1. Circulating Prolactin and Risk of Type 2 Diabetes: A Prospective Study.

    American Journal of Epidemiology 184(4):295 (2016) PMID 27466075

    Prolactin plays an important role in maintaining a normal glucose homeostasis during pregnancy and beyond. Studies investigating the association between prolactin and type 2 diabetes beyond pregnancy are rare and none is prospective. We aimed to examine whether prolactin associates with type 2 d...
  2. Curbing the obesity epidemic in China.

    The lancet. Diabetes & endocrinology 4(6):470 (2016) PMID 27133171

  3. Plasma glucose and hemoglobin A1c for the detection of diabetes in Chinese adults.

    Journal Of Diabetes 8(3):378 (2016) PMID 25940519

    The aim of the present study was to evaluate the performance of plasma glucose (PG) and HbA1c for the detection of diabetes in the general population in China. A cross-sectional analysis was conducted in a nationally representative sample of 98,658 Chinese adults aged ≥18 years. Fasting plasma g...
  4. Associations of smoking and alcohol consumption with impaired β-cell function in Chinese men.

    Journal Of Diabetes 8(3):434 (2016) PMID 25991060

    The aims of the present study were to examine the association of cigarette smoking and alcohol consumption with impaired β-cell function in Chinese men, particularly the interaction of smoking and alcohol consumption on impaired insulin secretion. A population-based cross-sectional study was per...
  5. Paternal Psychological Stress Reprograms Hepatic Gluconeogenesis in Offspring.

    Cell Metabolism 23(4):735 (2016) PMID 26908462

    Both epidemiologic and experimental animal studies demonstrate that chronic psychological stress exerts adverse effects on the initiation and/or progression of many diseases. However, intergenerational effects of this environmental information remains poorly understood. Here, using a C57BL/6 mou...
  6. Type 2 Diabetes, Diabetes Genetic Score and Risk of Decreased Renal Function and Albuminuria: A Mendelian Randomization Study.

    EBioMedicine 6:162 (2016) PMID 27211558 PMCID PMC4856750

    Type 2 diabetes (T2D) is a risk factor for dysregulation of glomerular filtration rate (GFR) and albuminuria. However, whether the association is causal remains unestablished. We performed a Mendelian Randomization (MR) analysis in 11,502 participants aged 40 and above, from a well-defined commu...
  7. Insulin Resistance is Associated With Total Bile Acid Level in Type 2 Diabetic and Nondiabetic Population: A Cross-Sectional Study.

    Medicine (Baltimore) 95(10):e2778 (2016) PMID 26962776

    Bile acid metabolism was reported to be involved in glucose metabolism homeostasis. However, the exact relationship between bile acid and glucose metabolism as well as insulin sensitivity is not clarified. Therefore, we sought to investigate the association between insulin sensitivity and hyperb...
  8. Association between the change in body mass index from early adulthood to midlife and subsequent type 2 diabetes mellitus.

    Obesity 24(3):703 (2016) PMID 26833544

    To clarify the quantitative relationship of body mass index (BMI) change from early adulthood to midlife with presence of type 2 diabetes mellitus (T2DM) after midlife. This study included 120,666 middle-aged and elderly, whose retrospectively self-reported body weight at 20 and 40 years and mea...
  9. Association of Serum Fetuin-A Levels With the Risk of Albuminuria in Middle-Aged and Elderly Chinese.

    Journal of Clinical Endocrinology & Metabolism 101(3):1235 (2016) PMID 26756112

    Fetuin-A is an important hepatokine associated with many cardiometabolic abnormities. The association between fetuin-A and albuminuria has not been investigated in a prospective cohort. The objective of the study was to prospectively investigate whether serum fetuin-A levels were associated with...
  10. Diabetes-related metabolic risk factors in internal migrant workers in China: a national surveillance study.

    The lancet. Diabetes & endocrinology 4(2):125 (2016) PMID 26776861

    Little is known about the cardiometabolic health of internal migrant workers in China. We aimed to examine the prevalence of diabetes-related cardiometabolic risk factors in this large, but little-studied population. We did this national surveillance study within the Chinese Center for Disease C...
  11. Diabetes Genetic Risk Score Modifies Effect of Bisphenol A Exposure on Deterioration in Glucose Metabolism.

    Journal of Clinical Endocrinology & Metabolism 101(1):143 (2016) PMID 26523527

    Epidemiology studies showed inconsistent results regarding the relationship between bisphenol A (BPA) exposure and risk of type 2 diabetes (T2D). This study sought to prospectively investigate associations of BPA with incident T2D risk and the longitudinal changes in glycemic traits, particularl...
  12. Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study.

    Journal of the American Heart Association Cardi... 5(7) (2016) PMID 27451464

    Chronic kidney disease (CKD) increases cardiovascular disease (CVD) risk. However, the association of mildly reduced kidney function with CVD risk is unclear. This study investigated the association of estimated glomerular filtration rate (eGFR) with prevalent CVDs, 10-year Framingham risk for c...
  13. Risk of all-cause mortality and cardiovascular disease associated with secondhand smoke exposure: a systematic review and meta-analysis.

    International Journal of Cardiology 199:106 (2015) PMID 26188829

    Emerging studies have assessed the association between secondhand smoke (SHS) exposure and cardiovascular disease (CVD) as well as all-cause mortality. However, findings were not consistent due to the heterogeneity of study characteristics. PubMed and Embase were searched through May 2014 for pr...
  14. Prevalence and trends in overweight and obesity among Chinese adults in 2004–10: data from three nationwide surveys in China

    The Lancet 386:S77 (2015)

    Background Obesity has become a global epidemic and is a common risk factor for many chronic diseases. Few data for the prevalence and trends in overweight and obesity in Chinese adults have been obtained over the past decade. We aimed to estimate changes in the prevalence of...
  15. Prevalence, awareness, treatment, and control of diabetes in relation to hypertension status in Chinese adults: a nationwide cross-sectional survey

    The Lancet 386:S55 (2015)

    Background Previous studies have shown that hypertension is an important risk factor for diabetes, and the coexistence of hypertension and diabetes can substantially increase morbidity and mortality of cardiovascular disease. The aim of this study was to estimate the prevalen...
  16. Association of Bisphenol A Exposure With Hypertension and Early Macrovascular Diseases in Chinese Adults: A Cross-Sectional Study.

    Medicine (Baltimore) 94(43):e1814 (2015) PMID 26512580

    Bisphenol A (BPA) is an environmental endocrine disruptor that has been associated with cardiovascular outcomes in previous observational studies. We aimed to examine the relationships of urinary BPA levels with hypertension and early macrovascular diseases.This is a cross-sectional study. From ...
  17. Adipose tissue distribution is associated with glycaemic control and microalbuminuria in Chinese patients with type 2 diabetes: a cross-sectional study

    The Lancet 386:S54 (2015)

    Background Abdominal adipose tissue has an important role in the development of type 2 diabetes. It has also been suggested to be involved in the prognosis of the disease. Therefore, this study aimed to investigate the association between adipose tissue distribution by anthro...
  18. Validation of the Fatty Liver Index for Nonalcoholic Fatty Liver Disease in Middle-Aged and Elderly Chinese.

    Medicine (Baltimore) 94(40):e1682 (2015) PMID 26448014 PMCID PMC4616754

    The fatty liver index (FLI), which is an algorithm based on waist circumference, body mass index (BMI), triglyceride, and gamma-glutamyl-transferase (GGT), was initially developed to detect fatty liver in Western countries. Our study aimed to evaluate the accuracy and optimal cut-off point of th...
  19. Diabetes genetic score, diabetes, and arterial stiffness: a Mendelian randomisation analysis in Chinese

    The Lancet 386:S53 (2015)

    Background The nature and underlying mechanisms of the association between type 2 diabetes and the risk of increased arterial stiffness are unclear. We aimed to study this association using the Mendelian randomisation approach.
  20. Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese.

    Journal of Atherosclerosis and Thrombosis 22(8):823 (2015) PMID 25740202

    The carotid intima-media thickness (CIMT) is now validated as a sensitive marker of atherosclerosis and is directly associated with an increased risk of cardiovascular disease. Considering that the independent association between the serum uric acid level and CIMT remains controversial due to th...
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