Veterans Administration Liver Transplant Programs Perform as Well as Their Affiliated Academic Institutions.
Annals of Surgery 264(2):239 (2016)
Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.
Journal of Hepatology 65(2):325 (2016)
Pediatric liver cancer is a rare but serious disease whose incidence is rising, and for which the therapeutic options are limited. Development of more targeted, less toxic therapies is hindered by the lack of an experimental animal model that captures the heterogeneity and metastatic capability ...
Undifferentiated Embryonal Sarcoma of the Liver (UESL): A Single-Center Experience and Review of the Literature.
Journal of Pediatric Hematology/Oncology 38(4):261 (2016)
Undifferentiated embryonal sarcoma of the liver (UESL) is a rare and aggressive pediatric malignancy. The purpose of this study was to review the clinical, radiologic, and pathologic features and outcome of children with UESL at our institution, in the United Network of Organ Sharing database an...
Pediatric Liver Transplantation Across the ABO Blood Group Barrier: Is It an Obstacle in the Modern Era?
Journal of the American College of Surgeons 222(4):681 (2016)
The initial experience with ABO incompatible (ABOi) orthotopic liver transplantations (OLTs) was dismal. In the current study, we investigated whether ABOi pediatric OLTs could achieve acceptable patient outcomes. The option for ABOi transplantation is vital because critically ill children have ...
P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients.
Oncotarget 6(38):41162 (2015)
P2 purinergic receptors are overexpressed in certain cancer tissues, but the pathophysiologic relevance of purinergic signaling in hepatocellular carcinoma (HCC) remains unknown. To examine the role of P2 purinergic signaling in the pathogenesis of HCC and characterize extracellular nucleotide e...
Intraoperative ultrasound for liver tumor resection in children.
Journal of Surgical Research 198(2):418 (2015)
Primary hepatic neoplasms in children are rare tumors. All malignant and medically refractive benign primary pediatric liver tumors ultimately require surgical resection for cure. Accurate preoperative imaging including multidetector helical computerized tomography or magnetic resonance imaging ...
Pediatric Liver Transplant Center Volume and the Likelihood of Transplantation.
Pediatrics 136(1):e99 (2015)
Low case volume has been associated with poorer surgical outcomes in a multitude of surgical procedures. We studied the association among low case volume, outcomes, and the likelihood of pediatric liver transplantation.
We studied a cohort of 6628 candidates listed in the Organ Procurement and T...
Focal nodular hyperplasia in children: an institutional experience with review of the literature.
Journal of Pediatric Surgery 50(3):382 (2015)
Focal nodular hyperplasia (FNH) is uncommonly diagnosed in pediatric patients and may be difficult to distinguish from a malignancy. We present a review of all children with a tissue diagnosis of FNH at our institution, describe the diagnostic modalities, and provide recommendations for diagnosi...
Liver Transplantation for HoFH in Children: Single Center Experience.
Congenital Heart Disease 10(6):520 (2015)
Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.
Nature Communications 6:7339 (2015)
Diseases of lipid metabolism are a major cause of human morbidity, but no animal model entirely recapitulates human lipoprotein metabolism. Here we develop a xenograft mouse model using hepatocytes from a patient with familial hypercholesterolaemia caused by loss-of-function mutations in the low...
Role of liver transplantation in the management of hepatoblastoma in the pediatric population.
World journal of transplantation 4(4):294 (2014)
Hepatoblastoma (HB) is the most common primary liver tumor in children and accounts for two-thirds of all malignant liver neoplasms in the pediatric population. For patients with advanced HB (unresectable or unresponsive to chemotherapy), combined treatment with chemotherapy and liver transplant...
Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.
Nature Genetics 46(12):1267 (2014)
Diverse epidemiological factors are associated with hepatocellular carcinoma (HCC) prevalence in different populations. However, the global landscape of the genetic changes in HCC genomes underpinning different epidemiological and ancestral backgrounds still remains uncharted. Here a collection ...
Current techniques for pediatric liver transplantation.
Current Opinion in Organ Transplantation 19(5):468 (2014)
Orthotopic liver transplantation in the pediatric population is a technically challenging undertaking, requiring highly specialized surgical techniques unique to this group. This review describes the most current method of transplantation for these patients.
Pediatric liver transplantation emplo...
Hepatitis C in the pediatric population: transmission, natural history, treatment and liver transplantation.
World Journal of Gastroenterology 20(32):11281 (2014)
The number of children affected by the hepatitis C virus (HCV) in the United States is estimated to be between 23000 to 46000. The projected medical cost for children with HCV in the United States is $199-366 million over the next decade. The implementation of routine screening of blood supply h...
Beyond the Pediatric end-stage liver disease system: solutions for infants with biliary atresia requiring liver transplant.
World Journal of Gastroenterology 20(32):11062 (2014)
Biliary atresia (BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant...
Long-term follow-up of portopulmonary hypertension patients after liver transplantation.
Liver Transplantation and Surgery 20(6):724 (2014)
Portopulmonary hypertension (POPH) occurs in 5.3% to 8.5% of patients with advanced liver disease. The rate of survival in the absence of orthotopic liver transplantation (OLT) is reportedly 38% at 3 years and 28% at 5 years. Moderate to severe POPH [mean pulmonary artery pressure (MPAP) ≥ 35 mm...
Liver transplant fellowship and resident training is not a part of the "July effect".
Journal of Surgical Research 182(1):1 (2013)
The influx of new resident physicians has been shown to cause increased complications in academic institutions, named the "July effect." This study investigated if this effect is associated with liver transplants and if it affects patient or allograft outcomes after orthotopic liver transplantat...
Liver transplantation in cystic fibrosis: a report from Baylor College of Medicine and the Texas Children's Hospital.
Pediatric Transplantation 17(3):271 (2013)
CF affects one of 2000 Caucasians, and approximately 25% are found to have CFLD for which OLT may be indicated. Timing of transplantation, contraindications, and survival are still widely debated. We report the outcomes of OLT for pediatric patients with CFLD from the largest children's hospital...
Liver transplantation with donation after cardiac death donors: a comprehensive update.
Journal of Surgical Research 178(1):502 (2012)
Use of donation after cardiac death (DCD) donors has been proposed as an effective way to expand the availability of hepatic allografts used in orthotopic liver transplantation (OLT); yet, there remains no consensus in the medical literature as to how to choose optimal recipients and donors base...
Transplanting whole livers from donors less than 6 kilograms--is it prudent?
Journal of Surgical Research 177(2):348 (2012)
Experience suggests transplanting whole liver allografts (WL) from donors weighing <6 kg portends a worse prognosis. Patient and allograft survivals of infants who underwent transplantation with livers from donors ≥6 kg, <6 kg, or technical variant allografts from deceased donors (TV) and those ...