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  1. A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity.

    Circulation 127(1):74 (2013) PMID 23186644

    We examine the cardiac effects of the glucagon-like peptide-1 analog liraglutide in a model of obesity, independent of changes in body weight. C57Bl6 mice were placed on a 45% high-fat diet (HFD) or a regular chow diet. Mice on HFD developed 46±2% and 60±2% greater body weight relative to regular ch...
  2. Phosphatidylethanolamine synthesized by three different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae

    Chemistry and Physics of Lipids 149:S53 (2007)

  3. Diverse roles for the p24 family of proteins in eukaryotic cells.

    BioMolecular Concepts 3(6):561 (2012) PMID 25436559

    I transmembrane proteins that are abundant components of the early secretory pathway. Topologically, the proteins have a large luminal domain and a short cytoplasmic domain that allows for targeting to both coat protein complex II and coat protein complex I vesicles, and thus these proteins cycle be...
  4. SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells.

    Journal of Cell Science 126(Pt 9):1962 (2013) PMID 23444373

    We show that SDF2L1 protein levels are increased in response to ER stress-inducing compounds, but not other cell stressors that we tested in insulinoma cell lines. SDF2L1 protein levels were also induced by expression of misfolded proinsulin in insulinoma cells and in islets from diabetic mice. Immu...
  5. Phosphatidylethanolamine synthesized by four different pathways is supplied to the plasma membrane of the yeast Saccharomyces cerevisiae.

    Biochimica et Biophysica Acta 1801(4):480 (2010) PMID 20044027

    We examined the contribution of the four different pathways of phosphatidylethanolamine (PE) synthesis in the yeast Saccharomyces cerevisiae to the supply of this phospholipid to the plasma membrane. These pathways of PE formation are decarboxylation of phosphatidylserine (PS) by (i) phosphatidylser...
  6. Phosphatidylserine decarboxylases, key enzymes of lipid metabolism.

    Iubmb Life 61(2):151 (2009) PMID 19165886

    I PSDs include enzymes of eukaryotic mitochondria and bacterial origin which contain the amino acid sequence LGST as a characteristic motif. Type II PSDs are found in the endomembrane system of eukaryotes and contain a typical GGST motif. These characteristic motifs are considered as autocatalytic c...
  7. A yeast mutant deleted ofGPH1bears defects in phospholipid metabolism

    Chemistry and Physics of Lipids 164:S45 (2011)

  8. Action of protein disulfide isomerase on proinsulin exit from endoplasmic reticulum of pancreatic β-cells.

    Journal of Biological Chemistry 287(1):43 (2012) PMID 22105075 PMCID PMC3249095

    We have examined the effect of PDI knockdown (PDI-KD) in β-cells. The data establish that upon PDI-KD, oxidation of proinsulin to form native disulfide bonds is unimpaired and in fact enhanced. This is accompanied by improved proinsulin exit from the ER and increased total insulin secretion, with no...
  9. Transcriptional response to deletion of the phosphatidylserine decarboxylase Psd1p in the yeast Saccharomyces cerevisiae.

    PLoS ONE 8(10):e77380 (2013) PMID 24146988 PMCID PMC3795641

    We performed a DNA microarray analysis with a ∆psd1 deletion mutant. This approach revealed that 54 yeast genes were significantly up-regulated in the absence of PSD1 compared to wild type. Surprisingly, marked down-regulation of genes was not observed. A number of different cellular processes in di...
  10. Endoplasmic reticulum redox state is not perturbed by pharmacological or pathological endoplasmic reticulum stress in live pancreatic β-cell...

    PLoS ONE 7(11):e48626 (2012) PMID 23144914 PMCID PMC3493583

    We monitored ER redox together with transcriptional output of the Unfolded Protein Response (UPR) in INS-1 insulinoma cells stably expressing eroGFP (ER-redox-sensor) and mCherry protein driven by a GRP78 promoter (UPR-sensor). Live cell imaging, flow cytometry and biochemical characterization were...