1. Tolerance signatures in transplant recipients.

    Current Opinion in Organ Transplantation 20(4):400 (2015) PMID 26107969

    The intent of this review was to describe biomarkers that predict or identify individuals who exhibit tolerance to a transplanted organ. The identification of tolerance biomarkers would spare some individuals the toxicity of immunosuppressive agents, enhance the safety of studies to induce toler...
  2. Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response.

    Journal of Allergy and Clinical Immunology 135(4):913 (2015) PMID 25457150

    Immunotherapy inhibits basophil histamine release, but the assay is cumbersome, and no one has studied the effects of immunotherapy withdrawal. Intracellular fluorochrome-labeled diamine oxidase (DAO) was used as a novel functional readout of basophil histamine release after immunotherapy. Resul...
  3. Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation.

    Science Translational Medicine 7(280):280rv2 (2015) PMID 25810312 PMCID PMC4425354

    Although major advances have been made in solid organ and hematopoietic stem cell transplantation in the last 50 years, big challenges remain. This review outlines the current immunological limitations for hematopoietic stem cell and solid organ transplantation and discusses new immune-modulatin...
  4. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

    Nature Immunology 16(2):188 (2015) PMID 25559257 PMCID PMC4297515

    Foxp3(+) regulatory T cells (Treg cells) are required for immunological homeostasis. One notable distinction between conventional T cells (Tconv cells) and Treg cells is differences in the activity of phosphatidylinositol-3-OH kinase (PI(3)K); only Tconv cells downregulate PTEN, the main negativ...
  5. T-cell energy metabolism as a controller of cell fate in transplantation.

    Current Opinion in Organ Transplantation 20(1):21 (2015) PMID 25563988

    To highlight some of the recent developments in the novel field of immunometabolism and the therapeutic potential of the many regulatory components of this immunometabolic network for transplantation. In response to cytokines, changes in nutrients, and other alterations in the local milieu, immu...
  6. T-cell energy metabolism as a controller of cell fate in transplantation.

    Current Opinion in Organ Transplantation 20(1):21 (2015) PMID 25563988 PMCID PMC4387772

    To highlight some of the recent developments in the novel field of immunometabolism and the therapeutic potential of the many regulatory components of this immunometabolic network for transplantation. In response to cytokines, changes in nutrients, and other alterations in the local milieu, immu...
  7. T-cell energy metabolism as a controller of cell fate in transplantation.

    Current Opinion in Organ Transplantation 20(1):21 (2015) PMID 25563988

    To highlight some of the recent developments in the novel field of immunometabolism and the therapeutic potential of the many regulatory components of this immunometabolic network for transplantation. In response to cytokines, changes in nutrients, and other alterations in the local milieu, immu...
  8. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability.

    Nature Immunology 16(2):188 (2015) PMID 25559257 PMCID PMC4297515

    Foxp3(+) regulatory T cells (Treg cells) are required for immunological homeostasis. One notable distinction between conventional T cells (Tconv cells) and Treg cells is differences in the activity of phosphatidylinositol-3-OH kinase (PI(3)K); only Tconv cells downregulate PTEN, the main negativ...
  9. Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity.

    Blood 125(5):852 (2015) PMID 25477498

    Mice with T-cell-specific loss of the tumor suppressor gene PTEN early in T-cell ontogeny develop thymic lymphomas that invariably harbor a reciprocal translocation involving the T-cell receptor α/δ locus and c-myc, t(14;15). In addition to its known function as a lipid phosphatase opposing PI3K...
  10. Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity.

    Blood 125(5):852 (2015) PMID 25477498

    Mice with T-cell-specific loss of the tumor suppressor gene PTEN early in T-cell ontogeny develop thymic lymphomas that invariably harbor a reciprocal translocation involving the T-cell receptor α/δ locus and c-myc, t(14;15). In addition to its known function as a lipid phosphatase opposing PI3K...
  11. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

    Journal of Clinical Investigation 125(1):194 (2015) PMID 25437876

    Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific metabolic differences that modify T cell populations are uncertain. Here, w...
  12. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

    Journal of Clinical Investigation 125(1):194 (2015) PMID 25437876

    Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific metabolic differences that modify T cell populations are uncertain. Here, w...
  13. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

    Journal of Clinical Investigation 125(1):194 (2015) PMID 25437876

    Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific metabolic differences that modify T cell populations are uncertain. Here, w...
  14. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

    Journal of Clinical Investigation 125(1):194 (2015) PMID 25437876 PMCID PMC4382238

    Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17) and Treg subsets are metabolically distinct, yet the specific metabolic differences that modify T cell populations are uncertain. Here, w...
  15. Homeostatic expansion as a barrier to lymphocyte depletion strategies.

    Current Opinion in Organ Transplantation 19(4):357 (2014) PMID 24926701

    Following lymphodepletion, lymphocytes repopulate the immune space both through enhanced thymopoiesis and proliferation of residual nondepleted peripheral lymphocytes. The term homeostatic proliferation (alternatively homeostatic expansion or lymphopenia-induced proliferation) refers to the latt...
  16. Homeostatic expansion as a barrier to lymphocyte depletion strategies.

    Current Opinion in Organ Transplantation 19(4):357 (2014) PMID 24926701 PMCID PMC4476295

    Following lymphodepletion, lymphocytes repopulate the immune space both through enhanced thymopoiesis and proliferation of residual nondepleted peripheral lymphocytes. The term homeostatic proliferation (alternatively homeostatic expansion or lymphopenia-induced proliferation) refers to the latt...
  17. Homeostatic expansion as a barrier to lymphocyte depletion strategies.

    Current Opinion in Organ Transplantation 19(4):357 (2014) PMID 24926701

    Following lymphodepletion, lymphocytes repopulate the immune space both through enhanced thymopoiesis and proliferation of residual nondepleted peripheral lymphocytes. The term homeostatic proliferation (alternatively homeostatic expansion or lymphopenia-induced proliferation) refers to the latt...
  18. Tolerance: one transplant for life.

    Transplantation 98(2):117 (2014) PMID 24926829 PMCID PMC4101034

    Recently, The Transplantation Society convened a workshop to address the question, "What do we need to have in place to make tolerance induction protocols a 'standard of care' for organ transplant recipients over the next decade?" In a productive 2-day meeting, there was wide-ranging discussion ...
  19. Tolerance: one transplant for life.

    Transplantation 98(2):117 (2014) PMID 24926829 PMCID PMC4101034

    Recently, The Transplantation Society convened a workshop to address the question, "What do we need to have in place to make tolerance induction protocols a 'standard of care' for organ transplant recipients over the next decade?" In a productive 2-day meeting, there was wide-ranging discussion ...
  20. B cells with immune-regulating function in transplantation.

    Nature Reviews: Nephrology 10(7):389 (2014) PMID 24846332

    In transplantation, the contribution of B cells to the rejection or acceptance of the allograft is a topic of major interest. The presence of donor-specific antibodies in transplant recipients is often associated with decreased graft function and rejection, clearly indicating a pathogenetic role...