1. Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo.

    Cancer Cell 27(4):473 (2015) PMID 25873171

    Therapeutic antibodies have transformed cancer therapy, unlocking mechanisms of action by engaging the immune system. Unfortunately, cures rarely occur and patients display intrinsic or acquired resistance. Here, we demonstrate the therapeutic potential of targeting human (h) FcγRIIB (CD32B), a ...
  2. Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair.

    PLoS Pathogens 11(3):e1004778 (2015) PMID 25806513 PMCID PMC4373753

    Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses targeted against these tissue-disruptiv...
  3. Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I.

    Journal of Immunology 194(3):1154 (2015) PMID 25548226 PMCID PMC4298127

    Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helminth larvae, which ideally should be mimic...
  4. Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fcγ Receptor I.

    Journal of Immunology 194(3):1154 (2015) PMID 25548226

    Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helminth larvae, which ideally should be mimic...
  5. Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fcγ Receptor I.

    Journal of Immunology 194(3):1154 (2015) PMID 25548226 PMCID PMC4298127

    Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helminth larvae, which ideally should be mimic...
  6. Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fcγ Receptor I.

    Journal of Immunology 194(3):1154 (2015) PMID 25548226 PMCID PMC4298127

    Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helminth larvae, which ideally should be mimic...
  7. Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fcγ Receptor I.

    Journal of Immunology 194(3):1154 (2015) PMID 25548226 PMCID PMC4298127

    Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helminth larvae, which ideally should be mimic...
  8. Conformation of the human immunoglobulin g2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.

    Cancer Cell 27(1):138 (2015) PMID 25500122 PMCID PMC4297290

    Monoclonal antibody (mAb) drugs that stimulate antitumor immunity are transforming cancer treatment but require optimization for maximum clinical impact. Here, we show that, unlike other immunoglobulin isotypes, human IgG2 (h2) imparts FcγR-independent agonistic activity to immune-stimulatory mA...
  9. Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.

    Cancer Cell 27(1):138 (2015) PMID 25500122 PMCID PMC4297290

    Monoclonal antibody (mAb) drugs that stimulate antitumor immunity are transforming cancer treatment but require optimization for maximum clinical impact. Here, we show that, unlike other immunoglobulin isotypes, human IgG2 (h2) imparts FcγR-independent agonistic activity to immune-stimulatory mA...
  10. Conformation of the human immunoglobulin g2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies.

    Cancer Cell 27(1):138 (2015) PMID 25500122

    Monoclonal antibody (mAb) drugs that stimulate antitumor immunity are transforming cancer treatment but require optimization for maximum clinical impact. Here, we show that, unlike other immunoglobulin isotypes, human IgG2 (h2) imparts FcγR-independent agonistic activity to immune-stimulatory mA...
  11. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.

    Arthritis research & therapy 17(1):6 (2015) PMID 25596646 PMCID PMC4325944

    CD55, a glycosylphosphatidylinositol-anchored, complement-regulating protein (decay-accelerating factor), is expressed by fibroblast-like synoviocytes (FLS) with high local abundance in the intimal lining layer. We here explored the basis and consequences of this uncommon presence. Synovial tiss...
  12. The Long Pentraxin PTX3 Promotes Fibrocyte Differentiation.

    PLoS ONE 10(3):e0119709 (2015) PMID 25774777 PMCID PMC4361553

    Monocyte-derived, fibroblast-like cells called fibrocytes are associated with fibrotic lesions. The plasma protein serum amyloid P component (SAP; also known as pentraxin-2, PTX2) inhibits fibrocyte differentiation in vitro, and injections of SAP inhibit fibrosis in vivo. SAP is a member of the ...
  13. FcRγ-Chain ITAM Signaling Is Critically Required for Cross-Presentation of Soluble Antibody-Antigen Complexes by Dendritic Cells.

    Journal of Immunology 193(11):5506 (2014) PMID 25355925

    The uptake of Ag-Ab immune complexes (IC) after the ligation of activating FcγR on dendritic cells (DC) leads to 100 times more efficient Ag presentation than the uptake of free Ags. FcγRs were reported to facilitate IC uptake and simultaneously induce cellular activation that drives DC maturati...
  14. FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells.

    Journal of Immunology 193(11):5506 (2014) PMID 25355925

    The uptake of Ag-Ab immune complexes (IC) after the ligation of activating FcγR on dendritic cells (DC) leads to 100 times more efficient Ag presentation than the uptake of free Ags. FcγRs were reported to facilitate IC uptake and simultaneously induce cellular activation that drives DC maturati...
  15. FcRγ-chain ITAM signaling is critically required for cross-presentation of soluble antibody-antigen complexes by dendritic cells.

    Journal of Immunology 193(11):5506 (2014) PMID 25355925

    The uptake of Ag-Ab immune complexes (IC) after the ligation of activating FcγR on dendritic cells (DC) leads to 100 times more efficient Ag presentation than the uptake of free Ags. FcγRs were reported to facilitate IC uptake and simultaneously induce cellular activation that drives DC maturati...
  16. Fcγ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization.

    Journal of Immunology 193(4):1828 (2014) PMID 25024386

    Immunomodulatory mAbs, led by the anti-CTLA4 mAb ipilimumab, are an exciting new class of drugs capable of promoting anticancer immunity and providing durable control of some tumors. Close analysis of a number of agents has revealed a critical yet variable role for Fcγ receptors in their efficac...
  17. Fcγ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization.

    Journal of Immunology 193(4):1828 (2014) PMID 25024386

    Immunomodulatory mAbs, led by the anti-CTLA4 mAb ipilimumab, are an exciting new class of drugs capable of promoting anticancer immunity and providing durable control of some tumors. Close analysis of a number of agents has revealed a critical yet variable role for Fcγ receptors in their efficac...
  18. Fcγ receptor dependency of agonistic CD40 antibody in lymphoma therapy can be overcome through antibody multimerization.

    Journal of Immunology 193(4):1828 (2014) PMID 25024386

    Immunomodulatory mAbs, led by the anti-CTLA4 mAb ipilimumab, are an exciting new class of drugs capable of promoting anticancer immunity and providing durable control of some tumors. Close analysis of a number of agents has revealed a critical yet variable role for Fcγ receptors in their efficac...
  19. Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI.

    Journal of Leukocyte Biology 96(2):275 (2014) PMID 24752483 PMCID PMC4101091

    Monocyte-derived, fibroblast-like cells, called fibrocytes, participate in wound-healing and the formation of fibrotic lesions. Aggregated or cross-linked IgG are key effectors in infections, autoimmune diseases, anaphylaxis, and immunotherapy. Cells, including monocytes and fibrocytes, bind IgG...
  20. Inhibition of murine fibrocyte differentiation by cross-linked IgG is dependent on FcγRI.

    Journal of Leukocyte Biology 96(2):275 (2014) PMID 24752483 PMCID PMC4101091

    Monocyte-derived, fibroblast-like cells, called fibrocytes, participate in wound-healing and the formation of fibrotic lesions. Aggregated or cross-linked IgG are key effectors in infections, autoimmune diseases, anaphylaxis, and immunotherapy. Cells, including monocytes and fibrocytes, bind IgG...