1. Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy.

    Current Biology 25(5):546 (2015) PMID 25660547 PMCID PMC4348152

    Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated with severe pathologies, whereas unchecked autophagy activity causes...
  2. Rph1/KDM4 Mediates Nutrient-Limitation Signaling that Leads to the Transcriptional Induction of Autophagy

    Current Biology 25(5):546 (2015) PMID 25660547 PMCID PMC4348152

    Background Autophagy is a conserved process mediating vacuolar degradation and recycling. Autophagy is highly upregulated upon various stresses and is essential for cell survival in deleterious conditions. Autophagy defects are associated with severe pathologies, whereas unch...
  3. Cracking the survival code: autophagy-related histone modifications.

    Autophagy 10(4):556 (2014) PMID 24429873 PMCID PMC4091144

    Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the "apoptotic histone code" came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by...
  4. Cracking the survival code: autophagy-related histone modifications.

    Autophagy 10(4):556 (2014) PMID 24429873 PMCID PMC4091144

    Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the "apoptotic histone code" came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by...
  5. Cracking the survival code: autophagy-related histone modifications.

    Autophagy 10(4):556 (2014) PMID 24429873 PMCID PMC4091144

    Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the "apoptotic histone code" came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by...
  6. The return of the nucleus: transcriptional and epigenetic control of autophagy.

    Nature Reviews: Molecular Cell Biology 15(1):65 (2014) PMID 24326622

    Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigene...
  7. The return of the nucleus: transcriptional and epigenetic control of autophagy.

    Nature Reviews: Molecular Cell Biology 15(1):65 (2014) PMID 24326622

    Autophagy is a conserved process by which cytoplasmic components are degraded by the lysosome. It is commonly seen as a cytoplasmic event and, until now, nuclear events were not considered of primary importance for this process. However, recent studies have unveiled a transcriptional and epigene...
  8. Histone post-translational modifications regulate autophagy flux and outcome.

    Autophagy 9(10):1621 (2013) PMID 23934085

    Autophagy is an evolutionarily conserved process in eukaryotes by which cytoplasmic components including macromolecules and organelles are degraded by the lysosome/vacuole. Autophagy is implicated in a number of physiological processes important for human health and disease. Although primarily c...
  9. Histone post-translational modifications regulate autophagy flux and outcome.

    Autophagy 9(10):1621 (2013) PMID 23934085

    Autophagy is an evolutionarily conserved process in eukaryotes by which cytoplasmic components including macromolecules and organelles are degraded by the lysosome/vacuole. Autophagy is implicated in a number of physiological processes important for human health and disease. Although primarily c...
  10. Histone post-translational modifications regulate autophagy flux and outcome.

    Autophagy 9(10):1621 (2013) PMID 23934085

    Autophagy is an evolutionarily conserved process in eukaryotes by which cytoplasmic components including macromolecules and organelles are degraded by the lysosome/vacuole. Autophagy is implicated in a number of physiological processes important for human health and disease. Although primarily c...
  11. The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.

    Nature 500(7463):468 (2013) PMID 23863932 PMCID PMC4006103

    Autophagy is an evolutionarily conserved catabolic process involved in several physiological and pathological processes. Although primarily cytoprotective, autophagy can also contribute to cell death; it is thus important to understand what distinguishes the life or death decision in autophagic ...
  12. The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.

    Nature 500(7463):468 (2013) PMID 23863932 PMCID PMC4006103

    Autophagy is an evolutionarily conserved catabolic process involved in several physiological and pathological processes. Although primarily cytoprotective, autophagy can also contribute to cell death; it is thus important to understand what distinguishes the life or death decision in autophagic ...