1. Pediatric Liver Transplant Center Volume and the Likelihood of Transplantation.

    Pediatrics 136(1):e99 (2015) PMID 26077479

    Low case volume has been associated with poorer surgical outcomes in a multitude of surgical procedures. We studied the association among low case volume, outcomes, and the likelihood of pediatric liver transplantation. We studied a cohort of 6628 candidates listed in the Organ Procurement and T...
  2. Focal nodular hyperplasia in children: An institutional experience with review of the literature

    Journal of Pediatric Surgery 50(3):382 (2015)

    Background Focal nodular hyperplasia (FNH) is uncommonly diagnosed in pediatric patients and may be difficult to distinguish from a malignancy. We present a review of all children with a tissue diagnosis of FNH at our institution, describe the diagnostic modalities, and provi...
  3. Focal nodular hyperplasia in children: An institutional experience with review of the literature.

    Journal of Pediatric Surgery 50(3):382 (2015) PMID 25746693

    Focal nodular hyperplasia (FNH) is uncommonly diagnosed in pediatric patients and may be difficult to distinguish from a malignancy. We present a review of all children with a tissue diagnosis of FNH at our institution, describe the diagnostic modalities, and provide recommendations for diagnosi...
  4. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.

    Nature Communications 6:7339 (2015) PMID 26081744

    Diseases of lipid metabolism are a major cause of human morbidity, but no animal model entirely recapitulates human lipoprotein metabolism. Here we develop a xenograft mouse model using hepatocytes from a patient with familial hypercholesterolaemia caused by loss-of-function mutations in the low...
  5. Role of liver transplantation in the management of hepatoblastoma in the pediatric population.

    World journal of transplantation 4(4):294 (2014) PMID 25540737 PMCID PMC4274598

    Hepatoblastoma (HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB (unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplant...
  6. Role of liver transplantation in the management of hepatoblastoma in the pediatric population.

    World journal of transplantation 4(4):294 (2014) PMID 25540737 PMCID PMC4274598

    Hepatoblastoma (HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB (unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplant...
  7. Role of liver transplantation in the management of hepatoblastoma in the pediatric population.

    World journal of transplantation 4(4):294 (2014) PMID 25540737

    Hepatoblastoma (HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB (unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplant...
  8. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

    Nature Genetics 46(12):1267 (2014) PMID 25362482

    Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection ...
  9. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

    Nature Genetics 46(12):1267 (2014) PMID 25362482

    Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection ...
  10. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

    Nature Genetics 46(12):1267 (2014) PMID 25362482

    Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection ...
  11. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.

    Nature Genetics 46(12):1267 (2014) PMID 25362482

    Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection ...
  12. Current techniques for pediatric liver transplantation.

    Current Opinion in Organ Transplantation 19(5):468 (2014) PMID 25186822

    Orthotopic liver transplantation in the pediatric population is a technically challenging undertaking, requiring highly specialized surgical techniques unique to this group. This review describes the most current method of transplantation for these patients. Pediatric liver transplantation emplo...
  13. Current techniques for pediatric liver transplantation.

    Current Opinion in Organ Transplantation 19(5):468 (2014) PMID 25186822

    Orthotopic liver transplantation in the pediatric population is a technically challenging undertaking, requiring highly specialized surgical techniques unique to this group. This review describes the most current method of transplantation for these patients. Pediatric liver transplantation emplo...
  14. Beyond the Pediatric end-stage liver disease system: solutions for infants with biliary atresia requiring liver transplant.

    World Journal of Gastroenterology 20(32):11062 (2014) PMID 25170195 PMCID PMC4145749

    Biliary atresia (BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant...
  15. Beyond the Pediatric end-stage liver disease system: solutions for infants with biliary atresia requiring liver transplant.

    World Journal of Gastroenterology 20(32):11062 (2014) PMID 25170195 PMCID PMC4145749

    Biliary atresia (BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant...
  16. Hepatitis C in the pediatric population: transmission, natural history, treatment and liver transplantation.

    World Journal of Gastroenterology 20(32):11281 (2014) PMID 25170212 PMCID PMC4145766

    The number of children affected by the hepatitis C virus (HCV) in the United States is estimated to be between 23000 to 46000. The projected medical cost for children with HCV in the United States is $199-366 million over the next decade. The implementation of routine screening of blood supply h...
  17. Hepatitis C in the pediatric population: transmission, natural history, treatment and liver transplantation.

    World Journal of Gastroenterology 20(32):11281 (2014) PMID 25170212 PMCID PMC4145766

    The number of children affected by the hepatitis C virus (HCV) in the United States is estimated to be between 23000 to 46000. The projected medical cost for children with HCV in the United States is $199-366 million over the next decade. The implementation of routine screening of blood supply h...
  18. Long-term follow-up of portopulmonary hypertension patients after liver transplantation.

    Liver Transplantation and Surgery 20(6):724 (2014) PMID 24648168

    Portopulmonary hypertension (POPH) occurs in 5.3% to 8.5% of patients with advanced liver disease. The rate of survival in the absence of orthotopic liver transplantation (OLT) is reportedly 38% at 3 years and 28% at 5 years. Moderate to severe POPH [mean pulmonary artery pressure (MPAP) ≥ 35 mm...
  19. Long-term follow-up of portopulmonary hypertension patients after liver transplantation.

    Liver Transplantation and Surgery 20(6):724 (2014) PMID 24648168

    Portopulmonary hypertension (POPH) occurs in 5.3% to 8.5% of patients with advanced liver disease. The rate of survival in the absence of orthotopic liver transplantation (OLT) is reportedly 38% at 3 years and 28% at 5 years. Moderate to severe POPH [mean pulmonary artery pressure (MPAP) ≥ 35 mm...
  20. Long-term follow-up of portopulmonary hypertension patients after liver transplantation.

    Liver Transplantation and Surgery 20(6):724 (2014) PMID 24648168

    Portopulmonary hypertension (POPH) occurs in 5.3% to 8.5% of patients with advanced liver disease. The rate of survival in the absence of orthotopic liver transplantation (OLT) is reportedly 38% at 3 years and 28% at 5 years. Moderate to severe POPH [mean pulmonary artery pressure (MPAP) ≥ 35 mm...