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  1. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon.

    Journal of Cell Biology 154(5):983 (2001) PMID 11524435 PMCID 2196183

    We demonstrate that Tcf3 can inhibit beta-catenin turnover via its competition with axin and adenomatous polyposis for beta-catenin binding. A mutant of beta-catenin that cannot bind Tcf3 is degraded faster than the wild-type protein in Xenopus embryos and extracts. A fragment of beta-catenin and a...
  2. The mechanism of microtubule assembly in vitro

    Journal of Cellular Biochemistry 2(2-4):412 (2004)

  3. Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula

    Development 130(9):1961 (2003)

  4. Polewards chromosome movement driven by microtubule depolymerization in vitro.

    PMID 3340202

    We constructed complexes between isolated chromosomes and microtubules made from purified tubulin to study the movement of chromosomes towards the 'minus' end of microtubules in vitro, a process analogous to the movement of chromosomes towards the pole of the spindle at anaphase of mitosis. Our resu...
  5. Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis.

    PNAS 105(16):6069 (2008) PMID 18420821

    We studied in detail the phosphorylation patterns at a single mitotic state of arrest generated by various antimitotic drugs. We examined the phosphorylation patterns of the APC in HeLa S3 cells after they were arrested in prometaphase with taxol, nocodazole, vincristine, or monastrol. There were 71...
  6. The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm

    Development 130(4):805 (2003)

  7. Dominoes and clocks: the union of two views of the cell cycle.

    Science 246(4930):614 (1989) PMID 2683077

    We review the recent advances in understanding transitions within the cell cycle. These have come from both genetic and biochemical approaches. We discuss the phylogenetic conservation of the mechanisms that induce mitosis and their implications for other transitions in the cell cycle.
  8. Biological implications of microtubule dynamics. FAU - Kirschner, M W

    Harvey lectures 83:1 (1987) PMID 3334137