1. Orally administered manganese with and without ascorbic acid as a liver-specific contrast agent and bowel marker for magnetic resonance imaging: phase I clinical trial assessing efficacy and safety.

    Investigative Radiology 45(9):559 (2010) PMID 20644487

    The objectives of this clinical trial of orally administered manganese in magnetic resonance imaging (MRI) of the liver were to assess signal enhancements in the liver with and without the addition of an uptake promoter, ascorbic acid, and to evaluate acute safety. A total of 18 healthy adult ma...
  2. Orally administered manganese with and without ascorbic acid as a liver-specific contrast agent and bowel marker for magnetic resonance imaging: phase I clinical trial assessing efficacy and safety.

    Investigative Radiology 45(9):559 (2010) PMID 20644487

    The objectives of this clinical trial of orally administered manganese in magnetic resonance imaging (MRI) of the liver were to assess signal enhancements in the liver with and without the addition of an uptake promoter, ascorbic acid, and to evaluate acute safety. A total of 18 healthy adult ma...
  3. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

    Nature 453(7197):940 (2008) PMID 18509335

    As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and response to treatment. Dynamic nuclear polarization is an emerging technique for substantially increasing the sensitivity of magnetic re...
  4. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

    Nature 453(7197):940 (2008) PMID 18509335

    As alterations in tissue pH underlie many pathological processes, the capability to image tissue pH in the clinic could offer new ways of detecting disease and response to treatment. Dynamic nuclear polarization is an emerging technique for substantially increasing the sensitivity of magnetic re...
  5. Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI.

    Magnetic Resonance in Medicine 59(5):1005 (2008) PMID 18429038

    Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart du...
  6. Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI.

    Magnetic Resonance in Medicine 59(5):1005 (2008) PMID 18429038

    Pyruvate is included in the energy production of the heart muscle and is metabolized into lactate, alanine, and CO(2) in equilibrium with HCO(3) (-). The aim of this study was to evaluate the feasibility of using (13)C hyperpolarization enhanced MRI to monitor pyruvate metabolism in the heart du...
  7. Iodixanol 320 results in better renal tolerance and radiodensity than do gadolinium-based contrast media: arteriography in ischemic porcine kidneys.

    Radiology 247(1):88 (2008) PMID 18292474

    To prospectively compare nephrotoxicity and radiodensity of plasma hyperosmotic gadolinium chelates (attenuation-osmotic ratio of 1:1) with those of plasma iso-osmotic iodine-based contrast media (attenuation-osmotic ratio of 3:1 or 6:1) after renal arteriography in ischemic porcine kidneys. The...
  8. Iodixanol 320 results in better renal tolerance and radiodensity than do gadolinium-based contrast media: arteriography in ischemic porcine kidneys.

    Radiology 247(1):88 (2008) PMID 18292474

    To prospectively compare nephrotoxicity and radiodensity of plasma hyperosmotic gadolinium chelates (attenuation-osmotic ratio of 1:1) with those of plasma iso-osmotic iodine-based contrast media (attenuation-osmotic ratio of 3:1 or 6:1) after renal arteriography in ischemic porcine kidneys. The...
  9. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

    Nature Medicine 13(11):1382 (2007) PMID 17965722

    Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-(13)C]pyruvate that the lactate dehydrogenase-catalyzed flux of (13)C label between the carboxyl groups of...
  10. Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

    Nature Medicine 13(11):1382 (2007) PMID 17965722

    Measurements of early tumor responses to therapy have been shown, in some cases, to predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with hyperpolarized [1-(13)C]pyruvate that the lactate dehydrogenase-catalyzed flux of (13)C label between the carboxyl groups of...
  11. Passive catheter tracking during interventional MRI using hyperpolarized 13C.

    Magnetic Resonance in Medicine 57(6):1140 (2007) PMID 17534914

    Interventional procedures in MRI can be performed preclinically using active or passive catheter-tracking methods. A novel passive nonproton technique is suggested that uses a catheter filled with a hyperpolarized (13)C contrast agent. A prototype three-lumen catheter was built with two closed l...
  12. Passive catheter tracking during interventional MRI using hyperpolarized 13C.

    Magnetic Resonance in Medicine 57(6):1140 (2007) PMID 17534914

    Interventional procedures in MRI can be performed preclinically using active or passive catheter-tracking methods. A novel passive nonproton technique is suggested that uses a catheter filled with a hyperpolarized (13)C contrast agent. A prototype three-lumen catheter was built with two closed l...
  13. Hyperpolarized 13C MRI of the pulmonary vasculature and parenchyma.

    Magnetic Resonance in Medicine 57(3):459 (2007) PMID 17326170

    The study of lung perfusion in normal and diseased subjects is of great interest to physiologists and physicians. In this work we demonstrate the application of a liquid-phase hyperpolarized (HP) carbon-13 ((13)C) tracer to magnetic resonance imaging (MRI) of the pulmonary vasculature and pulmon...
  14. Hyperpolarized 13C MRI of the pulmonary vasculature and parenchyma.

    Magnetic Resonance in Medicine 57(3):459 (2007) PMID 17326170

    The study of lung perfusion in normal and diseased subjects is of great interest to physiologists and physicians. In this work we demonstrate the application of a liquid-phase hyperpolarized (HP) carbon-13 ((13)C) tracer to magnetic resonance imaging (MRI) of the pulmonary vasculature and pulmon...
  15. Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections.

    European Radiology 16(12):2712 (2006) PMID 16896701

    A study was undertaken of the role of osmotoxicity in gadolinium (Gd) and iodine contrast media (CM) nephrotoxicity in ischemic porcine kidneys. Test solutions: mannitol iso-osmotic to 0.5 M: gadopentetate (1.96 Osm/kg H2O), 0.5 M: gadodiamide (0.78 Osm/kg H2O) and 0.5 M: iohexol (190 mg I/ml, 0...
  16. Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections.

    European Radiology 16(12):2712 (2006) PMID 16896701

    A study was undertaken of the role of osmotoxicity in gadolinium (Gd) and iodine contrast media (CM) nephrotoxicity in ischemic porcine kidneys. Test solutions: mannitol iso-osmotic to 0.5 M: gadopentetate (1.96 Osm/kg H2O), 0.5 M: gadodiamide (0.78 Osm/kg H2O) and 0.5 M: iohexol (190 mg I/ml, 0...
  17. Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.

    Cancer Research 66(22):10855 (2006) PMID 17108122

    The "Warburg effect," an elevation in aerobic glycolysis, may be a fundamental property of cancer cells. For cancer diagnosis and treatment, it would be valuable if elevated glycolytic metabolism could be quantified in an image in animals and humans. The pyruvate molecule is at the metabolic cro...
  18. Metabolic imaging by hyperpolarized 13C magnetic resonance imaging for in vivo tumor diagnosis.

    Cancer Research 66(22):10855 (2006) PMID 17108122

    The "Warburg effect," an elevation in aerobic glycolysis, may be a fundamental property of cancer cells. For cancer diagnosis and treatment, it would be valuable if elevated glycolytic metabolism could be quantified in an image in animals and humans. The pyruvate molecule is at the metabolic cro...
  19. Metabolic imaging and other applications of hyperpolarized 13C1.

    Academic Radiology 13(8):932 (2006) PMID 16843845

  20. Metabolic imaging and other applications of hyperpolarized 13C1.

    Academic Radiology 13(8):932 (2006) PMID 16843845