1. CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: a smoking gun?

    Biochimica et Biophysica Acta 1838(2):643 (2014) PMID 23732235

    The CLIC proteins are a highly conserved family of metazoan proteins with the unusual ability to adopt both soluble and integral membrane forms. The physiological functions of CLIC proteins may include enzymatic activity in the soluble form and anion channel activity in the integral membrane for...
  2. CLIC proteins, ezrin, radixin, moesin and the coupling of membranes to the actin cytoskeleton: a smoking gun?

    Biochimica et Biophysica Acta 1838(2):643 (2014) PMID 23732235

    The CLIC proteins are a highly conserved family of metazoan proteins with the unusual ability to adopt both soluble and integral membrane forms. The physiological functions of CLIC proteins may include enzymatic activity in the soluble form and anion channel activity in the integral membrane for...
  3. The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.

    PLoS ONE 9(6):e100370 (2014) PMID 24971956 PMCID PMC4074070

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15) modulates food intake and body weight under physiological and pathological conditions by acting on the hypothalamus and brainstem. When overexpressed in disease, such as in advanced cancer, elevated serum MIC-1/GDF15 levels lead to an anorexia/cache...
  4. The anorectic actions of the TGFβ cytokine MIC-1/GDF15 require an intact brainstem area postrema and nucleus of the solitary tract.

    PLoS ONE 9(6):e100370 (2014) PMID 24971956 PMCID PMC4074070

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15) modulates food intake and body weight under physiological and pathological conditions by acting on the hypothalamus and brainstem. When overexpressed in disease, such as in advanced cancer, elevated serum MIC-1/GDF15 levels lead to an anorexia/cache...
  5. Should bioprostheses be considered the valve of choice for dialysis-dependent patients?

    Journal of Cardiothoracic Surgery 8:42 (2013) PMID 23497614 PMCID PMC3606457

    There is controversy regarding the choice of prosthetic valves in patients with cardiac valve disease and dialysis-dependent patients. This review assesses a 12-year experience and outcomes after valve replacement in patients on chronic preoperative renal dialysis, comparing survival and valve-r...
  6. TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

    PLoS ONE 8(2):e55174 (2013) PMID 23468844 PMCID PMC3585300

    The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, b...
  7. TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

    PLoS ONE 8(2):e55174 (2013) PMID 23468844 PMCID PMC3585300

    The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, b...
  8. Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15.

    Journal of Cachexia Sarcopenia and Muscle 3(4):239 (2012) PMID 22936174 PMCID PMC3505580

    Anorexia/cachexia is a common and currently mostly untreatable complication of advanced cancer. It is also a feature of a number of chronic diseases and can also occur as part of the normal ageing process. Over recent years, two different, but sometimes overlapping, processes have been identifie...
  9. Anorexia/cachexia of chronic diseases: a role for the TGF-β family cytokine MIC-1/GDF15.

    Journal of Cachexia Sarcopenia and Muscle 3(4):239 (2012) PMID 22936174 PMCID PMC3505580

    Anorexia/cachexia is a common and currently mostly untreatable complication of advanced cancer. It is also a feature of a number of chronic diseases and can also occur as part of the normal ageing process. Over recent years, two different, but sometimes overlapping, processes have been identifie...
  10. Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification.

    Journal of Cell Science 125(Pt 22):5479 (2012) PMID 22956539 PMCID PMC3561857

    Intracellular chloride channel protein 1 (CLIC1) is a 241 amino acid protein of the glutathione S transferase fold family with redox- and pH-dependent membrane association and chloride ion channel activity. Whilst CLIC proteins are evolutionarily conserved in Metazoa, indicating an important rol...
  11. Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification.

    Journal of Cell Science 125(Pt 22):5479 (2012) PMID 22956539 PMCID PMC3561857

    Intracellular chloride channel protein 1 (CLIC1) is a 241 amino acid protein of the glutathione S transferase fold family with redox- and pH-dependent membrane association and chloride ion channel activity. Whilst CLIC proteins are evolutionarily conserved in Metazoa, indicating an important rol...
  12. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease.

    Nephrology Dialysis Transplantation 27(1):70 (2012) PMID 21940482

    Elevated macrophage inhibitory cytokine-1 (MIC-1/GDF15) levels in serum mediate anorexia and weight loss in some cancer patients and similarly elevated levels occur in chronic kidney disease (CKD). Serum MIC-1/GDF15 is also elevated in chronic inflammatory diseases and predicts atherosclerotic e...
  13. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice.

    PLoS ONE 7(8):e43833 (2012) PMID 22952779 PMCID PMC3428289

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15), a divergent member of the TGF-β superfamily, is over-expressed by many common cancers including those of the prostate (PCa) and its expression is linked to cancer outcome. We have evaluated the effect of MIC-1/GDF15 overexpression on PCa developmen...
  14. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease.

    Nephrology Dialysis Transplantation 27(1):70 (2012) PMID 21940482

    Elevated macrophage inhibitory cytokine-1 (MIC-1/GDF15) levels in serum mediate anorexia and weight loss in some cancer patients and similarly elevated levels occur in chronic kidney disease (CKD). Serum MIC-1/GDF15 is also elevated in chronic inflammatory diseases and predicts atherosclerotic e...
  15. Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice.

    PLoS ONE 7(8):e43833 (2012) PMID 22952779 PMCID PMC3428289

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15), a divergent member of the TGF-β superfamily, is over-expressed by many common cancers including those of the prostate (PCa) and its expression is linked to cancer outcome. We have evaluated the effect of MIC-1/GDF15 overexpression on PCa developmen...
  16. The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism.

    Growth Factors 29(5):187 (2011) PMID 21831009

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis and prognosis of cancer and vascular disease. Furthermore, its serum levels are a powerful predictor of all-cause m...
  17. The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism.

    Growth Factors 29(5):187 (2011) PMID 21831009

    Macrophage inhibitory cytokine-1 (MIC-1/GDF15) is associated with cardiovascular disease, inflammation, body weight regulation and cancer. Its serum levels facilitate the diagnosis and prognosis of cancer and vascular disease. Furthermore, its serum levels are a powerful predictor of all-cause m...
  18. PS1-090 The role of the TGF-βsuperfamily cytokine MIC-1/GDF15 in biology and medicine

    Cytokine 56(1):40 (2011)

  19. PS1-090 The role of the TGF-βsuperfamily cytokine MIC-1/GDF15 in biology and medicine

    Cytokine 56(1):40 (2011)

  20. The TGF-beta superfamily cytokine MIC-1/GDF15: secretory mechanisms facilitate creation of latent stromal stores.

    Journal of Interferon & Cytokine Research 30(6):389 (2010) PMID 20187768

    Macrophage inhibitory cytokine-1/growth differentiation factor 15 (MIC-1/GDF15), a divergent member of the TGF-beta superfamily is induced by a range of proinflammatory cytokines and oxidized low-density lipoprotein (oxLDL) and is highly expressed in macrophages in atherosclerotic and tumor lesi...