The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape
Current Biology 25(21):2878 (2015)
The Role of Recent Admixture in Forming the Contemporary West Eurasian Genomic Landscape.
Current Biology 25(19):2518 (2015)
Over the past few years, studies of DNA isolated from human fossils and archaeological remains have generated considerable novel insight into the history of our species. Several landmark papers have described the genomes of ancient humans across West Eurasia, demonstrating the presence of large-...
Genomic structural variants are linked with intellectual disability.
Journal of Neural Transmission 122(9):1289 (2015)
Mutations in more than 500 genes have been associated with intellectual disability (ID) and related disorders of cognitive function, such as autism and schizophrenia. Here we aimed to unravel the molecular epidemiology of non-specific ID in a genetic isolate using a combination of population and...
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
Brain Imaging and Behavior 8(2):153 (2014)
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, gene...
High altitude adaptation in Daghestani populations from the Caucasus.
Humangenetik 131(3):423 (2012)
We have surveyed 15 high-altitude adaptation candidate genes for signals of positive selection in North Caucasian highlanders using targeted re-sequencing. A total of 49 unrelated Daghestani from three ethnic groups (Avars, Kubachians, and Laks) living in ancient villages located at around 2,000...
The dual origin of Tati-speakers from Dagestan as written in the genealogy of uniparental variants.
American Journal of Human Biology 24(4):391 (2012)
Tat language is classified in an Iranian subbranch of the Indo-European family. It is spoken in the Caucasus and in the West Caspian region by populations with heterogeneous cultural traditions and religion whose ancestry is unknown. The aim of this study is to get a first insight about the gene...
Crohn's disease and genetic hitchhiking at IBD5.
Molecular Biology and Evolution 29(1):101 (2012)
Inflammatory bowel disease 5 (IBD5) is a 250 kb haplotype on chromosome 5 that is associated with an increased risk of Crohn's disease in Europeans. The OCTN1 gene is centrally located on IBD5 and encodes a transporter of the antioxidant ergothioneine (ET). The 503F variant of OCTN1 is strongly ...
[Mapping genes related to early onset major depressive disorder in Dagestan genetic isolates].
Turkish Journal of Psychiatry 23(3):161 (2012)
The purpose of this study was to determine the molecular epidemiology of early onset major depressive disorder (MDD) in genetic isolates of the Caucasus Dagestan indigenous ethnic populations using molecular and statistical population-genetic approaches.
Two multigenerational pedigrees from two ...
The key role of patrilineal inheritance in shaping the genetic variation of Dagestan highlanders.
Journal of Human Genetics 54(12):689 (2009)
The Caucasus region is a complex cultural and ethnic mosaic, comprising populations that speak Caucasian, Indo-European and Altaic languages. Isolated mountain villages (auls) in Dagestan still preserve high level of genetic and cultural diversity and have patriarchal societies with a long histo...
J1-M267 Y lineage marks climate-driven pre-historical human displacements.
European Journal of Human Genetics 17(11):1520 (2009)
The present day distribution of Y chromosomes bearing the haplogroup J1 M267(*)G variant has been associated with different episodes of human demographic history, the main one being the diffusion of Islam since the Early Middle Ages. To better understand the modes and timing of J1 dispersals, we...
Fine-scaled human genetic structure revealed by SNP microarrays.
Genome Research 19(5):815 (2009)
We report an analysis of more than 240,000 loci genotyped using the Affymetrix SNP microarray in 554 individuals from 27 worldwide populations in Africa, Asia, and Europe. To provide a more extensive and complete sampling of human genetic variation, we have included caste and tribal samples from...
Culture creates genetic structure in the Caucasus: autosomal, mitochondrial, and Y-chromosomal variation in Daghestan.
BMC Genetics 9:47 (2008)
Near the junction of three major continents, the Caucasus region has been an important thoroughfare for human migration. While the Caucasus Mountains have diverted human traffic to the few lowland regions that provide a gateway from north to south between the Caspian and Black Seas, highland pop...
Evidence of still-ongoing convergence evolution of the lactase persistence T-13910 alleles in humans.
The American Journal of Human Genetics 81(3):615 (2007)
A single-nucleotide variant, C/T(-13910), located 14 kb upstream of the lactase gene (LCT), has been shown to be completely correlated with lactase persistence (LP) in northern Europeans. Here, we analyzed the background of the alleles carrying the critical variant in 1,611 DNA samples from 37 p...
Genetics and population history of Caucasus populations.
Human Biology 75(6):837 (2003)
We describe aspects of genetic diversity in several ethnic populations of the Caucasus Mountains of Daghestan using mitochondrial DNA sequences and a sample of 100 polymorphic Alu insertion loci. The mitochondrial DNA (mtDNA) sequences are like those of Europe. Principal coordinates and nearest ...