1. Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network.

    Journal of Cell Biology 208(3):331 (2015) PMID 25646088 PMCID PMC4315243

    Cell interactions with the extracellular matrix (ECM) can regulate multiple cellular activities and the matrix itself in dynamic, bidirectional processes. One such process is local proteolytic modification of the ECM. Invadopodia of tumor cells are actin-rich proteolytic protrusions that locally...
  2. Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network.

    Journal of Cell Biology 208(3):331 (2015) PMID 25646088

    Cell interactions with the extracellular matrix (ECM) can regulate multiple cellular activities and the matrix itself in dynamic, bidirectional processes. One such process is local proteolytic modification of the ECM. Invadopodia of tumor cells are actin-rich proteolytic protrusions that locally...
  3. Pathogenic prion protein fragment (PrP106–126) promotes human immunodeficiency virus type-1 infection in peripheral blood monocyte-derived macrophages

    Virology 476:372 (2015)

    Transfusion of blood and blood products contaminated with the pathogenic form of prion protein Prpsc, thought to be the causative agent of variant a Creutzfeldt–Jakob disease (vCJD), may result in serious consequences in recipients with a compromised immune system, for example, as seen...
  4. Pathogenic prion protein fragment (PrP106–126) promotes human immunodeficiency virus type-1 infection in peripheral blood monocyte-derived macrophages

    Virology 476:372 (2015)

    Transfusion of blood and blood products contaminated with the pathogenic form of prion protein Prpsc, thought to be the causative agent of variant a Creutzfeldt–Jakob disease (vCJD), may result in serious consequences in recipients with a compromised immune system, for example, as seen...
  5. Pathogenic prion protein fragment (PrP106-126) promotes human immunodeficiency virus type-1 infection in peripheral blood monocyte-derived macrophages.

    Virology 476:372 (2015) PMID 25589240

    Transfusion of blood and blood products contaminated with the pathogenic form of prion protein Prp(sc), thought to be the causative agent of variant a Creutzfeldt-Jakob disease (vCJD), may result in serious consequences in recipients with a compromised immune system, for example, as seen in HIV-...
  6. Pathogenic prion protein fragment (PrP106–126) promotes human immunodeficiency virus type-1 infection in peripheral blood monocyte-derived macrophages

    Virology 476:372 (2015)

    Transfusion of blood and blood products contaminated with the pathogenic form of prion protein Prpsc, thought to be the causative agent of variant a Creutzfeldt–Jakob disease (vCJD), may result in serious consequences in recipients with a compromised immune system, for example, as seen...
  7. Non-coding RNAs and heme oxygenase-1 in vaccinia virus infection

    Biochemical and Biophysical Research Communicat... 454(1):84 (2014)

    • Heme oxygenase-1 (HO-1) induction inhibited vaccinia virus infection of macrophages. • Reduced infectivity inversely correlated with increased expression of non-...
  8. Non-coding RNAs and heme oxygenase-1 in vaccinia virus infection.

    Biochemical and Biophysical Research Communicat... 454(1):84 (2014) PMID 25450361

    Small nuclear RNAs (snRNAs) are <200 nucleotide non-coding uridylate-rich RNAs. Although the functions of many snRNAs remain undetermined, a population of snRNAs is produced during the early phase of infection of cells by vaccinia virus. In the present study, we demonstrate a direct correlation ...
  9. Non-coding RNAs and heme oxygenase-1 in vaccinia virus infection.

    Biochemical and Biophysical Research Communicat... 454(1):84 (2014) PMID 25450361

    Small nuclear RNAs (snRNAs) are <200 nucleotide non-coding uridylate-rich RNAs. Although the functions of many snRNAs remain undetermined, a population of snRNAs is produced during the early phase of infection of cells by vaccinia virus. In the present study, we demonstrate a direct correlation ...
  10. Local and global dynamics of the basement membrane during branching morphogenesis require protease activity and actomyosin contractility.

    Developmental Biology 394(2):197 (2014) PMID 25158168 PMCID PMC4174355

    Many epithelial tissues expand rapidly during embryonic development while remaining surrounded by a basement membrane. Remodeling of the basement membrane is assumed to occur during branching morphogenesis to accommodate epithelial growth, but how such remodeling occurs is not yet clear. We repo...
  11. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.

    Nature Cell Biology 16(9):909 (2014) PMID 25150978 PMCID PMC4150836

    Rho-family GTPases govern distinct types of cell migration on different extracellular matrix proteins in tissue culture or three-dimensional (3D) matrices. We searched for mechanisms selectively regulating 3D cell migration in different matrix environments and discovered a form of Cdc42-RhoA cro...
  12. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.

    Nature Cell Biology 16(9):909 (2014) PMID 25150978 PMCID PMC4150836

    Rho-family GTPases govern distinct types of cell migration on different extracellular matrix proteins in tissue culture or three-dimensional (3D) matrices. We searched for mechanisms selectively regulating 3D cell migration in different matrix environments and discovered a form of Cdc42-RhoA cro...
  13. An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.

    Nature Cell Biology 16(9):909 (2014) PMID 25150978 PMCID PMC4150836

    Rho-family GTPases govern distinct types of cell migration on different extracellular matrix proteins in tissue culture or three-dimensional (3D) matrices. We searched for mechanisms selectively regulating 3D cell migration in different matrix environments and discovered a form of Cdc42-RhoA cro...
  14. Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix.

    Science 345(6200):1062 (2014) PMID 25170155

    Cells use actomyosin contractility to move through three-dimensional (3D) extracellular matrices. Contractility affects the type of protrusions cells use to migrate in 3D, but the mechanisms are unclear. In this work, we found that contractility generated high-pressure lobopodial protrusions in ...
  15. MYPT1 regulates contractility and microtubule acetylation to modulate integrin adhesions and matrix assembly.

    Nature Communications 5:3510 (2014) PMID 24667306 PMCID PMC4190669

    Although much is known about how individual cytoskeletal systems contribute to physiological processes such as cell migration and branching morphogenesis, little is known about how these different systems actively coordinate their functions after polymerization. Here we show that both fibroblast...
  16. Cloning and characterization of chicken α5 integrin: Endogenous and experimental expression in early chicken embryos

    Matrix Biology 32(7-8):381 (2013)

    Key roles for fibronectin and its integrin receptors have been postulated in the multiple cell-matrix interactions essential for chick embryo morphogenesis. However, mechanistic studies of these processes have been hampered by the current absence of sequence data and chicken cDNA clone...
  17. Regulation of cell adhesion and migration by cell-derived matrices

    Experimental Cell Research 319(16):2434 (2013)

    Three-dimensional in vitro extracellular matrix models provide a physiological alternative to regular two-dimensional cell culture, though they lack the full diversity of molecular composition and physical properties of whole-animal systems. Cell-derived matrices are extracellular matr...
  18. Regulation of cell adhesion and migration by cell-derived matrices.

    Experimental Cell Research 319(16):2434 (2013) PMID 23751565 PMCID PMC3780580

    Three-dimensional in vitro extracellular matrix models provide a physiological alternative to regular two-dimensional cell culture, though they lack the full diversity of molecular composition and physical properties of whole-animal systems. Cell-derived matrices are extracellular matrices that ...
  19. Dimensions in cell migration.

    Current Opinion in Cell Biology 25(5):642 (2013) PMID 23850350 PMCID PMC3758466

    The importance of cell migration for both normal physiological functions and disease processes has been clear for the past 50 years. Although investigations of two-dimensional (2D) migration in regular tissue culture have elucidated many important molecular mechanisms, recent evidence suggests t...
  20. Region-specific epithelial cell dynamics during branching morphogenesis.

    Developmental Dynamics 242(9):1066 (2013) PMID 23780688 PMCID PMC4014777

    Epithelial cells of developing embryonic organs, such as salivary glands, can display substantial motility during branching morphogenesis. Their dynamic movements and molecules involved in their migration are not fully characterized. We generated transgenic mice expressing photo-convertible KikG...