1. Dissolution dynamic nuclear polarization of non-self-glassing agents: spectroscopy and relaxation of hyperpolarized [1-(13)c]acetate.

    Journal of Physical Chemistry A: Molecules, Spe... 119(10):1885 (2015) PMID 25686013

    The intrinsic physicochemical properties of the sample formulation are the key factors for efficient hyperpolarization through dissolution dynamic nuclear polarization (dissolution-DNP). We provide a comprehensive characterization of the DNP process for Na-[1-(13)C]acetate selected as a model fo...
  2. Insufficient insulin administration to diabetic rats increases substrate utilization and maintains lactate production in the kidney.

    Physiological Reports 2(12) (2014) PMID 25501426

    Good glycemic control is crucial to prevent the onset and progression of late diabetic complications, but insulin treatment often fails to achieve normalization of glycemic control to the level seen in healthy controls. In fact, recent experimental studies indicate that insufficient treatment wi...
  3. Simultaneous multiagent hyperpolarized (13) C perfusion imaging.

    Magnetic Resonance in Medicine 72(6):1599 (2014) PMID 24382698 PMCID PMC4077988

    To demonstrate simultaneous hyperpolarization and imaging of three (13) C-labeled perfusion MRI contrast agents with dissimilar molecular structures ([(13) C]urea, [(13) C]hydroxymethyl cyclopropane, and [(13) C]t-butanol) and correspondingly variable chemical shifts and physiological characteri...
  4. Simultaneous multiagent hyperpolarized (13)C perfusion imaging.

    Magnetic Resonance in Medicine 72(6):1599 (2014) PMID 24382698 PMCID PMC4077988

    To demonstrate simultaneous hyperpolarization and imaging of three (13)C-labeled perfusion MRI contrast agents with dissimilar molecular structures ([(13)C]urea, [(13)C]hydroxymethyl cyclopropane, and [(13)C]t-butanol) and correspondingly variable chemical shifts and physiological characteristic...
  5. In vivo measurement of apparent diffusion coefficients of hyperpolarized ¹³C-labeled metabolites.

    NMR in Biomedicine 27(5):561 (2014) PMID 24664927

    The combination of hyperpolarized MRS with diffusion weighting (dw) allows for determination of the apparent diffusion coefficient (ADC), which is indicative of the intra- or extracellular localization of the metabolite. Here, a slice-selective pulsed-gradient spin echo sequence was implemented ...
  6. Enhanced performance large volume dissolution-DNP.

    PMID 24531395

    A systematic study of the performance of the dissolution process in dissolution-DNP is presented. A relatively simple set of modifications is made to the standard Hypersense dissolution system to enable polarization of large volume samples. These consist of a large volume sample cup along with s...
  7. In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding.

    PMID 24486720

    Hyperpolarized metabolic imaging is a growing field that has provided a new tool for analyzing metabolism, particularly in cancer. Given the short life times of the hyperpolarized signal, fast and effective spectroscopic imaging methods compatible with dynamic metabolic characterizations are nec...
  8. Enhanced performance large volume dissolution-DNP

    Journal of Magnetic Resonance 240:90 (2014)

  9. In vivosingle-shot13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

    Journal of Magnetic Resonance 240:8 (2014)

    Graphical abstract
  10. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  11. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  12. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  13. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  14. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  15. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  16. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  17. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  18. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  19. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

    NMR in Biomedicine 26(12):1696 (2013) PMID 23946252 PMCID PMC4238807

    Hyperpolarized NMR is a promising technique for non-invasive imaging of tissue metabolism in vivo. However, the pathways that can be studied are limited by the fast T1 decay of the nuclear spin order. In metabolites containing pairs of coupled nuclear spins-1/2, the spin order may be maintained ...
  20. Formulation and utilization of choline based samples for dissolution dynamic nuclear polarization

    Journal of Magnetic Resonance 236:26 (2013)