1. Publishing Science in the Time of Zika.

    Cell 165(5):1029 (2016) PMID 27203101

  2. Involvement of mitochondrial proteins in calcium signaling and cell death induced by staurosporine in Neurospora crassa.

    Biochimica et Biophysica Acta 1847(10):1064 (2015) PMID 26004627

    Staurosporine-induced cell death in Neurospora crassa includes a well defined sequence of alterations in cytosolic calcium levels, comprising extracellular Ca(2+) influx and mobilization of Ca(2+) from internal stores. Here, we show that cells undergoing respiratory stress due to the lack of cer...
  3. Timeline: Checkpoint Blockade

    Cell 162(6):1434 (2015) PMID 26359994

    Immune checkpoint therapy, targeting inhibitory pathways in T cells to unleash antitumor immune responses, has led to amazing advances in the clinical care of patients with highly aggressive and otherwise-untreatable cancers. Paraphrasing Jim Allison, the recipient of the 2015 Lasker-D...
  4. Patient Activity and Survival Following Implantable Cardioverter-Defibrillator Implantation: The ALTITUDE Activity Study.

    Journal of the American Heart Association Cardi... 4(5) (2015) PMID 25979902 PMCID PMC4599410

    Physical activity data are collected automatically by implantable cardioverter-defibrillators (ICDs). Though these data potentially provide a quantifiable and easily accessible measure of functional status, its relationship with survival has not been well studied. Patients enrolled in the Boston...
  5. Comparison of methods for analyzing left-censored occupational exposure data.

    Annals of Occupational Hygiene 58(9):1126 (2014) PMID 25261453 PMCID PMC4271092

    The National Institute for Environmental Health Sciences (NIEHS) is conducting an epidemiologic study (GuLF STUDY) to investigate the health of the workers and volunteers who participated from April to December of 2010 in the response and cleanup of the oil release after the Deepwater Horizon ex...
  6. Activation of a TRP-like channel and intracellular Ca2+ dynamics during phospholipase-C-mediated cell death.

    Journal of Cell Science 127(Pt 17):3817 (2014) PMID 25037570 PMCID PMC4150065

    The model organism Neurospora crassa undergoes programmed cell death when exposed to staurosporine. Here, we show that staurosporine causes defined changes in cytosolic free Ca(2+) ([Ca(2+)]c) dynamics and a distinct Ca(2+) signature that involves Ca(2+) influx from the external medium and inter...
  7. 0300 The NIEHS GuLF STUDY: A comparison of the β-substitution method and a Bayesian approach for handling highly censored measurement data.

    Occupational and Environmental Medicine 71 Suppl 1:A104 (2014) PMID 25018180

    Over 150 000 measurements taken on workers responding to the 2010 Deepwater Horizon oil spill are being used to develop exposure estimates for the participants in the GuLF STUDY. A large portion of the measurements, however, has values below the limit of detection (left-censored). The β-substitu...
  8. Quality evaluation of digital fundus images through combined measures.

    Journal of medical imaging (Bellingham, Wash.) 1(1):014001 (2014) PMID 26158021 PMCID PMC4478779

    The evaluation of image quality is an important step before an automatic analysis of retinal images. Several conditions can impair the acquisition of a good image, and minimum image quality requirements should be present to ensure that an automatic or semiautomatic system provides an accurate di...
  9. Using a multi-agent system approach for microaneurysm detection in fundus images

    Artificial Intelligence in Medicine 60(3):179 (2014) PMID 24423809

    Objective Microaneurysms represent the first sign of diabetic retinopathy, and their detection is fundamental for the prevention of vision impairment. Despite several research attempts to develop an automated system to detect microaneurysms in fundus images, none has shown th...
  10. A networked platform for agricultural management systems

    Computers and Electronics in Agriculture 31(1):75 (2001)

    Greenhouse control computers are an essential part of modern greenhouse operation. Climate, irrigation and nutrient supply must be controlled, in an economical way, to produce the best crop conditions. Current research on CO 2 enrichment and optimal growth strategies implies the use o...