1. Photoautotrophic Polyhydroxybutyrate Granule Formation Is Regulated by Cyanobacterial Phasin PhaP in Synechocystis sp. Strain PCC 6803.

    Applied and Environmental Microbiology 81(13):4411 (2015) PMID 25911471 PMCID PMC4475881

    Cyanobacteria are photoautotrophic microorganisms which fix atmospheric carbon dioxide via the Calvin-Benson cycle to produce carbon backbones for primary metabolism. Fixed carbon can also be stored as intracellular glycogen, and in some cyanobacterial species like Synechocystis sp. strain PCC 6...
  2. The Bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit of acetyl-CoA carboxylase.

    Molecular Microbiology 95(6):1025 (2015) PMID 25557370

    Biosynthesis of fatty acids is one of the most fundamental biochemical pathways in nature. In bacteria and plant chloroplasts, the committed and rate-limiting step in fatty acid biosynthesis is catalyzed by a multi-subunit form of the acetyl-CoA carboxylase enzyme (ACC). This enzyme carboxylates...
  3. The bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit of acetyl-CoA carboxylase.

    Molecular Microbiology 95(6):1025 (2015) PMID 25557370

    Biosynthesis of fatty acids is one of the most fundamental biochemical pathways in nature. In bacteria and plant chloroplasts, the committed and rate-limiting step in fatty acid biosynthesis is catalyzed by a multi-subunit form of the acetyl-CoA carboxylase enzyme (ACC). This enzyme carboxylates...
  4. Nitrogen Starvation Acclimation in Synechococcus elongatus: Redox-Control and the Role of Nitrate Reduction as an Electron Sink.

    Life (2075-1729) 5(1):888 (2015) PMID 25780959 PMCID PMC4390884

    Nitrogen starvation acclimation in non-diazotrophic cyanobacteria is characterized by a process termed chlorosis, where the light harvesting pigments are degraded and the cells gradually tune down photosynthetic and metabolic activities. The chlorosis response is governed by a complex and poorly...
  5. Phosphoproteome of the cyanobacterium Synechocystis sp. PCC 6803 and its dynamics during nitrogen starvation.

    Frontiers in Microbiology 6:248 (2015) PMID 25873915 PMCID PMC4379935

    Cyanobacteria have shaped the earth's biosphere as the first oxygenic photoautotrophs and still play an important role in many ecosystems. The ability to adapt to changing environmental conditions is an essential characteristic in order to ensure survival. To this end, numerous studies have show...
  6. A widespread glutamine-sensing mechanism in the plant kingdom.

    Cell 159(5):1188 (2014) PMID 25416954

    Glutamine is the primary metabolite of nitrogen assimilation from inorganic nitrogen sources in microorganisms and plants. The ability to monitor cellular nitrogen status is pivotal for maintaining metabolic homeostasis and sustaining growth. The present study identifies a glutamine-sensing mech...
  7. A Widespread Glutamine-Sensing Mechanism in the Plant Kingdom

    Cell 159(5):1188 (2014)

    Glutamine is the primary metabolite of nitrogen assimilation from inorganic nitrogen sources in microorganisms and plants. The ability to monitor cellular nitrogen status is pivotal for maintaining metabolic homeostasis and sustaining growth. The present study identifies a glutamine-se...
  8. A widespread glutamine-sensing mechanism in the plant kingdom.

    Cell 159(5):1188 (2014) PMID 25416954

    Glutamine is the primary metabolite of nitrogen assimilation from inorganic nitrogen sources in microorganisms and plants. The ability to monitor cellular nitrogen status is pivotal for maintaining metabolic homeostasis and sustaining growth. The present study identifies a glutamine-sensing mech...
  9. A widespread glutamine-sensing mechanism in the plant kingdom.

    Cell 159(5):1188 (2014) PMID 25416954

    Glutamine is the primary metabolite of nitrogen assimilation from inorganic nitrogen sources in microorganisms and plants. The ability to monitor cellular nitrogen status is pivotal for maintaining metabolic homeostasis and sustaining growth. The present study identifies a glutamine-sensing mech...
  10. SPR analysis of promoter binding of Synechocystis PCC6803 transcription factors NtcA and CRP suggests cross-talk and sheds light on regulation by effector molecules.

    FEBS Letters 588(14):2270 (2014) PMID 24846138

    Surface plasmon resonance monitoring of the binding of transcription factors cAMP receptor protein (CRP) and nitrogen control factor of cyanobacteria (NtcA) from Synechocystis sp. PCC6803 to promoter fragments of glnA, glnN (NtcA regulon) and cccS (CRP regulon), revealed exclusive CRP binding to...
  11. SPR analysis of promoter binding of Synechocystis PCC6803 transcription factors NtcA and CRP suggests cross-talk and sheds light on regulation by effector molecules.

    FEBS Letters 588(14):2270 (2014) PMID 24846138

    Surface plasmon resonance monitoring of the binding of transcription factors cAMP receptor protein (CRP) and nitrogen control factor of cyanobacteria (NtcA) from Synechocystis sp. PCC6803 to promoter fragments of glnA, glnN (NtcA regulon) and cccS (CRP regulon), revealed exclusive CRP binding to...
  12. Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of PII protein.

    Proteins: Structure, Function and Bioinformatics 82(6):1048 (2014) PMID 24218085 PMCID PMC4282546

    PII protein is one of the largest families of signal transduction proteins in archaea, bacteria, and plants, controlling key processes of nitrogen assimilation. An intriguing characteristic for many PII proteins is that the three ligand binding sites exhibit anticooperative allosteric regulation...
  13. Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of PII protein.

    Proteins: Structure, Function and Bioinformatics 82(6):1048 (2014) PMID 24218085

    PII protein is one of the largest families of signal transduction proteins in archaea, bacteria, and plants, controlling key processes of nitrogen assimilation. An intriguing characteristic for many PII proteins is that the three ligand binding sites exhibit anticooperative allosteric regulation...
  14. Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of PII protein.

    Proteins: Structure, Function and Bioinformatics 82(6):1048 (2014) PMID 24218085

    PII protein is one of the largest families of signal transduction proteins in archaea, bacteria, and plants, controlling key processes of nitrogen assimilation. An intriguing characteristic for many PII proteins is that the three ligand binding sites exhibit anticooperative allosteric regulation...
  15. Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of PII protein.

    Proteins: Structure, Function and Bioinformatics 82(6):1048 (2014) PMID 24218085 PMCID PMC4282546

    PII protein is one of the largest families of signal transduction proteins in archaea, bacteria, and plants, controlling key processes of nitrogen assimilation. An intriguing characteristic for many PII proteins is that the three ligand binding sites exhibit anticooperative allosteric regulation...
  16. Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of PII protein.

    Proteins: Structure, Function and Bioinformatics 82(6):1048 (2014) PMID 24218085 PMCID PMC4282546

    PII protein is one of the largest families of signal transduction proteins in archaea, bacteria, and plants, controlling key processes of nitrogen assimilation. An intriguing characteristic for many PII proteins is that the three ligand binding sites exhibit anticooperative allosteric regulation...
  17. A widespread glutamine sensing mechanism in the plant kingdom

    Cell (2014)

    Glutamine is the primary metabolite of nitrogen assimilation from inorganic nitrogen sources in microorganisms and plants. The ability to monitor the cellular nitrogen status is pivotal for maintaining metabolic homeostasis and sustaining growth. The present study identifies a glutamin...
  18. A widespread glutamine sensing mechanism in the plant kingdom

    Cell (2014)

    Glutamine is the primary metabolite of nitrogen assimilation from inorganic nitrogen sources in microorganisms and plants. The ability to monitor the cellular nitrogen status is pivotal for maintaining metabolic homeostasis and sustaining growth. The present study identifies a glutamin...
  19. A widespread glutamine sensing mechanism in the plant kingdom

    Cell (2014)

    Glutamine is the primary metabolite of nitrogen assimilation from inorganic nitrogen sources in microorganisms and plants. The ability to monitor the cellular nitrogen status is pivotal for maintaining metabolic homeostasis and sustaining growth. The present study identifies a glutamin...
  20. Effects of PipX on NtcA-dependent promoters and characterization of the cox3 promoter region in the heterocyst-forming cyanobacterium Anabaena sp. PCC 7120.

    FEBS Letters 588(9):1787 (2014) PMID 24685693

    In Anabaena, the pipX gene is induced in the cells differentiating into heterocysts, being the PipX factor required for full expression of late heterocyst-specific genes. Here we show that PipX has a positive effect on in vitro binding of the transcription factor NtcA to DNA, as well as on trans...