1. Advances in characterisation and biological activities of chitosan and chitosan oligosaccharides.

    Food Chemistry 190:1174 (2016) PMID 26213092

    Chitosan and chitosan oligosaccharides (COS) have been reported to possess various biomedical properties, including antimicrobial activities, immuno-enhancing effects, and anti-tumour activities. COS have attracted considerable interest due to their physicochemical properties, and potential appl...
  2. A receptor like kinase gene with expressional responsiveness on Xanthomonas oryzae pv. oryzae is essential for Xa21-mediated disease resistance.

    Rice 8(1):34 (2015) PMID 26054238

    Leucine-rich repeat receptor-like kinases (LRR-RLKs) represent a large class of proteins in regulating plant development and immunity. The LRR-RLK XA21 confers resistance to the bacterial disease caused by the pathogen of Xanthomonas oryzae pv. oryzae (Xoo). Several XA21 binding proteins have be...
  3. Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer.

    International Journal of Cancer 137(7):1587 (2015) PMID 25821004

    We previously elucidated the pleotropic role of solute carrier family A1 member 5 (SLC1A5) as the primary transporter of glutamine (Gln), a modulator of cell growth and oxidative stress in non-small cell lung cancer (NSCLC). The aim of our study was to evaluate SLC1A5 as a potential new therapeu...
  4. Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.

    Molecular Medicine Reports 12(3):4187 (2015) PMID 26096149

    The aim of the present study was to evaluate the effects of the B7/cluster of differentiation (CD)28 signaling pathway on experimental lupus nephritis and examine the molecular mechanism involved by inhibiting the B7/CD28 signaling pathway. A lupus nephritis model in C57BL/6 J mice was induced v...
  5. Vascular endothelial growth factor affects dendritic cell activity in hypertensive disorders of pregnancy.

    Molecular Medicine Reports 12(3):3781 (2015) PMID 25975204

    Vascular endothelial growth factor (VEGF) activity is involved in the growth and stability of the placenta, and its signaling has been implicated in the development of pregnancy‑induced hypertension (PIH). The present study sought to evaluate VEGF levels and dendritic cell (DC) profiles in patie...
  6. Simultaneous determination of four organotins in food packaging by high-performance liquid chromatography–tandem mass spectrometry

    Food Chemistry 181:347 (2015)

    • An HPLC–MS/MS method is developed to detect organotins in plastic food packaging. • The method allows for simultaneous detection for 4 organotins in plastic pack...
  7. The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy.

    Archives of Biochemistry and Biophysics 580:84 (2015) PMID 26151775

    Glioblastoma multiforme (GBM) is thought to result from an imbalance between glucose metabolism and tumor growth. The Myc oncogene and lethal-7a microRNA (let-7a miRNA) have been suggested to cooperatively regulate multiple downstream targets leading to changes in chromosome stability, gene muta...
  8. Simultaneous determination of four organotins in food packaging by high-performance liquid chromatography–tandem mass spectrometry

    Food Chemistry 181:347 (2015) PMID 25794760

    • An HPLC–MS/MS method is developed to detect organotins in plastic food packaging. • The method allows for simultaneous detection for 4 organotins in plastic pack...
  9. Ubiquitin E3 ligase UHRF1 regulates p53 ubiquitination and p53-dependent cell apoptosis in clear cell Renal Cell Carcinoma.

    Biochemical and Biophysical Research Communicat... 464(1):147 (2015) PMID 26102039

    Ubiquitin-like with PHD and RING finger domain 1 (UHRF1) is a multi-domain ubiquitin E3 ligase that plays critical roles in regulation of DNA methylation and histone ubiquitination. In this study, we found UHRF1 is frequently overexpressed in human clear cell Renal Cell Carcinoma (ccRCC) tissues...
  10. Bayesian estimation on diagnostic performance of Face, Legs, Activity, Cry, and Consolability and Neonatal Infant Pain Scale for infant pain assessment in the absence of a gold standard.

    Pediatric Anesthesia 25(8):834 (2015) PMID 25929312

    Nonverbal pediatric patients such as infants are unable to describe their pain, which leads to the lack of a gold standard scale for their pain assessment. The aim of this study was to estimate the diagnostic performance of Face, Legs, Activity, Cry, and Consolability (FLACC) scale and Neonatal ...
  11. Upregulation of neuroglobin expression and changes in serum redox indices in a rat model of middle cerebral artery occlusion.

    Molecular Medicine Reports 12(2):1693 (2015) PMID 25847303 PMCID PMC4464340

    Neuroglobin (NGB) is a recently identified protein, which is localized in the neurons and retinal cells of the central and peripheral nervous systems in vertebrates. It is hypothesized to function as a scavenger for reactive oxygen species, or as a stress‑responsive sensor for signal transductio...
  12. Effects of dietary vitamin C supplementation on lead-treated sea cucumbers, Apostichopus japonicus.

    Ecotoxicology and Environmental Safety 118:21 (2015) PMID 25890051

    This study aimed to determine the effects of dietary supplementation with vitamin C (l-ascorbic acid, AsA) on lead (Pb) accumulation and toxicity in sea cucumber, Apostichopus japonicus. Three hundred sea cucumbers (10.02±0.02g) fed a basal diet containing 100mg Pb/kg were subjected to 5 levels ...
  13. CD163+CD14+ macrophages, a potential immune biomarker for malignant pleural effusion.

    Cancer Immunology, Immunotherapy 64(8):965 (2015) PMID 25944005

    Malignant pleural effusion (MPE) is a common complication caused by malignant diseases. However, subjectivity, poor sensitivity, and substantial false-negative rates of cytology assay hamper accurate MPE diagnosis. The aim of this study was to assess whether CD163+CD14+ tumor-associated macropha...
  14. Extended followup of a cohort of chromium production workers.

    American Journal of Industrial Medicine 58(8):905 (2015) PMID 26041683

    The current study evaluates the mortality of 2,354 workers first employed at a Baltimore chromate production plant between 1950 and 1974. The National Death Index (NDI Plus) was used to determine vital status and cause of death. Cumulative chromium (VI) exposure and nasal and skin irritation wer...
  15. Dissecting Human Gene Functions Regulating Islet Development With Targeted Gene Transduction.

    Diabetes 64(8):3037 (2015) PMID 25901096 PMCID PMC4512220

    During pancreas development, endocrine precursors and their progeny differentiate, migrate, and cluster to form nascent islets. The transcription factor Neurogenin 3 (Neurog3) is required for islet development in mice, but its role in these dynamic morphogenetic steps has been inferred from fixe...
  16. Left ventricular systolic intraventricular flow field assessment in hyperthyroidism patients using vector flow mapping.

    Journal of Huazhong University of Science and T... 35(4):574 (2015) PMID 26223930

    Intraventricular hydrodynamics is considered an important component of cardiac function assessment. Vector flow mapping (VFM) is a novel flow visualization method to describe cardiac pathophysiological condition. This study examined use of new VFM and flow field for assessment of left ventricula...
  17. Heat shock protein 70 is associated with CSFV NS5A protein and enhances viral RNA replication.

    Virology 482:9 (2015) PMID 25827528

    The non-structural 5A (NS5A) protein of classical swine fever virus (CSFV) is proven to be involved in viral replication and can also modulate cellular signaling via to its ability to interact with various cellular proteins. Here, HSP70/NS5A complex formation is confirmed by coimmunoprecipitatio...
  18. ERK5 signalling pathway is essential for fluid shear stress-induced COX-2 gene expression in MC3T3-E1 osteoblast.

    Molecular and Cellular Biochemistry 406(1-2):237 (2015) PMID 25976667

    Bone cells respond to various mechanical stimuli including fluid shear stress (FSS) in vitro. Induction of cyclooxygenase-2 (COX-2) is thought to be important for the anabolic effects of mechanical loading. Recently, extracellular-signal-regulated kinase 5 (ERK5) has been found to be involved in...
  19. The efficacy of steroid injection in total knee or hip arthroplasty.

    Knee Surgery, Sports Traumatology, Arthroscopy 23(8):2306 (2015) PMID 24841939

    A systematic review and meta-analysis based on randomized controlled trials (RCTs) was conducted to evaluate the efficacy and safety of steroid injection in total knee or hip arthroplasty (TKA/THA). A systematical electronic search identified the relevant RCTs in the databases of PubMed, EMBASE,...
  20. Laser-induced interstitial thermotherapy via a single-needle delivery system: Optimal conditions of ablation, pathological and ultrasonic changes.

    Journal of Huazhong University of Science and T... 35(4):579 (2015) PMID 26223931

    This study aimed to examine the optimal conditions of laser-induced interstitial thermotherapy (LITT) via a single-needle delivery system, and the ablation-related pathological and ultrasonic changes. Ultrasound (US)-guided LITT (EchoLaser system) was performed at the output power of 2-4 Wattage...