Serum IgG titres, but not avidity, correlates with neutralizing antibody response after H5N1 vaccination.
Vaccine 32(35):4550 (2014)
Influenza H5N1 virus constitutes a pandemic threat and development of effective H5N1 vaccines is a global priority. Anti-influenza antibodies directed towards the haemagglutinin (HA) define a correlate of protection. Both antibody concentration and avidity may be important for virus neutralizati...
Reply to Sambhara.
Journal of Infectious Diseases 207(7):1186 (2013)
A(H1N1)pdm09 vaccination of health care workers: improved immune responses in low responders following revaccination.
Journal of Infectious Diseases 206(11):1660 (2012)
We conducted a clinical trial in October 2009 to evaluate the immunogenicity of the AS03-adjuvanted influenza vaccine (pH1N1 vaccine) in health care workers (HCWs). By 2 weeks after vaccination, 97% had protective hemagglutinin inhibition (HI) titers (≥ 40) however, 16% were low responders (LR) ...
Short- and long-term efficacy of intra-articular injections with betamethasone as part of a treat-to-target strategy in early rheumatoid arthritis: impact of joint area, repeated injections, MRI findings, anti-CCP, IgM-RF and CRP.
Annals of the Rheumatic Diseases 71(6):851 (2012)
To investigate the short-term and long-term efficacy of intra-articular betamethasone injections, and the impact of joint area, repeated injections, MRI pathology, anticyclic citrullinated peptide (CCP) and immunoglobulin M rheumatoid factor (IgM-RF) status in patients with early rheumatoid arth...
[Lymphoma suspected cervical lymph node inflammation indicating secondary syphilis].
Ugeskrift for laeger 174(20):1368 (2012)
We report a case of a 45 year-old bisexual male with multiple enlarged cervical and inguinal lymph nodes. Malignant lymphoma was suspected. Initial fine needle aspirations and the following extirpation of a cervical lymph node revealed severe chronic inflammation. However, thorough blood screeni...
Evaluation of the sublingual route for administration of influenza H5N1 virosomes in combination with the bacterial second messenger c-di-GMP.
PLoS ONE 6(11):e26973 (2011)
Avian influenza A H5N1 is a virus with pandemic potential. Mucosal vaccines are attractive as they have the potential to block viruses at the site of entry, thereby preventing both disease and further transmission. The intranasal route is safe for the administration of seasonal live-attenuated i...
Uncoupling of collagen II metabolism in newly diagnosed, untreated rheumatoid arthritis is linked to inflammation and antibodies against cyclic citrullinated peptides.
Journal of Rheumatology 37(6):1113 (2010)
To investigate the relationship between markers of collagen II synthesis and degradation with disease activity measures, autoantibodies, and radiographic outcomes in a 4-year protocol on patients with early rheumatoid arthritis (RA) who are naïve to disease-modifying antirheumatic drugs.
Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis.
Arthritis research & therapy 12(2):R39 (2010)
Surfactant protein D (SP-D) is a collectin with immuno-regulatory functions, which may depend on oligomerization. Anti-microbial and anti-inflammatory properties have been attributed to multimeric SP-D variants, while trimeric subunits per se have been suggested to enhance inflammation. Previous...
Mannose-binding lectin gene polymorphisms are associated with disease activity and physical disability in untreated, anti-cyclic citrullinated peptide-positive patients with early rheumatoid arthritis.
Journal of Rheumatology 36(4):731 (2009)
To study the association between polymorphisms in the mannose-binding lectin gene (MBL2) and disease activity, physical disability, and joint erosions in patients with newly diagnosed rheumatoid arthritis (RA).
Patients with early RA (n=158) not previously treated with disease modifying antirheu...
Searching for decaying axionlike dark matter from clusters of galaxies.
Physical Review Letters 99(13):131301 (2007)
We constrain the lifetime of radiatively decaying dark matter in clusters of galaxies inspired by generic Kaluza-Klein axions, which have been invoked as a possible explanation for the solar coronal x-ray emission. These particles can be produced inside stars and remain confined by the gravitati...
Combination treatment with methotrexate, cyclosporine, and intraarticular betamethasone compared with methotrexate and intraarticular betamethasone in early active rheumatoid arthritis: an investigator-initiated, multicenter, randomized, double-blind, parallel-group, placebo-controlled study.
Arthritis & Rheumatism 54(5):1401 (2006)
To investigate whether disease control can be achieved in early active rheumatoid arthritis (RA) by treatment with methotrexate and intraarticular betamethasone, and whether the addition of cyclosporine to the regimen has any additional effect.
Patients (n = 160) were randomized to receive metho...
Discovery of a very extended X-ray halo around a quiescent spiral galaxy – The “missing link” of galaxy formation
New Astronomy 11(7):465 (2006)
Hot gaseous haloes surrounding galaxies and extending well beyond the distribution of stars are a ubiquitous prediction of galaxy formation scenarios. The haloes are believed to consist of gravitationally trapped gas with a temperature of millions of Kelvin. The existence of such hot haloes...
The optical afterglow of the short gamma-ray burst GRB 050709.
Nature 437(7060):859 (2005)
It has long been known that there are two classes of gamma-ray bursts (GRBs), mainly distinguished by their durations. The breakthrough in our understanding of long-duration GRBs (those lasting more than approximately 2 s), which ultimately linked them with energetic type Ic supernovae, came fro...
Selective posterior cerebral artery amobarbital test: its role in presurgical memory assessment in temporal lobe epilepsy.
Epilepsia 45(7):817 (2004)
To evaluate the efficacy and risk of complications of selective posterior cerebral artery (PCA) amobarbital anesthesia in memory assessment of patients with epilepsy under consideration for temporal lobe resection.
Thirty-two candidates for temporal lobectomy in whom conclusive memory assessment...
Small-scale variations in the radiating surface of theGRB 011211jet
New Astronomy 9(6):435 (2004)
We report the discovery of the afterglow of the X-ray rich, long-duration γ-ray burst
GRB 011211 and present evidence for oscillatory behaviour in its early optical light curve. The time-scale of the fluctuations, ∼1 h, is much smaller than the time of the observations, ∼12 h from th...
A very energetic supernova associated with the gamma-ray burst of 29 March 2003.
Nature 423(6942):847 (2003)
Over the past five years evidence has mounted that long-duration (>2 s) gamma-ray bursts (GRBs)-the most luminous of all astronomical explosions-signal the collapse of massive stars in our Universe. This evidence was originally based on the probable association of one unusual GRB with a supernov...
Coronary arteriography with an oxygenated contrast medium: Cardiac effects in dogs with and without acute ischemic heart failure
Academic Radiology 3(6):493 (1996)
Rationale and Objectives.
We investigated the possible cardiac effects of oxygen addition to contrast media (CM) during coronary arteriography in dogs that did and did not have ischemic heart failure.
Imaging routines for the esophagus, small bowel, abdomen, and liver in six Norwegian hospitals from 1975 to 1993
Clinical Imaging 20(4):256 (1996)
The roles of liver scintigraphy in addition to other imaging modalities of the esophagus and the small bowel and the use of abdominal flat films were studied in six Norwegian hospitals between 1975 and 1993. Parallel to the introduction of ultrasonography, the use of liver scintigraphy disa...
Academic Radiology 3(9):783 (1996)
Additive hemodynamic and electrophysiologic effects of repeated intracoronary contrast media injections in dogs with heart failure
Academic Radiology 2(11):973 (1995)
Rationale and Objectives.
We investigated the cardiac effects of single and repeated contrast media injections in dogs with heart failure and compared the effects of iohexol with iohexol supplemented with electrolytes (30 mmol/l NaCl, 0.15 mmol/l CaCl2, 0.9 mmol/l KCl, and 0.1 mmol/l M...