1. Mediators of neutrophil function in children with protracted bacterial bronchitis.

    Chest 146(4):1013 (2014) PMID 24874501

    Protracted bacterial bronchitis (PBB) is a common and treatable cause of chronic wet cough in children in which the mechanisms are not understood. This study investigates the IL-1 pathway and a neutrophil gene expression signature in PBB. BAL was collected from children in an experimental cohort...
  2. Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy.

    Pediatric Pulmonology 49(9):852 (2014) PMID 24166889

    Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic...
  3. Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.

    Epigenetics 9(9):1302 (2014) PMID 25147914 PMCID PMC4169022

    Epigenetic changes including DNA methylation caused by environmental exposures may contribute to the heterogeneous inflammatory response in asthma. Here we investigate alterations in DNA methylation of purified blood monocytes that are associated with inflammatory phenotypes of asthma. Periphera...
  4. Systemic Inflammation in Older Adults With Asthma-COPD Overlap Syndrome.

    Allergy, Asthma & Immunology Research 6(4):316 (2014) PMID 24991455 PMCID PMC4077958

    The role of systemic inflammation on asthma-COPD overlap syndrome is unknown. This study aimed to examine systemic inflammation in asthma-COPD overlap syndrome, and to identify associations between clinical characteristics and inflammatory mediators in asthma-COPD overlap syndrome. In 108 adults...
  5. Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes.

    Journal of Allergy and Clinical Immunology 133(4):997 (2014) PMID 24582314

    Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms. This study aimed to identify and validate a sputum gene expression signature that discriminates asthma inflammatory phenotypes. An asthma phenotype biomarker discovery study generated gen...
  6. Sputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypes

    Journal of Allergy and Clinical Immunology 133(4):997 (2014)

    Background Airway inflammation is associated with asthma exacerbation risk, treatment response, and disease mechanisms.
  7. Elevated expression of the NLRP3 inflammasome in neutrophilic asthma.

    European Respiratory Journal 43(4):1067 (2014) PMID 24136334

    Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of active IL-1β requires proteolytic cleavage typically mediated through the formation of a caspase-1-containing inf...
  8. Elevated expression of the NLRP3 inflammasome in neutrophilic asthma.

    European Respiratory Journal 43(4):1067 (2014) PMID 24136334

    Asthma is a heterogeneous inflammatory airways disorder where interleukin (IL)-1β is thought to be a key mediator, especially in the neutrophilic subtype of asthma. The generation of active IL-1β requires proteolytic cleavage typically mediated through the formation of a caspase-1-containing inf...
  9. Neutrophilic asthma is characterised by increased rhinosinusitis with sleep disturbance and GERD.

    Asian Pacific Journal of Allergy & Immunology 32(1):66 (2014) PMID 24641293

    Asthma is a heterogeneous inflammatory disease and eosinophilic, non-eosinophilic and neutrophilic forms are recognised. While clinically similar to eosinophilic asthma, patients with non-eosinophilic asthma have different responses to treatment and little is known about the triggers of symptoms...
  10. Mechanisms of cough.

    Current Opinion in Allergy and Clinical Immunology 14(1):55 (2014) PMID 24345788

    To review recent developments in the mechanisms of chronic cough. Although cough prevalence is similar across the world, there are significant regional differences in the diseases associated with cough. This may represent regional differences in diet, environmental exposure, and diagnostic asses...
  11. Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma.

    Respirology 19(2):280 (2014) PMID 24372772

    The non-eosinophilic phenotype of asthma (NEA) is associated with chronic airway inflammation and airway neutrophilia. An accumulation of apoptotic airway epithelial cells, if not efficiently cleared by efferocytosis, can undergo secondary necrosis, with the potential for inflammation of surroun...
  12. Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome.

    Respiration 87(1):63 (2014) PMID 24029561

    The progression of obstructive airway diseases (OADs) including asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome in older adults is not well understood. To examine the prognosis of OADs and to identify potential determinants for longitudinal changes in clinic...
  13. The effect of azithromycin in adults with stable neutrophilic COPD: a double blind randomised, placebo controlled trial.

    PLoS ONE 9(8):e105609 (2014) PMID 25148049 PMCID PMC4141795

    Chronic Obstructive Pulmonary Disease (COPD) is a progressive airway disease characterised by neutrophilic airway inflammation or bronchitis. Neutrophilic bronchitis is associated with both bacterial colonisation and lung function decline and is common in exacerbations of COPD. Despite current a...
  14. Older peoples' perception of tests used in the assessment and management of COPD and asthma.

    The Clinical Respiratory Journal 7(4):367 (2013) PMID 23509896

    Outcome assessment is an important part of the management of airways disease, yet older adults may have difficulty with the burden of testing. This study evaluated the patient perception of tests used for the assessment of airways disease in older people. Older adults (>55 years) with obstructiv...
  15. Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics.

    Respirology 18(5):857 (2013) PMID 23490307

    Increased sputum neutrophilia has been observed in asthma, but also during normal ageing in asthmatics and non-asthmatics. It remains unclear what constitutes 'normal' neutrophil levels in different age groups. We assessed the relationship between age and airway neutrophils of 194 asthmatics and...
  16. Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice.

    Journal of Allergy and Clinical Immunology 131(5):1331 (2013) PMID 23561801

    Respiratory tract viruses are a major environmental risk factor for both the inception and exacerbations of asthma. Genetic defects in Toll-like receptor (TLR) 7-mediated signaling, impaired type I interferon responses, or both have been reported in asthmatic patients, although their contributio...
  17. Toll-like receptor 7 gene deficiency and early-lifePneumovirusinfection interact to predispose toward the development of asthma-like pathology in mice

    Journal of Allergy and Clinical Immunology 131(5):1331 (2013)

    Background Respiratory tract viruses are a major environmental risk factor for both the inception and exacerbations of asthma. Genetic defects in Toll-like receptor (TLR) 7–mediated signaling, impaired type I interferon responses, or both have been reported in asthmatic patie...
  18. Galectin-3: its role in asthma and potential as an anti-inflammatory target.

    Respiratory Research 14:136 (2013) PMID 24313993 PMCID PMC3878924

    Galectins constitute an evolutionary conserved family that bind to β-galactosides. Increasing evidence shows that galectins are involved in many fundamental biological processes such as cellular communication, inflammation, differentiation and apoptosis. Changes in galectin-3 (Gal-3) expression ...
  19. Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD.

    Mediators of Inflammation 2013:462934 (2013) PMID 23606791 PMCID PMC3628212

    Chronic obstructive pulmonary disease (COPD) is a common and serious respiratory disease, particularly in older individuals, characterised by fixed airway obstruction and persistent airway neutrophilia. The mechanisms that lead to these features are not well established. We investigated the cont...
  20. Combined Haemophilus influenzae respiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma.

    Thorax 67(7):588 (2012) PMID 22387445

    20-30% of patients with asthma have neutrophilic airway inflammation and reduced responsiveness to steroid therapy. They often have chronic airway bacterial colonisation and Haemophilus influenzae is one of the most commonly isolated bacteria. The relationship between chronic airway colonisation...