1. The progressive nature of concentration camp syndrome in former prisoners of Nazi concentration camps--Not just history, but the important issue of contemporary medicine.

    Journal of Psychiatric Research 75:1 (2016) PMID 26783727

    Constant stress, slave labor, tortures, and starvation all affected the health of concentration camp prisoners, contributing to multimorbidities, increased mortality and accelerated development of chronic illnesses, what we have shown in an earlier publication. The interrelated somatic and psych...
  2. Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System.

    CNS and Neurological Disorders 15(3):329 (2016) PMID 26831258

    Chronic inflammation is characterized by longstanding microglial activation followed by sustained release of inflammatory mediators, which aid in enhanced nitrosative and oxidative stress. The sustained release of inflammatory mediators propels the inflammatory cycle by increased microglial acti...
  3. The Innate Immunity in Alzheimer Disease- Relevance to Pathogenesis and Therapy.

    Current Pharmaceutical Design 21(25):3582 (2015) PMID 26166611

    The genetic, cellular, and molecular changes associated with Alzheimer disease provide evidence of immune and inflammatory processes involvement in its pathogenesis. These are supported by epidemiological studies, which show some benefit of long-term use of NSAID. The hypothesis that AD is in fa...
  4. Evaluation of the posterior cingulate region with FDG-PET and advanced MR techniques in patients with amnestic mild cognitive impairment: comparison of the methods.

    Journal of Alzheimer's Disease 44(1):329 (2015) PMID 24614904

    The posterior cingulate region is an area of the earliest pathological changes in amnestic mild cognitive impairment (aMCI). The utility of FDG-PET imaging in dementia is already well established. The aim of the study was to compare FDG-PET with advanced MR measurements: MR spectroscopy (MRS), p...
  5. Impact of incarceration in Nazi concentration camps on multimorbidity of former prisoners.

    Neuropsychiatric Disease and Treatment 11:669 (2015) PMID 25792836 PMCID PMC4362975

    To show the extent to which the health of former prisoners was affected by incarceration in extermination camps after 5 and 30 years of leaving the camp, and to determine the etiological factors underlying particular dysfunctions. Medical records of former prisoners developed in 1950 (n=250) and...
  6. Vascular oxidative stress and mitochondrial failure in the pathobiology of Alzheimer's disease: a new approach to therapy.

    CNS and Neurological Disorders 12(6):870 (2013) PMID 23469836

    Vascular and metabolic dysfunctions and mitochondrial failure are now believed to be contributors to Alzheimer's disease (AD) pathogenesis. Vascular dysfunction includes reduced cerebral blood flow (CBF), blood-brain barrier (BBB) disturbances and cerebral amyloid angiopathy (CAA). Mitochondrial...
  7. Disturbances of innate immunity in Alzheimer's disease: Possible therapeutic approach

    Alzheimer's & Dementia 9(4):P350 (2013)

  8. The medical perspective on burnout.

    International Journal of Occupational Medicine ... 26(3):401 (2013) PMID 24018996

    The aim of this study was to review recent medical findings related to burnout, its diagnosis, treatment, characteristic pathophysiological features, and preventive measures. A systematic review of the scientific literature in PubMed/Medline was performed. The most recent and important findings ...
  9. Alterations in molecular status of plasma fibronectin associated with aging of normal human individuals.

    Clinical Biochemistry 46(9):787 (2013) PMID 23518314

    Senescence, progressive deterioration of many bodily functions might be associated with age-dependent alterations of plasma fibronectin (FN) molecular status (i.e., domain, glycotope, and molecular form expressions). FN molecular status was analyzed in 127 plasma samples of healthy individuals i...
  10. Quantitative MR evaluation of atrophy, as well as perfusion and diffusion alterations within hippocampi in patients with Alzheimer's disease and mild cognitive impairment.

    Medical Science Monitor 19:86 (2013) PMID 23377218 PMCID PMC3628917

    The aim of this study was to evaluate atrophy rates, perfusion, and diffusion disturbances within the hippocampus, which is the site of characteristic changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Thirty patients with AD (mean age 71.2 yrs) - 34 with MCI (mean age 67.7...
  11. Vascular factors and epigenetic modifications in the pathogenesis of Alzheimer's disease.

    Journal of the Neurological Sciences 323(1-2):25 (2012) PMID 23026534

    Alzheimer's disease (AD) is a debilitating illness with no known cure. Nowadays accumulating evidence suggested that the vascular endothelium and chronic hypoperfusion may play important role in pathobiology of AD. The vascular endothelium which regulates the passage of macromolecules and circul...
  12. Metabolic syndrome, mild cognitive impairment and Alzheimer's disease--the emerging role of systemic low-grade inflammation and adiposity.

    Brain Research Bulletin 89(3-4):144 (2012) PMID 22921944

    The past decade has shed new light on the etiology of Alzheimer's disease (AD), which is the consequence of interactions between numerous lesions. There is a growing body of evidence that the most beneficial effects of treatment might only be achieved in the preclinical stage of dementia, prior ...
  13. Disturbances of innate immunity in Alzheimer's disease: Possible therapeutic approach

    Alzheimer's & Dementia 8(4):P301 (2012)

  14. Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.

    International Journal of Alzheimer's Disease 2012:518901 (2012) PMID 22482072 PMCID PMC3312254

    Dementia is a major problem of health in developed societies. Alzheimer's disease (AD), vascular dementia, and mixed dementia account for over 90% of the most prevalent forms of dementia. Both genetic and environmental factors are determinant for the phenotypic expression of dementia. AD is a co...
  15. Age- and disease-related innate immunity of human leukocytes ex vivo.

    Experimental Gerontology 47(1):8 (2012) PMID 21983494

    Two mechanisms of innate immunity, i.e. resistance to viral infection and the production of cytokines by leukocytes, were compared in blood isolated from four groups of donors: healthy young (19-35 years old), healthy elderly (over 60), elderly Alzheimer's disease (AD) patients, and elderly pati...
  16. Oxidative stress-induced mitochondrial DNA overproliferation and deletion, cellular hypoperfusion and brain hypometabolism in the context of Alzheimer's disease: past, present and future

    Alzheimer's & Dementia 7(4):S305 (2011)

  17. Higher expressions of macromolecular forms and C-terminal domain of plasma fibronectin more frequently associated with Alzheimer's disease

    Alzheimer's & Dementia 7(4):e14 (2011)

  18. Mitochondrion-specific antioxidants as drug treatments for Alzheimer disease.

    CNS and Neurological Disorders 10(2):149 (2011) PMID 21222631

    Age-related dementias such as Alzheimer disease (AD) have been linked to vascular disorders like hypertension, diabetes and atherosclerosis. These risk factors cause ischemia, inflammation, oxidative damage and consequently reperfusion, which is largely due to reactive oxygen species (ROS) that ...
  19. Implication of oncogenic signaling pathways as a treatment strategy for neurodegenerative disorders - contemporary approaches.

    CNS and Neurological Disorders 10(2):175 (2011) PMID 21222633

    Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal cell vulnerability in Alzheimer's and Parkinson's diseases, as a common chronic neurodegeneration. This phenomenon associated with oncogenic transduction pathway activation ha...
  20. Antioxidants in health, disease and aging.

    CNS and Neurological Disorders 10(2):192 (2011) PMID 21226664

    There is growing scientific agreement that antioxidants, particularly the polyphenolic forms, may help lower the incidence of disease, such as certain cancers, cardiovascular and neurodegenerative diseases, DNA damage, or even have anti-aging properties. On the other hand, questions remain as to...