"Are You Sure?": Lapses in Self-Reported Activities Among Healthy Older Adults Reporting Online.
Journal of Applied Gerontology 35(6):627 (2016)
Accurate retrospective reporting of activities and symptoms has been shown to be problematic for older adults, yet standard clinical care relies on self-reports to aid in assessment and management. Our aim was to examine the relationship between self-report and sensor-based measures of activity....
Surgery is associated with ventricular enlargement as well as cognitive and functional decline.
Alzheimer's & Dementia 12(5):590 (2016)
In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ε4 (APOE ε4), and AD remains unclear.
We performed a retrospective cohort analy...
Less Daily Computer Use is Related to Smaller Hippocampal Volumes in Cognitively Intact Elderly.
Journal of Alzheimer's Disease 52(2):713 (2016)
Computer use is becoming a common activity in the daily life of older individuals and declines over time in those with mild cognitive impairment (MCI). The relationship between daily computer use (DCU) and imaging markers of neurodegeneration is unknown.
The objective of this study was to examin...
Embedded Online Questionnaire Measures Are Sensitive to Identifying Mild Cognitive Impairment.
Alzheimer Disease and Associated Disorders 30(2):152 (2016)
Early changes in cognitively demanding daily activities occur between normal cognition and the development of mild cognitive impairment (MCI). These real-world functional changes as early signals of cognitive change form a prime target for meaningful early detection of dementia. We examined whet...
Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer's disease subjects.
Acta Neuropsychiatrica 27(5):270 (2015)
We undertook a non-targeted lipidomics analysis of post-mortem cerebrospinal fluid (CSF), frontal cortex grey matter, and subjacent white matter to define potential biomarkers that distinguish cognitively intact subjects from those with incipient or established dementia. Our objective was to inc...
Ubiquitous Real-World Sensing and Audiology-Based Health Informatics.
Journal of the American Academy of Audiology 26(9):777 (2015)
Hearing impairment and hearing rehabilitation strategies have historically been studied within the confines of a sound booth under controlled experimental conditions. The real world is quite different from the clinical setting and it is important to study how a person with hearing impairment int...
Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
JAMA Neurology 72(2):209 (2015)
Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this varia...
Pervasive Computing Technologies to Continuously Assess Alzheimer's Disease Progression and Intervention Efficacy.
Frontiers in Aging Neuroscience 7:102 (2015)
Traditionally, assessment of functional and cognitive status of individuals with dementia occurs in brief clinic visits during which time clinicians extract a snapshot of recent changes in individuals' health. Conventionally, this is done using various clinical assessment tools applied at the po...
Use of High-Frequency In-Home Monitoring Data May Reduce Sample Sizes Needed in Clinical Trials.
PLoS ONE 10(9):e0138095 (2015)
Trials in Alzheimer's disease are increasingly focusing on prevention in asymptomatic individuals. This poses a challenge in examining treatment effects since currently available approaches are often unable to detect cognitive and functional changes among asymptomatic individuals. Resultant smal...
Social Markers of Mild Cognitive Impairment: Proportion of Word Counts in Free Conversational Speech.
Current Alzheimer Research 12(6):513 (2015)
Detecting early signs of Alzheimer's disease (AD) and mild cognitive impairment (MCI) during the pre-symptomatic phase is becoming increasingly important for costeffective clinical trials and also for deriving maximum benefit from currently available treatment strategies. However, distinguishing...
Corrigendum: Pervasive computing technologies to continuously assess Alzheimer's disease progression and intervention efficacy.
Frontiers in Aging Neuroscience 7:232 (2015)
[This corrects the article on p. 102 in vol. 7, PMID: 26113819.].
Targeted Lipidomics of Fontal Cortex and Plasma Diacylglycerols (DAG) in Mild Cognitive Impairment and Alzheimer's Disease: Validation of DAG Accumulation Early in the Pathophysiology of Alzheimer's Disease.
Journal of Alzheimer's Disease 48(2):537 (2015)
Previous studies have demonstrated augmented levels of diacylglycerols (DAG) in the frontal cortex and plasma of Alzheimer's disease (AD) patients. We extended these findings from non-targeted lipidomics studies to design a lipidomics platform to interrogate DAGs and monoacylglycerols (MAG) in t...
Biomarker progressions explain higher variability in stage-specific cognitive decline than baseline values in Alzheimer disease.
Alzheimer's & Dementia 10(6):690 (2014)
It is unknown which commonly used Alzheimer disease (AD) biomarker values-baseline or progression-best predict longitudinal cognitive decline.
526 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI). ADNI composite memory and executive scores were the primary outcomes. Individua...
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
JAMA Neurology 71(11):1394 (2014)
Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants.
To investigate the effects of known Alzheimer disease risk lo...
Unobtrusive in-home detection of time spent out-of-home with applications to loneliness and physical activity.
Biomedical and Health Informatics, IEEE Journal of 18(5):1590 (2014)
Loneliness is a common condition in elderly associated with severe health consequences including increased mortality, decreased cognitive function, and poor quality of life. Identifying and assisting lonely individuals is therefore increasingly important-especially in the home setting-as the ver...
Tools for advancing research into social networks and cognitive function in older adults.
International Psychogeriatrics 26(4):533 (2014)
Associations between observed in-home behaviors and self-reported low mood in community-dwelling older adults.
Journal of the American Geriatrics Society 62(4):685 (2014)
To ascertain the association between self-report of low mood and unobtrusively measured behaviors (walking speed, time out of residence, frequency of room transitions, and computer use) in community-dwelling older adults using novel monitoring technologies.
Longitudinal cohort study of older adu...
Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects.
Neurobiology of Aging 35(2):357 (2014)
Low cerebrospinal fluid (CSF) Aβ(42) levels correlate with increased brain Aβ deposition in Alzheimer's disease (AD), which suggests a disruption in the degradation and clearance of Aβ from the brain. In addition, APOE ε4 carriers have lower CSF Aβ(42) levels than non-carriers. The hypothesis of...
Characteristics associated with willingness to participate in a randomized controlled behavioral clinical trial using home-based personal computers and a webcam.
Trials 15:508 (2014)
Trials aimed at preventing cognitive decline through cognitive stimulation among those with normal cognition or mild cognitive impairment are of significant importance in delaying the onset of dementia and reducing dementia prevalence. One challenge in these prevention trials is sample recruitme...
Longitudinal relaxographic imaging of white matter hyperintensities in the elderly.
Fluids and Barriers of the CNS 11:24 (2014)
Incidental white matter hyperintensities (WMHs) are common findings on T2-weighted magnetic resonance images of the aged brain and have been associated with cognitive decline. While a variety of pathogenic mechanisms have been proposed, the origin of WMHs and the extent to which lesions in the d...