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  1. FMT-PCCT: hybrid fluorescence molecular tomography-x-ray phase-contrast CT imaging of mouse models.

    Medical Imaging, IEEE Transactions on 33(7):1434 (2014) PMID 24686244

    We combined herein FMT with emerging X-ray phase-contrast CT (PCCT). PCCT relies on phase shift differences in tissue to achieve soft tissue contrast superior to conventional CT. We demonstrate for the first time FMT-PCCT imaging of different animal models, where FMT and PCCT scans were performed in...
  2. Integration of metabolic databases for the reconstruction of genome-scale metabolic networks.

    BMC Systems Biology 4:114 (2010) PMID 20712863 PMCID PMC2930596

    We report a semi-automated methodology aimed at streamlining the process of metabolic network reconstruction by enabling the integration of different genome-wide databases of metabolic reactions. We present results obtained by applying this methodology to the metabolic network of the plant Arabidops...
  3. Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan.

    Journal of Biomedical Optics 17(12):126011 (2012) PMID 23208296

    We examine the improvement in imaging performance, such as axial resolution and signal localization, when employing limited-projection-angle fluorescence molecular tomography (FMT) together with x-ray computed tomography (XCT) measurements versus stand-alone FMT. For this purpose, we employed living...
  4. Deep-tissue reporter-gene imaging with fluorescence and optoacoustic tomography: a performance overview.

    Molecular Imaging & Biology 16(5):652 (2014) PMID 24609633

    We show imaging capacity that can shift the visualization paradigm in biological discovery. The results are relevant not only to reporter gene imaging, but stand as cross-platform comparison for all methods imaging near infrared fluorescent contrast agents....
  5. Limited-projection-angle hybrid fluorescence molecular tomography of multiple molecules.

    Journal of Biomedical Optics 19(4):046016 (2014) PMID 24770661

    We investigated multimoiety imaging in the context of a limited-projection-angle hybrid fluorescence molecular tomography (FMT), and x-ray computed tomography implementation and the further registration with positron emission tomography (PET) data. Multichannel FMT systems may image fluorescent prob...
  6. Cardioprotective C-kit⁺ bone marrow cells attenuate apoptosis after acute myocardial infarction in mice - in-vivo assessment with fluorescen...

    Theranostics 3(11):903 (2013) PMID 24312159 PMCID PMC3841340

    We therefore thought to examine the early course of apoptosis following myocardial infarction - in-vivo - and non-invasively determine the effect of c-kit⁺ bone marrow cells on post-MI remodeling. We studied apoptosis in wild-type Kit(+/+) , c-kit mutant Kit(W)/Kit(W-v) and Kit(W)/Kit(W-v) mice afte...