1. CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection.

    Journal of Immunology 194(10):4924 (2015) PMID 25847975 PMCID PMC4417644

    Rhinovirus (RV) infections are common and have the potential to exacerbate asthma. We have determined the lung transcriptome in RV strain 1B-infected naive BALB/c mice (nonallergic) and identified CCL7 and IFN regulatory factor (IRF)-7 among the most upregulated mRNA transcripts in the lung. To ...
  2. Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.

    PLoS Pathogens 11(4):e1004549 (2015) PMID 25894560 PMCID PMC4404141

    Pathogenic bacterial infections of the lung are life threatening and underpin chronic lung diseases. Current treatments are often ineffective potentially due to increasing antibiotic resistance and impairment of innate immunity by disease processes and steroid therapy. Manipulation miRNA directl...
  3. MicroRNA Function in Mast Cell Biology: Protocols to Characterize and Modulate MicroRNA Expression.

    Methods in Molecular Biology 1220:287 (2015) PMID 25388258

    MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of ...
  4. Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites.

    Nature Communications 6:7320 (2015) PMID 26102221

    Asthma is prevalent in Western countries, and recent explanations have evoked the actions of the gut microbiota. Here we show that feeding mice a high-fibre diet yields a distinctive gut microbiota, which increases the levels of the short-chain fatty acid, acetate. High-fibre or acetate-feeding ...
  5. MicroRNA function in mast cell biology: protocols to characterize and modulate microRNA expression.

    Methods in Molecular Biology 1220:287 (2015) PMID 25388258

    MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of ...
  6. Ventilation inhomogeneities in children with congenital thoracic malformations.

    BMC Pulmonary Medicine 15:25 (2015) PMID 25887144 PMCID PMC4417263

    Congenital thoracic malformations (CTM) are rare lung lesions that are managed with surgical resection or active surveillance. The objective of this study was to comprehensively assess large and small airway function in children with CTM who underwent lobectomy in early life. We hypothesise that...
  7. Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration.

    Respiratory Research 16(1):42 (2015) PMID 25889951 PMCID PMC4389443

    The persistent influx of neutrophils into the lung and subsequent tissue damage are characteristics of COPD, cystic fibrosis and acute lung inflammation. VAP-1/SSAO is an endothelial bound adhesion molecule with amine oxidase activity that is reported to be involved in neutrophil egress from the...
  8. MicroRNA function in mast cell biology: protocols to characterize and modulate microRNA expression.

    Methods in Molecular Biology 1220:287 (2015) PMID 25388258

    MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of ...
  9. Dedicated paediatric teaching remains critical to the undergraduate medical curriculum.

    Journal of Paediatrics and Child Health 50(12):949 (2014) PMID 25392980

  10. MicroRNA: potential biomarkers and therapeutic targets for allergic asthma?

    Annals of Medicine 46(8):633 (2014) PMID 25307360

    MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, ...
  11. Pulmonary immunity during respiratory infections in early life and the development of severe asthma.

    Annals of the American Thoracic Society 11 Suppl 5:S297 (2014) PMID 25525736

    Asthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR) to normally innocuous antigens. Combination therapies wi...
  12. MicroRNA: Potential biomarkers and therapeutic targets for allergic asthma?

    Annals of Medicine 46(8):633 (2014) PMID 25307360

    Abstract MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). ...
  13. Dedicated paediatric teaching remains critical to the undergraduate medical curriculum.

    Journal of Paediatrics and Child Health 50(12):949 (2014) PMID 25392980

  14. Dedicated paediatric teaching remains critical to the undergraduate medical curriculum.

    Journal of Paediatrics and Child Health 50(12):949 (2014) PMID 25392980

  15. Pulmonary Immunity during Respiratory Infections in Early Life and the Development of Severe Asthma.

    Annals of the American Thoracic Society 11 Suppl 5:S297 (2014) PMID 25525736

    Asthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR) to normally innocuous antigens. Combination therapies wi...
  16. Pulmonary immunity during respiratory infections in early life and the development of severe asthma.

    Annals of the American Thoracic Society 11 Suppl 5:S297 (2014) PMID 25525736

    Asthma affects 10% of the population in Westernized countries, being most common in children. It is a heterogeneous condition characterized by chronic allergic airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR) to normally innocuous antigens. Combination therapies wi...
  17. MicroRNA: potential biomarkers and therapeutic targets for allergic asthma?

    Annals of Medicine 46(8):633 (2014) PMID 25307360

    MicroRNAs are small non-coding RNAs that bind to multiple target mRNAs to control gene expression post-transcriptionally by inhibiting translation. In mammalian cells, microRNAs play important roles in a diverse array of cellular processes (e.g. cell proliferation and differentiation). However, ...
  18. The early origins of COPD in severe asthma: the one thing that leads to another or the two things that come together?

    Thorax 69(9):789 (2014) PMID 24813191

  19. Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy.

    Pediatric Pulmonology 49(9):852 (2014) PMID 24166889

    Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic...
  20. Differential DNA methylation profiles of infants exposed to maternal asthma during pregnancy.

    Pediatric Pulmonology 49(9):852 (2014) PMID 24166889

    Asthma is a complex disease that involves both genetic factors and environmental exposures. Aberrant epigenetic modifications, such as DNA methylation, may be important in asthma development. Fetal exposure to maternal asthma during critical periods of in utero development may lead to epigenetic...