MiR-10b decreases sensitivity of glioblastoma cells to radiation by targeting AKT.
Journal of biological research 23:14 (2016)
Glioblastomas are the most aggressive brain tumors with extremely poor prognosis despite advances in treatment techniques. MiR-10b is highly expressed in glioblastoma and regulates cell proliferation, migration and invasion. Here, we examined the role of MiR-10b on radiotherapy of glioblastomas....
Graphene oxide/cellulose aerogels nanocomposite: Preparation, pyrolysis, and application for electromagnetic interference shielding.
Carbohydrate polymers 150:172 (2016)
Hybrid aerogels consisting of graphene oxide (GO) and cellulose were prepared via a solution mixing-regeneration-freeze drying process. The presence of GO affected the micromorphology of the hybrid aerogels, and a self-assembly behavior of cellulose was observed after the incorporation of GO. Mo...
Electrochemical sensor for dopamine based on imprinted silica matrix-poly(aniline boronic acid) hybrid as recognition element.
Talanta 159:379 (2016)
A novel imprinted silica matrix-poly(aniline boronic acid) hybrid for electrochemical detection of dopamine (DA) was developed. Boronic acid functionalized conducting polymer was electrochemically prepared on Au electrode. The number of covalent binding sites toward DA templates was controlled b...
miR-222 confers the resistance of breast cancer cells to Adriamycin through suppression of p27(kip1) expression.
Gene 590(1):44 (2016)
Adriamycin (Adr) is a potent chemotherapeutic agent for chemotherapy of breast cancer patients. Despite impressive initial clinical responses, some developed drug resistance to Adr-based therapy and the mechanisms underlying breast cancer cells resistance to Adr are not well known. In our previo...
Fluoride induced endoplasmic reticulum stress and calcium overload in ameloblasts.
Archives of Oral Biology 69:95 (2016)
The aim of the study was to evaluate the involvement of endoplasmic reticulum stress and intracellular calcium overload on the development of dental fluorosis.
We cultured and exposed rat ameloblast HAT-7 cells to various concentrations of fluoride and measured apoptosis with flow cytometry and ...
Overexpression of sugarcane gene SoSnRK2.1 confers drought tolerance in transgenic tobacco.
Plant Cell Reports 35(9):1891 (2016)
Overexpression of SoSnRK2.1 improved drought tolerance and growth of tobacco plants. Sucrose non-fermenting1-related protein kinase 2 (SnRK2) is a key enzyme in regulating ABA signal transduction in plants, and it plays a significant role in response to multiple abiotic stresses. In this researc...
Exploiting the Reactivity of Isocyanide: Coupling Reaction between Isocyanide and Toluene Derivatives Using the Isocyano Group as an N1 Synthon.
Organic Letters 18(16):4052 (2016)
An unusual oxidative coupling reaction of isocyanide and toluene derivatives using tetrabutylammonium iodide (TBAI) as a catalyst is disclosed. The experimental results and mechanistic study show that the isocyano group acts formally as an N1 synthon during the transformation, thus expanding the...
Tuning the emission properties of a fluorescent polymer using a polymer microarray approach - identification of an optothermo responsive polymer.
Chemical Communications 52(69):10521 (2016)
Polymer microarrays were prepared using inkjet printing mixtures of acrylate monomers each with a common fluorescent fluorene co-polymer. Fluorescence analysis of each of the features on the array allowed identification of polymers that could tune the fluorescence under a variety of insults. The...
Tanshinone IIA decreases the levels of inflammation induced by Aβ1-42 in brain tissues of Alzheimer's disease model rats.
Neuroreport 27(12):883 (2016)
To study the pathogenesis of Alzheimer's disease (AD) and explore the possible anti-inflammatory mechanism of tanshinone IIA (TanIIA), we evaluated the quantity of neurons and the expression levels of interleukin-1β (IL-1β), IL-6, glial fibrillary acidic protein, CD11b, C1q, C3c, and C3d in brai...
Tuning Slow Magnetic Relaxation in a Two-Dimensional Dysprosium Layer Compound through Guest Molecules.
Inorganic Chemistry 55(16):7980 (2016)
A novel two-dimensional dysprosium(III) complex, [Dy(L)(CH3COO)]·0.5DMF·H2O·2CH3OH (1), has been successfully synthesized from a new pyridine-N-oxide (PNO)-containing ligand, namely, N'-(2-hydroxy-3-methoxybenzylidene)pyridine-N-oxidecarbohydrazide (H2L). Single-crystal X-ray diffraction studies...
New Opportunity for in Situ Exsolution of Metallic Nanoparticles on Perovskite Parent.
Nano Letters 16(8):5303 (2016)
One of the main challenges for advanced metallic nanoparticles (NPs) supported functional perovskite catalysts is the simultaneous achievement of a high population of NPs with uniform distribution as well as long-lasting high performance. These are also the essential requirements for optimal ele...
Conventional kinesin KIF5B mediates adiponectin secretion in 3T3-L1 adipocytes.
Biochemical and Biophysical Research Communicat... 476(4):620 (2016)
Insulin stimulates adiponectin secretion and glucose transporter type 4 (GLUT4) translocation in adipocyte to regulate metabolism homeostasis. Similar to GLUT4 translocation, intracellular trafficking and release of adiponectin in adipocytes relies on the trans-Golgi network and endosomal system...
Cellulose aerogels functionalized with polypyrrole and silver nanoparticles: In-situ synthesis, characterization and antibacterial activity.
Carbohydrate polymers 146:362 (2016)
Green porous and lightweight cellulose aerogels have been considered as promising candidates to substitute some petrochemical host materials to support various nanomaterials. In this work, waste wheat straw was collected as feedstock to fabricate cellulose hydrogels, and a green inexpensive NaOH...
Estrogen and thyroid diseases: an update.
Minerva medica 107(4):239 (2016)
Most of thyroid diseases show female predilection, especially autoimmune thyroid diseases (AITD) and thyroid cancer (TC). We give an updated brief review here, focusing on estrogen, estrogen receptor (ER) and AITD as well as TC. Estrogen can regulate the functions of nearly all immunocyte subset...
Aliskiren protecting atrial structural remodeling from rapid atrial pacing in a canine model.
Naunyn-Schmiedebergs Archives of Pharmacology 389(8):863 (2016)
Atrial fibrillation (AF) contributing to the increasing mortality risk is the most common disease in clinical practice. Owing to the side effects and relative inefficacy of current antiarrhythmic drugs, some research focuses on renin-angiotensin-aldosterone system (RAS) for finding out the new t...
Intra-uterine undernutrition amplifies age-associated glucose intolerance in pigs via altered DNA methylation at muscle GLUT4 promoter.
British Journal of Nutrition 116(3):390 (2016)
The present study aimed to investigate the effect of maternal malnutrition on offspring glucose tolerance and the epigenetic mechanisms involved. In total, twelve primiparous Landrace×Yorkshire gilts were fed rations providing either 100 % (control (CON)) or 75 % (undernutrition (UN)) nutritiona...
Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells.
Oncology Reports 36(2):1180 (2016)
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a human oncoprotein that is overexpressed in various tumors. A previous study found that CIP2A expression is associated with doxorubicin (Dox) resistance. In the present study, we investigated whether cucurbitacin B (CuB), a natural antica...
Enhancement of biomass conversion in catalytic fast pyrolysis by microwave-assisted formic acid pretreatment.
Bioresource Technology 214:520 (2016)
This study investigated microwave-assisted formic acid (MW-FA) pretreatment as a possible way to improve aromatic production from catalytic fast pyrolysis (CFP) of lignocellulosic biomass. Results showed that short duration of MW-FA pretreatment (5-10min) could effectively disrupt the recalcitra...
Pathological damage and immunomodulatory effects of zebrafish exposed to microcystin-LR.
Toxicon 118:13 (2016)
Cyanobacterial blooms caused by water eutrophication have become a worldwide problem. Microcystins (MCs), especially microcystin-LR (MC-LR), released during cyanobacterial blooms exert great toxicity on fish and even lead to massive death. The present study mainly investigated the pathological d...
bFGF- and CaPP-Loaded Fibrin Clots Enhance the Bioactivity of the Tendon-Bone Interface to Augment Healing.
American Journal of Sports Medicine 44(8):1972 (2016)
Tendon-to-bone healing is a complex and slow process, and the rate of poor healing remains high. In recent years, several new strategies have been developed that enhance tendon-to-bone healing by increasing the bioactivity. Fibrin clots have been widely used to improve tissue healing and tissue ...