LINC00472 expression is regulated by promoter methylation and associated with disease-free survival in patients with grade 2 breast cancer.
Breast Cancer Research and Treatment 154(3):473 (2015)
Long non-coding RNAs (lncRNAs) are a class of newly recognized DNA transcripts that have diverse biological activities. Dysregulation of lncRNAs may be involved in many pathogenic processes including cancer. Recently, we found an intergenic lncRNA, LINC00472, whose expression was correlated with...
A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1.
Humangenetik 134(11-12):1249 (2015)
Over 50 loci associated with colorectal cancer (CRC) have been uncovered by genome-wide association studies (GWAS). Identifying additional loci has the potential to help elucidate aspects of the underlying biological processes leading to better understanding of the pathogenesis of the disease. W...
Circulating Unsaturated Fatty Acids Delineate the Metabolic Status of Obese Individuals.
EBioMedicine 2(10):1513 (2015)
Obesity is not a homogeneous condition across individuals since about 25-40% of obese individuals can maintain healthy status with no apparent signs of metabolic complications. The simple anthropometric measure of body mass index does not always reflect the biological effects of excessive body f...
Mutated Fanconi anemia pathway in non-Fanconi anemia cancers.
Oncotarget 6(24):20396 (2015)
An extremely high cancer incidence and the hypersensitivity to DNA crosslinking agents associated with Fanconi Anemia (FA) have marked it to be a unique genetic model system to study human cancer etiology and treatment, which has emerged an intense area of investigation in cancer research. Howev...
Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer.
Oncotarget 6(11):8579 (2015)
LINC00472 is a novel long intergenic non-coding RNA. We evaluated LINC00472 expression in breast tumor samples using RT-qPCR, performed a meta-analysis of over 20 microarray datasets from the Gene Expression Omnibus (GEO) database, and investigated the effect of LINC00472 expression on cell prol...
Differences in IGF-axis protein expression and survival among multiethnic breast cancer patients.
Cancer Medicine 4(3):354 (2015)
There is limited knowledge about the biological basis of racial/ethnic disparities in breast cancer outcomes. Aberrations in IGF signaling induced by obesity and other factors may contribute to these disparities. This study examines the expression profiles of the insulin-like growth factor (IGF)...
In silico functional pathway annotation of 86 established prostate cancer risk variants.
PLoS ONE 10(2):e0117873 (2015)
Heritability is one of the strongest risk factors of prostate cancer, emphasizing the importance of the genetic contribution towards prostate cancer risk. To date, 86 established prostate cancer risk variants have been identified by genome-wide association studies (GWAS). To determine if these r...
Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.
Nature Communications 5:4613 (2014)
The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identi...
Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.
Genes, Chromosomes and Cancer 52(5):450 (2013)
Microsatellite stable (MSS), CpG island methylator phenotype (CIMP)-negative colorectal tumors, the most prevalent molecular subtype of colorectal cancer, are associated with extensive copy number alteration (CNA) events and aneuploidy. We report on the identification of characteristic recurrent...
cis-Expression QTL analysis of established colorectal cancer risk variants in colon tumors and adjacent normal tissue.
PLoS ONE 7(2):e30477 (2012)
Genome-wide association studies (GWAS) have identified 19 risk variants associated with colorectal cancer. As most of these risk variants reside outside the coding regions of genes, we conducted cis-expression quantitative trait loci (cis-eQTL) analyses to investigate possible regulatory functio...
Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women.
Breast Cancer Research and Treatment 127(1):297 (2011)
Genomic copy number alterations (CNA) are common in breast cancer. Identifying characteristic CNAs associated with specific breast cancer subtypes is a critical step in defining potential mechanisms of disease initiation and progression. We used genome-wide array comparative genomic hybridizatio...
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster.
Molecular and Cellular Biology 25(16):7078 (2005)
The Myc-Max-Mad/Mnt network of transcription factors has been implicated in oncogenesis and the regulation of proliferation in vertebrate cells. The identification of Myc and Max homologs in Drosophila melanogaster has demonstrated a critical role for dMyc in cell growth control. In this report,...
Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes.
Cancer Research 64(23):8541 (2004)
In this study, we performed high-resolution array comparative genomic hybridization with an array of 4153 bacterial artificial chromosome clones to assess copy number changes in 44 archival breast cancers. The tumors were flow sorted to exclude non-tumor DNA and increase our ability to detect ge...
dMyc is required for larval growth and endoreplication in Drosophila.
Development 131(10):2317 (2004)
Members of the Myc family of proto-oncogenes have long been implicated in regulating proliferation, apoptosis and oncogenesis. Recently, transcriptional and biological studies have suggested a direct role for Myc in regulating growth. We have used dm(4), a new null allele of the Drosophila dimin...
Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.
Genes & Development 17(9):1101 (2003)
The Myc/Max/Mad transcription factor network is critically involved in cell behavior; however, there is relatively little information on its genomic binding sites. We have employed the DamID method to carry out global genomic mapping of the Drosophila Myc, Max, and Mad/Mnt proteins. Each protein...