Baseline assessment of campus-wide general health status and mental health: Opportunity for tailored suicide prevention and mental health awareness programming.
Journal of American College Health 64(3):174 (2016)
A campus-wide assessment examined the physical and mental health status of a midsize midwestern public university.
Two thousand and forty-nine students, faculty, and staff on a single college campus were assessed in March-April 2013.
Participants completed an online survey with sections devoted ...
'Public enemy no. 1': Tobacco industry funding for the AIDS response.
Sahara Journal of Social Aspects of HIV/AIDS 13(1):41 (2016)
This article analyzes the history of tobacco industry funding for the AIDS response - a largely ignored aspect of private donor involvement. Primary documents from the Legacy Tobacco Documents Library and AIDS organizations are analyzed, alongside existing literature on the tobacco control and A...
Civil society: the catalyst for ensuring health in the age of sustainable development.
Globalization and Health 12(1):40 (2016)
Sustainable Development Goal Three is rightly ambitious, but achieving it will require doing global health differently. Among other things, progressive civil society organisations will need to be recognised and supported as vital partners in achieving the necessary transformations. We argue, usi...
Developing the PTSD Checklist-I/F for the DSM-IV (PCL-I/F): Assessing PTSD Symptom Frequency and Intensity in a Pilot Study of Male Veterans with Combat-Related PTSD.
Behavioral Sciences 5(1):59 (2015)
The widely used posttraumatic stress disorder (PTSD) Checklist (PCL) has established reliability and validity, but it does not differentiate posttraumatic symptom frequency from intensity as elements of posttraumatic symptom severity. Thus, the PCL in its existing form may not provide a comprehe...
Comparative genomics reveals insights into avian genome evolution and adaptation.
Science 346(6215):1311 (2014)
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size,...
Impact of newly adopted guidelines for management of children with isolated skull fracture.
Journal of Pediatric Surgery 49(12):1856 (2014)
In an effort to standardize practices and reduce unnecessary hospital resource utilization, we implemented guidelines for management of patients with isolated skull fractures (ISF). We sought to examine the impact of these guidelines.
Patients with nondisplaced/depressed fracture of the skull va...
Phase 2 trial of everolimus and carboplatin combination in patients with triple negative metastatic breast cancer.
Breast Cancer Research (Online Edition) 16(2):R32 (2014)
Rapamycin acts synergistically with platinum agents to induce apoptosis and inhibit proliferation in breast cancer cell lines. Combination of everolimus also known as RAD001 (oral mammalian target of rapamycin (mTOR) inhibitor) and carboplatin may have activity in metastatic triple-negative brea...
Interfering with the reconsolidation of traumatic memory: sirolimus as a novel agent for treating veterans with posttraumatic stress disorder.
Development of novel treatment approaches for combat-related posttraumatic stress disorder (PTSD) is critical, given the increasing prevalence of PTSD in veterans returning from war zone deployment. Established preclinical research using protein synthesis inhibitors (such as sirolimus) to interf...
A link between premenopausal iron deficiency and breast cancer malignancy.
BMC Cancer 13:307 (2013)
Young breast cancer (BC) patients less than 45 years old are at higher risk of dying from the disease when compared to their older counterparts. However, specific risk factors leading to this poorer outcome have not been identified.
One candidate is iron deficiency, as this is common in young wo...
Process and outcomes of patient-centered medical care with Alaska Native people at Southcentral Foundation.
Annals of Family Medicine 11 Suppl 1:S41 (2013)
This study describes key elements of the transition to a patient-centered medical home (PCMH) model at Southcentral Foundation (SCF), a tribally owned and managed primary care system, and evaluates changes in emergency care use for any reason, for asthma, and for unintentional injuries, during a...
A pilot study of letrozole for one year in women at enhanced risk of developing breast cancer: effects on mammographic density.
Anticancer Research 32(4):1327 (2012)
Tamoxifen or raloxifen for 5 years reduces the risk of developing invasive breast cancer by 40%. To address safety concerns and seek enhanced efficacy, studies of new chemopreventive agents using mammographic density as a surrogate end point are attractive.
Postmenopausal women with risk factors...
Configuration of a high-content imaging platform for hit identification and pharmacological assessment of JMJD3 demethylase enzyme inhibitors.
Journal of Biomolecular Screening 17(1):108 (2012)
The biological complexity associated with the regulation of histone demethylases makes it desirable to configure a cellular mechanistic assay format that simultaneously encompasses as many of the relevant cellular processes as possible. In this report, the authors describe the configuration of a...
Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer.
Free Radical Biology and Medicine 50(7):841 (2011)
Estrogen alone cannot explain the differences in breast cancer (BC) recurrence and incidence rates in pre- and postmenopausal women. In this study, we have tested a hypothesis that, in addition to estrogen, both iron deficiency due to menstruation and iron accumulation as a result of menstrual s...
Phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium.
PLoS ONE 6(6):e21542 (2011)
Human myometrium develops phasic contractions during labor. Phosphorylation of caldesmon (h-CaD) and extracellular signal-regulated kinase 1/2 (ERK 1/2) has been implicated in development of these contractions, however the phospho-regulation of these proteins is yet to be examined during periods...
Neuroendocrine carcinoma presenting as cardiac tamponade and dramatic response to steroids.
BMJ Case Reports 2011 (2011)
A healthy young man presented with cardiac tamponade. He underwent pericardial window and biopsy revealed chronic inflammation. Two years later, he presented with respiratory failure. CT of the thorax revealed prominent anterior mediastinal mass abutting the brachiocephalic vein consistent with ...
Why HIV/AIDS should be treated as exceptional: arguments from sub-Saharan Africa and Eastern Europe.
African Journal of AIDS Research 10 Suppl 1:345 (2011)
The idea that HIV and AIDS gets too much attention and funding emerged in 2008 with a call to end 'AIDS exceptionalism.' This article outlines a short history of AIDS exceptionalism - the idea that HIV and AIDS require a response above and beyond 'normal' health interventions and is privileged i...
Differences in cigarette and smokeless tobacco use among American Indian and Alaska Native people living in Alaska and the Southwest United States.
Nicotine & Tobacco Research 12(7):791 (2010)
This study analyzed self-reported tobacco use among American Indian and Alaska Native (AI/AN) people enrolled in the Education and Research Towards Health Study in Alaska (n = 3,821) and the Southwest United States (n = 7,505) from 2004 to 2006.
Participants (7,060 women and 4,266 men) completed...
Human uterine wall tension trajectories and the onset of parturition.
PLoS ONE 5(6):e11037 (2010)
Uterine wall tension is thought to be an important determinant of the onset of labor in pregnant women. We characterize human uterine wall tension using ultrasound from the second trimester of pregnancy until parturition and compare preterm, term and twin pregnancies. A total of 320 pregnant wom...
Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination.
Journal of the American Society for Mass Spectr... 20(9):1652 (2009)
Ubiquitination has emerged as one of the major post-translational modifications that decide on protein fate, targeting, and regulation of protein function. Whereas the ubiquitination of proteins can be monitored with classic biochemical methods, the mapping of modified side chains proves to be c...
Exceptional epidemics: AIDS still deserves a global response.
Globalization and Health 5:15 (2009)
There has been a renewed debate over whether AIDS deserves an exceptional response. We argue that as AIDS is having differentiated impacts depending on the scale of the epidemic, and population groups impacted, and so responses must be tailored accordingly. AIDS is exceptional, but not everywher...