1. The Homeoprotein DLX4 Stimulates NF-κB Activation and CD44-Mediated Tumor-Mesothelial Cell Interactions in Ovarian Cancer.

    The American Journal of Pathology 185(8):2298 (2015) PMID 26067154

    Ovarian cancers often highly express inflammatory cytokines and form implants throughout the peritoneal cavity. However, the mechanisms that drive inflammatory signaling and peritoneal metastasis of ovarian cancer are poorly understood. We previously identified that high expression of DLX4, a tr...
  2. 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose.

    Bioorganic & Medicinal Chemistry 23(13):3751 (2015) PMID 25910584

    The estrogen-related receptor γ (ERRγ) is a potential molecular target for the development of small molecules to stimulate the adipose browning process, which may represent a novel attractive strategy to treat obesity related disorders. The receptor possesses a very small ligand binding cavity a...
  3. Conformational change study of dengue virus NS2B-NS3 protease using 19F NMR spectroscopy.

    Biochemical and Biophysical Research Communicat... 461(4):677 (2015) PMID 25918021

    The dengue virus NS2B-NS3 protease (NS2B-NS3p), an important antiviral target for drug development, has been reported to adopt an open or closed conformation in crystal structures with different NS2B C-terminus (NS2Bc) positioning. In solution, nevertheless, NS2B-NS3p forms a mixture of open, cl...
  4. Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.

    Bioorganic & Medicinal Chemistry Letters 25(7):1541 (2015) PMID 25724825

    A series of 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease (AD). The results showed that the target compounds exhibited good acetylcholinesterase (AChE) inhibitory potencies, high selecti...
  5. The p.Ser267Phe variant in SLC10A1 is associated with resistance to chronic hepatitis B.

    Hepatology 61(4):1251 (2015) PMID 25418280

    In the past 50 years there have been considerable efforts to identify the cellular receptor of hepatitis B virus (HBV). Recently, in vitro evidence from several groups has shown that the sodium-taurocholate cotransporting polypeptide (NTCP, which is encoded by SLC10A1 and transports bile acids i...
  6. Low-temperature solid-state synthesis and optical properties of ZnO/CdS nanocomposites

    Journal of Alloys and Compounds 618:67 (2015)

    • Using a low-temperature solid-state method, ZnO/CdS nanocomposites were obtained • Grain growth kinetics of cubic CdS and hexagonal ZnO phase was described. ...
  7. MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer.

    Journal of Pathology 235(1):25 (2015) PMID 25230372 PMCID PMC4268369

    Extensive investigations have shown that miRNAs are important regulators of epithelial-to-mesenchymal transition (EMT), mainly targeting the transcriptional repressors of E-cadherin (E-cad). Less is known about the post-transcriptional regulation of vimentin or N-cadherin (N-cad) in EMT. Our pre...
  8. Erratum to: Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence.

    Breast Cancer Research (Online Edition) 17(1):87 (2015) PMID 26108797 PMCID PMC4480452

  9. MiR-506 inhibits multiple targets in the epithelial-to-mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer.

    Journal of Pathology 235(1):25 (2015) PMID 25230372 PMCID PMC4268369

    Extensive investigations have shown that miRNAs are important regulators of epithelial-to-mesenchymal transition (EMT), mainly targeting the transcriptional repressors of E-cadherin (E-cad). Less is known about the post-transcriptional regulation of vimentin or N-cadherin (N-cad) in EMT. Our pre...
  10. CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis.

    PLoS ONE 10(7):e0131833 (2015) PMID 26146988 PMCID PMC4492679

    Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ovarian cancers. Multiple ovarian cancer cell li...
  11. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis.

    Proteins: Structure, Function and Bioinformatics 82(12):3483 (2014) PMID 25212774

    Sorting nexin 10 (SNX10), the unique member of the SNX family having vacuolation activity in cells, was shown to be involved in the development of autosomal recessive osteopetrosis (ARO) in recent genetic studies. However, the molecular mechanism of the disease-related mutations affecting the bi...
  12. Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis.

    Proteins: Structure, Function and Bioinformatics 82(12):3483 (2014) PMID 25212774

    Sorting nexin 10 (SNX10), the unique member of the SNX family having vacuolation activity in cells, was shown to be involved in the development of autosomal recessive osteopetrosis (ARO) in recent genetic studies. However, the molecular mechanism of the disease-related mutations affecting the bi...
  13. Dynamic trapping of terahertz waves by silicon-filled metallic grating structure

    Optics Communications 332:132 (2014)

    We investigate the feasibility of dynamic trapping of terahertz waves using a silicon-filled metallic grating structure. Using the dispersion relation analysis and the two-dimensional finite element method simulations, we reveal that, if a graded refractive index distribution in the gr...
  14. Dynamic trapping of terahertz waves by silicon-filled metallic grating structure

    Optics Communications 332:132 (2014)

    We investigate the feasibility of dynamic trapping of terahertz waves using a silicon-filled metallic grating structure. Using the dispersion relation analysis and the two-dimensional finite element method simulations, we reveal that, if a graded refractive index distribution in the gr...
  15. Bi-directionally selective bone targeting delivery for anabolic and antiresorptive drugs: A novel combined therapy for osteoporosis?

    Medical Hypotheses 83(6):694 (2014)

    Osteoporosis is a progressive systemic skeletal disease, in which the equilibrium of bone resorption and bone formation is disturbed. The drugs for osteoporosis can be divided into two categories according to their predominant effects: antiresorptive drugs and anabolic drugs. Antiresor...
  16. Dynamic trapping of terahertz waves by silicon-filled metallic grating structure

    Optics Communications 332:132 (2014)

    We investigate the feasibility of dynamic trapping of terahertz waves using a silicon-filled metallic grating structure. Using the dispersion relation analysis and the two-dimensional finite element method simulations, we reveal that, if a graded refractive index distribution in the gr...
  17. Bi-directionally selective bone targeting delivery for anabolic and antiresorptive drugs: A novel combined therapy for osteoporosis?

    Medical Hypotheses 83(6):694 (2014) PMID 25459136

    Osteoporosis is a progressive systemic skeletal disease, in which the equilibrium of bone resorption and bone formation is disturbed. The drugs for osteoporosis can be divided into two categories according to their predominant effects: antiresorptive drugs and anabolic drugs. Antiresorptive drug...
  18. Dynamic trapping of terahertz waves by silicon-filled metallic grating structure

    Optics Communications 332:132 (2014)

    We investigate the feasibility of dynamic trapping of terahertz waves using a silicon-filled metallic grating structure. Using the dispersion relation analysis and the two-dimensional finite element method simulations, we reveal that, if a graded refractive index distribution in the gr...
  19. Dynamic trapping of terahertz waves by silicon-filled metallic grating structure

    Optics Communications 332:132 (2014)

    We investigate the feasibility of dynamic trapping of terahertz waves using a silicon-filled metallic grating structure. Using the dispersion relation analysis and the two-dimensional finite element method simulations, we reveal that, if a graded refractive index distribution in the gr...
  20. Dynamic trapping of terahertz waves by silicon-filled metallic grating structure

    Optics Communications 332:132 (2014)

    We investigate the feasibility of dynamic trapping of terahertz waves using a silicon-filled metallic grating structure. Using the dispersion relation analysis and the two-dimensional finite element method simulations, we reveal that, if a graded refractive index distribution in the gr...