Imaging Factors That Influence Surgical Margins After Preoperative 125I Radioactive Seed Localization of Breast Lesions: Comparison With Wire Localization.
American Journal of Roentgenology 206(5):1112 (2016)
The objective of this study was to compare the potential influence of imaging variables on surgical margins after preoperative radioactive seed localization (RSL) and wire localization (WL) techniques.
A total of 565 women with 660 breast lesions underwent RSL or WL between May 16, 2012, and May...
Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers.
Nature Communications 7:12498 (2016)
Resistance to oestrogen-deprivation therapy is common in oestrogen-receptor-positive (ER+) breast cancer. To better understand the contributions of tumour heterogeneity and evolution to resistance, here we perform comprehensive genomic characterization of 22 primary tumours sampled before and af...
Leading the Way in Nursing Through SERVANT LEADERSHIP.
Imprint 63(2):30 (2016)
Radiation-Associated Undifferentiated Pleomorphic Sarcoma is Associated with Worse Clinical Outcomes than Sporadic Lesions.
Annals of Surgical Oncology 22(12):3913 (2015)
Radiation therapy is used increasingly as a component of multidisciplinary treatment for many solid tumors. One complication of such treatment is the development of radiation-associated sarcoma (RAS). Undifferentiated pleomorphic sarcoma (UPS), previously termed "malignant fibrous histiocytoma" ...
Sonography and Sonographically Guided Needle Biopsy of Internal Mammary Nodes in Staging of Patients With Breast Cancer.
American Journal of Roentgenology 205(4):905 (2015)
The purpose of this study was to identify the prevalence of occult nodal metastases on routine ultrasound examination of internal mammary (IM) nodal basins in patients with breast cancer.
Patients with primary breast cancer (n = 595) underwent breast ultrasound evaluation between September 1, 20...
Modernizing Eligibility Criteria for Molecularly Driven Trials.
Journal of Clinical Oncology 33(25):2815 (2015)
As more clinical trials of molecularly targeted agents evolve, the number of eligibility criteria seems to be increasing. The importance and utility of eligibility criteria must be considered in the context of the fundamental goal of a clinical trial: to understand the risks and benefits of a tr...
'Mini-GEMs': short, focused e-learning videos in geriatric medicine.
Clinical Medicine 15 Suppl 3:s27 (2015)
Servant Leadership: Key Principle #9--Commitment to the Growth of People.
Imprint 62(2):17 (2015)
INTERPROFESSIONAL COLLABORATION: WORKING TOGETHER TO IMPACT FUTURE OF HEALTH CARE.
Imprint 62(3):22 (2015)
Physical therapy as an adjunct treatment for people living with HIV/AIDS: an allied health perspective.
Journal of allied health 43(2):e11 (2014)
With the increased life expectancy for people living with HIV/AIDS (PLWHA) has come chronic HIV-related impairments, many of which can be successfully treated by physical therapy (PT). The purpose of this study is to determine common HIV-related impairments that merit PT, HIV providers' PT refer...
Geriatric medicine workforce planning: a giant geriatric problem or has the tide turned?
Clinical Medicine 14(2):102 (2014)
The UK's population is ageing and an adequately staffed geriatric medicine workforce is essential for high quality care. We evaluated the current and future geriatric medicine workforce, drawing on data relating to the UK population, current geriatric medicine consultants and trainees, recruitme...
USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancer.
The Cancer Journal 19(1):10 (2013)
USP-11, a member of the ubiquitin-specific protease family, has emerged as an essential regulator of double-strand break repair. Few studies have shown that silencing USP-11 led to hypersensitivity to poly(ADP-ribose) polymerase inhibition, ionizing radiation, and DNA-damaging agents. We sought ...
Announcing the surgical standards manual project: a call for volunteers.
Bulletin of the American College of Surgeons 97(9):67 (2012)
Whole-genome analysis informs breast cancer response to aromatase inhibition.
Nature 486(7403):353 (2012)
To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant aromatase inhibitor therapy by massively parallel sequencing and analysis. Eighteen signi...
Spatial and visuospatial working memory tests predict performance in classic multiple-object tracking in young adults, but nonspatial measures of the executive do not.
Attention, Perception & Psychophysics 74(2):300 (2012)
An individual-differences approach was used to investigate the roles of visuospatial working memory and the executive in multiple-object tracking. The Corsi Blocks and Visual Patterns Tests were used to assess visuospatial working memory. Two relatively nonspatial measures of the executive were ...
Fitting parametric random effects models in very large data sets with application to VHA national data.
BMC Medical Research Methodology 12:163 (2012)
With the current focus on personalized medicine, patient/subject level inference is often of key interest in translational research. As a result, random effects models (REM) are becoming popular for patient level inference. However, for very large data sets that are characterized by large sample...
Tamoxifen downregulates ets oncogene family members ETV4 and ETV5 in benign breast tissue: implications for durable risk reduction.
Cancer Prevention Research 4(11):1852 (2011)
Five years of tamoxifen reduces breast cancer risk by nearly 50% but is associated with significant side effects and toxicities. A better understanding of the direct and indirect effects of tamoxifen in benign breast tissue could elucidate new mechanisms of breast carcinogenesis, suggest novel c...
Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based intrinsic subtype--ACOSOG Z1031.
Journal of Clinical Oncology 29(17):2342 (2011)
Preoperative aromatase inhibitor (AI) treatment promotes breast-conserving surgery (BCS) for estrogen receptor (ER)-positive breast cancer. To study this treatment option, responses to three AIs were compared in a randomized phase II neoadjuvant trial designed to select agents for phase III inve...
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.
JAMA 305(18):1873 (2011)
Prediction of high probability of survival from standard cancer treatments is fundamental for individualized cancer treatment strategies.
To develop a predictor of response and survival from chemotherapy for newly diagnosed invasive breast cancer.
Prospective multicenter study conducted from Jun...
Invasive neuroendocrine carcinoma of the breast: a distinctive subtype of aggressive mammary carcinoma.
Cancer 116(19):4463 (2010)
Neuroendocrine carcinoma (NEC) of the breast, a pathologic entity newly defined in the 2003 World Health Organization classification of tumors, is a rare type of tumor that is not well recognized or studied. The purpose of this first case-controlled study is to reveal the clinicopathologic featu...