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  1. Deep-tissue reporter-gene imaging with fluorescence and optoacoustic tomography: a performance overview.

    Molecular Imaging & Biology 16(5):652 (2014) PMID 24609633

    A primary enabling feature of near-infrared fluorescent proteins (FPs) and fluorescent probes is the ability to visualize deeper in tissues than in the visible. The purpose of this work is to find which is the optimal visualization method that can exploit the advantages of this novel class of FP...
  2. FMT-PCCT: hybrid fluorescence molecular tomography-x-ray phase-contrast CT imaging of mouse models.

    Medical Imaging, IEEE Transactions on 33(7):1434 (2014) PMID 24686244

    The implementation of hybrid fluorescence molecular tomography (FMT) and X-ray computed tomography (CT) has been shown to be a necessary development, not only for combining anatomical with functional and molecular contrast, but also for generating optical images of high accuracy. FMT affords hig...
  3. Limited-projection-angle hybrid fluorescence molecular tomography of multiple molecules.

    Journal of Biomedical Optics 19(4):046016 (2014) PMID 24770661

    An advantage of fluorescence methods over other imaging modalities is the ability to concurrently resolve multiple moieties using fluorochromes emitting at different spectral regions. Simultaneous imaging of spectrally separated agents is helpful in interrogating multiple functions or establishi...
  4. Cardioprotective C-kit⁺ bone marrow cells attenuate apoptosis after acute myocardial infarction in mice - in-vivo assessment with fluorescence molecular imaging.

    Theranostics 3(11):903 (2013) PMID 24312159 PMCID PMC3841340

    Cardiomyocyte loss via apoptosis plays a crucial role in ventricular remodeling following myocardial infarction (MI). Cell-based therapy approaches using bone marrow derived c-kit⁺ pluripotent cells may attenuate apoptosis following ischemic injury. We therefore thought to examine the early cour...
  5. Improving limited-projection-angle fluorescence molecular tomography using a co-registered x-ray computed tomography scan.

    Journal of Biomedical Optics 17(12):126011 (2012) PMID 23208296

    We examine the improvement in imaging performance, such as axial resolution and signal localization, when employing limited-projection-angle fluorescence molecular tomography (FMT) together with x-ray computed tomography (XCT) measurements versus stand-alone FMT. For this purpose, we employed li...
  6. Integration of metabolic databases for the reconstruction of genome-scale metabolic networks.

    BMC Systems Biology 4:114 (2010) PMID 20712863 PMCID PMC2930596

    Genome-scale metabolic reconstructions have been recognised as a valuable tool for a variety of applications ranging from metabolic engineering to evolutionary studies. However, the reconstruction of such networks remains an arduous process requiring a high level of human intervention. This proc...