1. STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.

    Neuropathology and Applied Neurobiology 41(3):347 (2015) PMID 24606160

    Insufficient oligodendroglial differentiation of oligodendroglial progenitor cells (OPCs) is suggested to be responsible for remyelination failure and astroglial scar formation in Theiler's murine encephalomyelitis (TME). The aim of the present study is to identify molecular key regulators of OP...
  2. Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist.

    Behavioural Brain Research 277:254 (2015) PMID 24768641

    The neuronal tetraspan proteins, M6A (Gpm6a) and M6B (Gpm6b), belong to the family of proteolipids that are widely expressed in the brain. We recently reported Gpm6a deficiency as a monogenetic cause of claustrophobia in mice. Its homolog proteolipid, Gpm6b, is ubiquitously expressed in neurons ...
  3. Gpm6b deficiency impairs sensorimotor gating and modulates the behavioral response to a 5-HT2A/C receptor agonist.

    Behavioural Brain Research 277:254 (2015) PMID 24768641

    The neuronal tetraspan proteins, M6A (Gpm6a) and M6B (Gpm6b), belong to the family of proteolipids that are widely expressed in the brain. We recently reported Gpm6a deficiency as a monogenetic cause of claustrophobia in mice. Its homolog proteolipid, Gpm6b, is ubiquitously expressed in neurons ...
  4. Brg1-dependent chromatin remodelling is not essentially required during oligodendroglial differentiation.

    Journal of Neuroscience 35(1):21 (2015) PMID 25568100

    Myelinating Schwann cells in the vertebrate peripheral nervous system rely on Brg1 (Smarca4) for terminal differentiation. Brg1 serves as central ATP-hydrolyzing subunit of the chromatin remodelling BAF complexes and is recruited during myelination as part of these complexes by the transcription...
  5. Brg1-Dependent Chromatin Remodelling Is Not Essentially Required during Oligodendroglial Differentiation.

    Journal of Neuroscience 35(1):21 (2015) PMID 25568100

    Myelinating Schwann cells in the vertebrate peripheral nervous system rely on Brg1 (Smarca4) for terminal differentiation. Brg1 serves as central ATP-hydrolyzing subunit of the chromatin remodelling BAF complexes and is recruited during myelination as part of these complexes by the transcription...
  6. Adapting brain metabolism to myelination and long-range signal transduction.

    Glia 62(11):1749 (2014) PMID 25130164

    In the mammalian brain, the subcortical white matter comprises long-range axonal projections and their associated glial cells. Here, astrocytes and oligodendrocytes serve specific functions during development and throughout adult life, when they meet the metabolic needs of long fiber tracts. Wit...
  7. Glial biology in learning and cognition.

    Neuroscientist 20(5):426 (2014) PMID 24122821 PMCID PMC4161624

    Neurons are exquisitely specialized for rapid electrical transmission of signals, but some properties of glial cells, which do not communicate with electrical impulses, are well suited for participating in complex cognitive functions requiring broad spatial integration and long-term temporal reg...
  8. Glial biology in learning and cognition.

    Neuroscientist 20(5):426 (2014) PMID 24122821 PMCID PMC4161624

    Neurons are exquisitely specialized for rapid electrical transmission of signals, but some properties of glial cells, which do not communicate with electrical impulses, are well suited for participating in complex cognitive functions requiring broad spatial integration and long-term temporal reg...
  9. Axons hooked to Schwann cell metabolism.

    Nature Neuroscience 17(10):1293 (2014) PMID 25254976

  10. Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A.

    Nature Medicine 20(9):1055 (2014) PMID 25150498

    Duplication of the gene encoding the peripheral myelin protein of 22 kDa (PMP22) underlies the most common inherited neuropathy, Charcot-Marie-Tooth 1A (CMT1A), a disease without a known cure. Although demyelination represents a characteristic feature, the clinical phenotype of CMT1A is determin...
  11. Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity.

    Cell Reports 8(4):1130 (2014) PMID 25131210

    Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies. To study...
  12. Dysregulated Expression of Neuregulin-1 by Cortical Pyramidal Neurons Disrupts Synaptic Plasticity

    Cell Reports 8(4):1130 (2014)

    Neuregulin-1 (NRG1) gene variants are associated with increased genetic risk for schizophrenia. It is unclear whether risk haplotypes cause elevated or decreased expression of NRG1 in the brains of schizophrenia patients, given that both findings have been reported from autopsy studies...
  13. NF-κB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS.

    Journal of Cell Science 127(Pt 14):3052 (2014) PMID 24860143

    NF-κB is dually involved in neurogenesis and brain pathology. Here, we addressed its role in adult axoneogenesis by generating mutations of RelA (p65) and p50 (also known as NFKB1) heterodimers of canonical NF-κB. In addition to RelA activation in astrocytes, optic nerve axonotmesis caused a hit...
  14. Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases.

    Neuron 83(1):27 (2014) PMID 24991953 PMCID PMC4189115

    Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility genes for diseases such as schizophrenia (SZ) and bipolar disorder. Recent studies have revealed complex Nrg/Erbb si...
  15. Myelination and oligodendrocyte functions in psychiatric diseases.

    JAMA Psychiatry 71(5):582 (2014) PMID 24671770

  16. Progesterone Antagonist Therapy in a Pelizaeus-Merzbacher Mouse Model

    The American Journal of Human Genetics 94(4):533 (2014)

    Pelizaeus-Merzbacher disease (PMD) is a severe hypomyelinating disease, characterized by ataxia, intellectual disability, epilepsy, and premature death. In the majority of cases, PMD is caused by duplication of PLP1 that is expressed in myelinating oligodendrocytes. Despite detailed kn...
  17. Progesterone antagonist therapy in a Pelizaeus-Merzbacher mouse model.

    The American Journal of Human Genetics 94(4):533 (2014) PMID 24680886 PMCID PMC3980417

    Pelizaeus-Merzbacher disease (PMD) is a severe hypomyelinating disease, characterized by ataxia, intellectual disability, epilepsy, and premature death. In the majority of cases, PMD is caused by duplication of PLP1 that is expressed in myelinating oligodendrocytes. Despite detailed knowledge of...
  18. Profilin 1 is required for peripheral nervous system myelination.

    Development 141(7):1553 (2014) PMID 24598164

    Myelination allows rapid saltatory propagation of action potentials along the axon and is an essential prerequisite for the normal functioning of the nervous system. During peripheral nervous system (PNS) development, myelin-forming Schwann cells (SCs) generate radial lamellipodia to sort and en...
  19. Profilin 1 is required for peripheral nervous system myelination.

    Development 141(7):1553 (2014) PMID 24598164

    Myelination allows rapid saltatory propagation of action potentials along the axon and is an essential prerequisite for the normal functioning of the nervous system. During peripheral nervous system (PNS) development, myelin-forming Schwann cells (SCs) generate radial lamellipodia to sort and en...
  20. NEUROPSYCHIATRIC DISEASE RELEVANCE OF CIRCULATING ANTI-NMDA RECEPTOR AUTOANTIBODIES DEPENDS ON BLOOD BRAIN BARRIER INTEGRITY

    Schizophrenia Research 153:S35 (2014)