Surgery is associated with ventricular enlargement as well as cognitive and functional decline.
Alzheimer's & Dementia 12(5):590 (2016)
In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ε4 (APOE ε4), and AD remains unclear.
We performed a retrospective cohort analy...
Centella asiatica modulates antioxidant and mitochondrial pathways and improves cognitive function in mice.
Journal of Ethnopharmacology 180:78 (2016)
This study investigates the cognitive enhancing effects of the plant Centella asiatica which is widely used Ayurvedic and traditional Chinese medicine.
The goal of this study was to determine the effects of a water extract of the medicinal plant Centella asiatica (CAW) on cognitive ability as we...
Precision Medicine: Clarity for the Complexity of Dementia.
The American Journal of Pathology 186(3):500 (2016)
Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades i...
The new world of retirement income security in America.
American Psychologist 71(4):321 (2016)
We have entered a new world of retirement income security in America, with older individuals more exposed to market risk and more vulnerable to financial insecurity than prior generations. This reflects an evolution that has altered the historical vision of a financially secure retirement suppor...
GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.
Movement Disorders 31(1):95 (2016)
Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.
We screened the GBA coding region for mutati...
The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease.
Alzheimer's Research & Therapy 8:25 (2016)
Apolipoprotein E (APOE) ɛ4 and low cerebrospinal fluid (CSF) amyloid-β42 (Aβ42) levels are predictors for developing Alzheimer's disease (AD). The results of several studies indicate an interaction between docosahexaenoic acid (DHA) consumption and cognitive outcomes by APOE genotype. Our object...
STX, a Novel Membrane Estrogen Receptor Ligand, Protects Against Amyloid-β Toxicity.
Journal of Alzheimer's Disease 51(2):391 (2016)
Because STX is a selective ligand for membrane estrogen receptors, it may be able to confer the beneficial effects of estrogen without eliciting the deleterious side effects associated with activation of the nuclear estrogen receptors. This study evaluates the neuroprotective properties of STX i...
Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer's disease subjects.
Acta Neuropsychiatrica 27(5):270 (2015)
We undertook a non-targeted lipidomics analysis of post-mortem cerebrospinal fluid (CSF), frontal cortex grey matter, and subjacent white matter to define potential biomarkers that distinguish cognitively intact subjects from those with incipient or established dementia. Our objective was to inc...
Alterations in mitochondrial number and function in Alzheimer's disease fibroblasts.
Metabolic Brain Disease 30(5):1275 (2015)
Mitochondrial dysfunction is observed in brains of Alzheimer's Disease patients as well as many rodent model systems including those modeling mutations in preseinilin 1 (PSEN1). The aim of our study was to characterize mitochondrial function and number in fibroblasts from AD patients with PSEN1 ...
Retirement patterns and the macroeconomy, 1992-2010: the prevalence and determinants of bridge jobs, phased retirement, and reentry among three recent cohorts of older americans.
Gerontologist 55(3):384 (2015)
Older Americans contemplating retirement today face a very different economic environment than prior cohorts did. This article examines whether the retirement patterns of older Americans have changed as a result.
Using data from 10 waves of the Health and Retirement Study (HRS), we examine the p...
Cognitive profile of LRRK2-related Parkinson's disease.
Movement Disorders 30(5):728 (2015)
Increasing evidence suggests that genetic factors play a role in the variability associated with cognitive performance in Parkinson's disease (PD). Mutations in the LRRK2 gene are the most common cause of monogenic PD; however, the cognitive profile of LRRK2-related PD is not well-characterized....
Cerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation.
Molecular & Cellular Proteomics 14(3):544 (2015)
Finding robust biomarkers for Parkinson disease (PD) is currently hampered by inherent technical limitations associated with imaging or antibody-based protein assays. To circumvent the challenges, we adapted a staged pipeline, starting from our previous proteomic profiling followed by high-throu...
Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
JAMA Neurology 72(2):209 (2015)
Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of this varia...
Extracellular RNAs: development as biomarkers of human disease.
Journal of Extracellular Vesicles 4:27495 (2015)
Ten ongoing studies designed to test the possibility that extracellular RNAs may serve as biomarkers in human disease are described. These studies, funded by the NIH Common Fund Extracellular RNA Communication Program, examine diverse extracellular body fluids, including plasma, serum, urine and...
Centella asiatica Attenuates Amyloid-β-Induced Oxidative Stress and Mitochondrial Dysfunction.
Journal of Alzheimer's Disease 45(3):933 (2015)
We previously showed that a water extract of the medicinal plant Centella asiatica (CAW) attenuates amyloid-β (Aβ)-induced cognitive deficits in vivo, and prevents Aβ-induced cytotoxicity in vitro. Yet the neuroprotective mechanism of CAW is unknown.
The goal of this study was to identify bioche...
Increased CSF E-Selectin in Clinical Alzheimer's Disease without Altered CSF Aβ42 and Tau.
Journal of Alzheimer's Disease 47(4):883 (2015)
Clinically diagnosed Alzheimer's disease (AD) is pathologically heterogeneous. In this multicenter cohort of 215 clinically diagnosed AD patients and 249 controls, E-selectin and vascular cell adhesion molecule 1 (VACM-1) were measured along with amyloid-β peptide 1-42 (Aβ42) and tau. We discove...
Targeted Lipidomics of Fontal Cortex and Plasma Diacylglycerols (DAG) in Mild Cognitive Impairment and Alzheimer's Disease: Validation of DAG Accumulation Early in the Pathophysiology of Alzheimer's Disease.
Journal of Alzheimer's Disease 48(2):537 (2015)
Previous studies have demonstrated augmented levels of diacylglycerols (DAG) in the frontal cortex and plasma of Alzheimer's disease (AD) patients. We extended these findings from non-targeted lipidomics studies to design a lipidomics platform to interrogate DAGs and monoacylglycerols (MAG) in t...
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
JAMA Neurology 71(11):1394 (2014)
Because APOE locus variants contribute to risk of late-onset Alzheimer disease (LOAD) and to differences in age at onset (AAO), it is important to know whether other established LOAD risk loci also affect AAO in affected participants.
To investigate the effects of known Alzheimer disease risk lo...
APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease.
JAMA Neurology 71(11):1405 (2014)
Cognitive impairment is a common and disabling problem in Parkinson disease (PD) that is not well understood and is difficult to treat. Identification of genetic variants that influence the rate of cognitive decline or pattern of early cognitive deficits in PD might provide a clearer understandi...
Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease.
Acta Neuropathologica 128(5):639 (2014)
Extracellular α-synuclein is important in the pathogenesis of Parkinson's disease (PD) and also as a potential biomarker when tested in the cerebrospinal fluid (CSF). The performance of blood plasma or serum α-synuclein as a biomarker has been found to be inconsistent and generally ineffective, ...