepsis. Here we investigated the effect of LPS tolerance on lymphocyte apoptosis in an experimental model of polymicrobial infection. Tolerance was induced by the injection of lipopolysaccharide (1.0mg/kg/subcutane...
  19. Endotoxin tolerance: selective alterations in gene expression and protection against lymphocyte death.

    Immunobiology 215(6):435 (2010) PMID 19800145

    Extensive lymphocyte apoptosis may be an important cause of immune suppression in sepsis. Here we investigated the effect of LPS tolerance on lymphocyte apoptosis in an experimental model of polymicrobial infection. Tolerance was induced by the injection of lipopolysaccharide (1.0mg/kg/subcutane...
  20. Loss of CD40 endogenous S-nitrosylation during inflammatory response in endotoxemic mice and patients with sepsis.

    Shock 33(6):626 (2010) PMID 20473113

    Signal transduction through the surface molecule CD40 is critical for cellular activation in immunoinflammatory states such as sepsis. The mechanisms regulating this pathway are not completely understood. Because CD40 displays potentially regulatory cysteine residues and CD40 is probably exposed...