1. KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development

    Cell Stem Cell 13(6):769 (2013)

  2. Response to "Can 'humanized' mice improve drug development in the 21st century?".

    Trends in Pharmacological Sciences 34(8):425 (2013) PMID 23876405

  3. Response to “Can ‘humanized’ mice improve drug development in the 21st century?”

    Trends in Pharmacological Sciences 34(8):425 (2013)

  4. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.

    Cell Stem Cell 12(6):748 (2013) PMID 23746980 PMCID PMC3922205

    Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-der...
  5. KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development

    Cell Stem Cell 12(6):748 (2013)

    Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks ...
  6. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.

    Cell Stem Cell 12(6):748 (2013) PMID 23746980 PMCID PMC3922205

    Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-der...
  7. A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity

    Current Biology 21(1):45 (2011)

    Human embryonic stem (hES) cells show an atypical cell-cycle regulation characterized by a high proliferation rate and a short G1 phase [1,2]. In fact, a shortened G1 phase might protect ES cells from external signals inducing differentiation, as shown for certain stem cells [3]. It ha...
  8. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity.

    Current Biology 21(1):45 (2011) PMID 21167714 PMCID PMC3034649

    Human embryonic stem (hES) cells show an atypical cell-cycle regulation characterized by a high proliferation rate and a short G1 phase. In fact, a shortened G1 phase might protect ES cells from external signals inducing differentiation, as shown for certain stem cells. It has been suggested tha...
  9. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity.

    Current Biology 21(1):45 (2011) PMID 21167714 PMCID PMC3034649

    Human embryonic stem (hES) cells show an atypical cell-cycle regulation characterized by a high proliferation rate and a short G1 phase. In fact, a shortened G1 phase might protect ES cells from external signals inducing differentiation, as shown for certain stem cells. It has been suggested tha...
  10. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment.

    Journal of Clinical Investigation 120(3):924 (2010) PMID 20179355 PMCID PMC2827952

    A paucity of versatile small animal models of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection has been an impediment to both furthering understanding of virus biology and testing antiviral therapies. We recently described a regulatable system for repopulating the liver of immunodef...
  11. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model.

    PNAS 104(51):20507 (2007) PMID 18077355 PMCID PMC2154461

    We report the successful transplantation of human hepatocytes in immunodeficient, fumarylacetoacetate hydrolase-deficient (fah(-/-)) mice. Engraftment occurs over the entire liver acinus upon transplantation. A few weeks after transplantation, increasing concentrations of human proteins (e.g., h...
  12. Whole animal copper flux assessed by positron emission tomography in the Long-Evans cinnamon rat--a feasibility study.

    BioMetals 18(1):83 (2005) PMID 15865413

    Copper is an essential trace element. However, excess copper can lead to oxidation of biomolecules and cell damage and copper levels must be carefully controlled. While copper homeostasis has been studied extensively at the cellular level, short-term body copper fluxes are poorly understood. Her...
  13. Herpes simplex virus hepatitis 4 years after liver transplantation.

    Journal of Gastroenterology 38(10):1005 (2003) PMID 14614611

    If not promptly recognized and treated, herpes simplex virus (HSV) hepatitis is associated with a high mortality. A patient transplanted for primary sclerosing cholangitis required, 4 years later, a colectomy for a steroid-resistant flare of ulcerative colitis. He subsequently developed fever, w...
  14. Interaction of the CopZ Copper Chaperone with the CopA Copper ATPase ofEnterococcus hiraeAssessed by Surface Plasmon Resonance

    Biochemical and Biophysical Research Communicat... 288(1):172 (2001)

    Intracellular copper routing in Enterococcus hirae can be accomplished by the CopZ metallochaperone. Using surface plasmon resonance analysis, we show here that CopZ interacts with the CopA copper ATPase. The binding affinity of CopZ for CopA was increased in the presence of copper, du...
  15. Tetrathiomolybdate inhibition of theEnterococcus hiraeCopB copper ATPase

    FEBS Letters 507(3):367 (2001)

    Tetrathiomolybdate (TTM) avidly interacts with copper and has recently been employed to reduce excess copper in patients with Wilson disease. We found that TTM inhibits the purified Enterococcus hirae CopB copper ATPase with an IC 50 of 34 nM. Dithiomolybdate and trithiomolybda...
  16. Epidermal growth factor is decreased in liver of rats with biliary cirrhosis but does not act as paracrine growth factor immediately after hepatectomy

    Journal of Hepatology 33(2):275 (2000)

    Background/Aims: Epidermal growth factor, a potent mitogen for hepatocytes and cholangiocytes, is thought to act as an immediate-early gene after partial hepatectomy. Since regeneration is impaired in cirrhosis, we explored the expression of epidermal growth factor in cirrhotic rat l...