1. Differential use of autophagy by primary dendritic cells specialized in cross-presentation.

    Autophagy 11(6):906 (2015) PMID 25950899 PMCID PMC4502655

    Antigen-presenting cells survey their environment and present captured antigens bound to major histocompatibility complex (MHC) molecules. Formation of MHC-antigen complexes occurs in specialized compartments where multiple protein trafficking routes, still incompletely understood, converge. Aut...
  2. Modulation of antigen presentation by intracellular trafficking

    Current Opinion in Immunology 34:16 (2015)

    • Antigen must access specialised compartments for MHC I and/or MHC II presentation. • Antigen receptor targeting provides insight into trafficking routes for MHC ...
  3. Modulation of antigen presentation by intracellular trafficking

    Current Opinion in Immunology 34:16 (2015)

    • Antigen must access specialised compartments for MHC I and/or MHC II presentation. • Antigen receptor targeting provides insight into trafficking routes for MHC ...
  4. Modulation of antigen presentation by intracellular trafficking

    Current Opinion in Immunology 34:16 (2015)

    • Antigen must access specialised compartments for MHC I and/or MHC II presentation. • Antigen receptor targeting provides insight into trafficking routes for MHC ...
  5. Modulation of antigen presentation by intracellular trafficking.

    Current Opinion in Immunology 34:16 (2015) PMID 25578446

    Processing and loading of antigen into major histocompatibility complex molecules (MHC) occurs in specific intracellular compartments. Accessing MHC loading compartments requires trafficking via specific pathways, some of which have yet to be fully characterized. For MHC I, cross-presentation in...
  6. MR1 presentation of vitamin B-based metabolite ligands.

    Current Opinion in Immunology 34:28 (2015) PMID 25603223

    The major histocompatibility complex class I-related molecule MR1 can bind a novel class of antigens, namely a family of related small organic vitamin B metabolites. When bound to MR1 these metabolites are presented to a population of innate-like T cells, mucosal-associated invariant T (MAIT) ce...
  7. Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

    Journal of Immunology 194(6):2696 (2015) PMID 25653426

    Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameter...
  8. Criteria for dendritic cell receptor selection for efficient antibody-targeted vaccination.

    Journal of Immunology 194(6):2696 (2015) PMID 25653426

    Ab-targeted vaccination involves targeting a receptor of choice expressed by dendritic cells (DCs) with Ag-coupled Abs. Currently, there is little consensus as to which criteria determine receptor selection to ensure superior Ag presentation and immunity. In this study, we investigated parameter...
  9. Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.

    Journal of Immunology 193(8):3851 (2014) PMID 25200952

    Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules ("signal 1"), upregulate T cell costimulatory receptors ("signal 2"), and secrete "signal 3" cytokines (e.g., IL-12). Ma...
  10. Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.

    Journal of Immunology 193(8):3851 (2014) PMID 25200952

    Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules ("signal 1"), upregulate T cell costimulatory receptors ("signal 2"), and secrete "signal 3" cytokines (e.g., IL-12). Ma...
  11. Inflammation conditions mature dendritic cells to retain the capacity to present new antigens but with altered cytokine secretion function.

    Journal of Immunology 193(8):3851 (2014) PMID 25200952

    Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules ("signal 1"), upregulate T cell costimulatory receptors ("signal 2"), and secrete "signal 3" cytokines (e.g., IL-12). Ma...
  12. Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals.

    Current Opinion in Pharmacology 17:64 (2014) PMID 25128781

    Antigen presentation by dendritic cells (DC) is regulated directly by pathogen-associated or cell death-associated cues, or indirectly by immunomodulatory molecules produced during infection or tissue damage. DC modulation by direct encounter of pathogen-associated compounds has been thoroughly ...
  13. Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals.

    Current Opinion in Pharmacology 17:64 (2014) PMID 25128781

    Antigen presentation by dendritic cells (DC) is regulated directly by pathogen-associated or cell death-associated cues, or indirectly by immunomodulatory molecules produced during infection or tissue damage. DC modulation by direct encounter of pathogen-associated compounds has been thoroughly ...
  14. A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells.

    Journal of Experimental Medicine 211(8):1585 (2014) PMID 25049336 PMCID PMC4113946

    Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) α-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12 in humans), which pairs with an array of TCR β-chains. MAIT TCRs can bind folate- and riboflavin-based metabolites restricted by the major histocompatibilit...
  15. A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells.

    Journal of Experimental Medicine 211(8):1585 (2014) PMID 25049336 PMCID PMC4113946

    Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) α-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12 in humans), which pairs with an array of TCR β-chains. MAIT TCRs can bind folate- and riboflavin-based metabolites restricted by the major histocompatibilit...
  16. A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells.

    Journal of Experimental Medicine 211(8):1585 (2014) PMID 25049336 PMCID PMC4113946

    Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) α-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12 in humans), which pairs with an array of TCR β-chains. MAIT TCRs can bind folate- and riboflavin-based metabolites restricted by the major histocompatibilit...
  17. Developmental regulation of synthesis and dimerization of the amyloidogenic protease inhibitor cystatin C in the hematopoietic system.

    Journal of Biological Chemistry 289(14):9730 (2014) PMID 24570004 PMCID PMC3975020

    The cysteine protease inhibitor cystatin C is thought to be secreted by most cells and eliminated in the kidneys, so its concentration in plasma is diagnostic of kidney function. Low extracellular cystatin C is linked to pathologic protease activity in cancer, arthritis, atherosclerosis, aortic ...
  18. Developmental regulation of synthesis and dimerization of the amyloidogenic protease inhibitor cystatin C in the hematopoietic system.

    Journal of Biological Chemistry 289(14):9730 (2014) PMID 24570004 PMCID PMC3975020

    The cysteine protease inhibitor cystatin C is thought to be secreted by most cells and eliminated in the kidneys, so its concentration in plasma is diagnostic of kidney function. Low extracellular cystatin C is linked to pathologic protease activity in cancer, arthritis, atherosclerosis, aortic ...
  19. Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold.

    Journal of Immunology 191(7):3534 (2013) PMID 24018271

    Initiation of CTL responses against foreign pathogens also primes anti-self CTLs. Mechanisms of CTL inactivation inhibit anti-self CTLs to prevent tissue damage. These mechanisms are exploited by pathogens and tumors to evade the immune response, and present a major hurdle to adoptive CTL therap...
  20. Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold.

    Journal of Immunology 191(7):3534 (2013) PMID 24018271

    Initiation of CTL responses against foreign pathogens also primes anti-self CTLs. Mechanisms of CTL inactivation inhibit anti-self CTLs to prevent tissue damage. These mechanisms are exploited by pathogens and tumors to evade the immune response, and present a major hurdle to adoptive CTL therap...