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  1. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway.

    PLoS Biology 1(1):E10 (2003) PMID 14551908 PMCID PMC212691

    Wnt signaling plays an important role in both oncogenesis and development. Activation of the Wnt pathway results in stabilization of the transcriptional coactivator beta-catenin. Recent studies have demonstrated that axin, which coordinates beta-catenin degradation, is itself degraded. Although t...