Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Nature Genetics 48(8):970 (2016)
Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.
The American Journal of Human Genetics 99(1):8 (2016)
Red blood cell (RBC) traits are important heritable clinical biomarkers and modifiers of disease severity. To identify coding genetic variants associated with these traits, we conducted meta-analyses of seven RBC phenotypes in 130,273 multi-ethnic individuals from studies genotyped on an exome a...
Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.
The American Journal of Human Genetics 99(1):40 (2016)
Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts,...
Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases.
The American Journal of Human Genetics 99(1):22 (2016)
White blood cells play diverse roles in innate and adaptive immunity. Genetic association analyses of phenotypic variation in circulating white blood cell (WBC) counts from large samples of otherwise healthy individuals can provide insights into genes and biologic pathways involved in production...
Mortality in Older Persons with Retinopathy and Concomitant Health Conditions: The Age, Gene/Environment Susceptibility-Reykjavik Study.
Ophthalmology 123(7):1570 (2016)
To assess the impact of retinopathy on mortality in older persons with concomitant health conditions.
Population-based prospective cohort study.
A total of 4966 individuals aged 67 to 96 years (43.2% were male) from the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-RS).
Comparison of non-invasive MRI measurements of cerebral blood flow in a large multisite cohort.
Journal of Cerebral Blood Flow and Metabolism 36(7):1244 (2016)
Arterial spin labeling and phase contrast magnetic resonance imaging provide independent non-invasive methods for measuring cerebral blood flow. We compared global cerebral blood flow measurements obtained using pseudo-continuous arterial spin labeling and phase contrast in 436 middle-aged subje...
Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals.
Alzheimer's & Dementia 12(7):815 (2016)
Recently, quantitative metabolomics identified a panel of 10 plasma lipids that were highly predictive of conversion to Alzheimer's disease (AD) in cognitively normal older individuals (n = 28, area under the curve [AUC] = 0.92, sensitivity/specificity of 90%/90%).
Quantitative targeted metabolo...
Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial.
JAMA 315(24):2673 (2016)
The appropriate treatment target for systolic blood pressure (SBP) in older patients with hypertension remains uncertain.
To evaluate the effects of intensive (<120 mm Hg) compared with standard (<140 mm Hg) SBP targets in persons aged 75 years or older with hypertension but without diabetes.
Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease.
Journal of Alzheimer's Disease 53(3):921 (2016)
Effective prevention of Alzheimer's disease (AD) requires the development of risk prediction tools permitting preclinical intervention. We constructed a genetic risk score (GRS) comprising common genetic variants associated with AD, evaluated its association with incident AD and assessed its cap...
Changes in Frailty Predict Changes in Cognition in Older Men: The Honolulu-Asia Aging Study.
Journal of Alzheimer's Disease 53(3):1003 (2016)
As cognitive decline mostly occurs in late life, where typically it co-exists with many other ailments, it is important to consider frailty in understanding cognitive change.
Here, we examined the association of change in frailty status with cognitive trajectories in a well-studied cohort of old...
Brain MRI Volume Findings in Diabetic Adults With Albuminuria: The ACCORD-MIND Study.
Journals of Gerontology Series A: Biological Sc... 71(6):803 (2016)
Albuminuria is associated with cognitive impairment in people with type 2 diabetes mellitus (T2DM). The brain volume correlates of albuminuria in people with T2DM have not been well investigated.
We examined 502 individuals with T2DM (9-12 years duration; mean age ~62 years) who had a brain MRI ...
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Nature Genetics 48(6):624 (2016)
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conduc...
Genome-wide association study identifies 74 loci associated with educational attainment.
Nature 533(7604):539 (2016)
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends...
Systemic right-to-left shunts, ischemic brain lesions, and persistent migraine activity.
Neurology 86(18):1668 (2016)
To assess whether migraine in the general population is associated with increased risk of systemic right-to-left shunts (RLS) and whether RLS are associated with increased prevalence of brain infarcts and persistent recurrence of migraine attacks at older age.
Brain MRI and transcranial Doppler ...
Daily Physical Activity And Mortality Risk In The Very Old: Age, Gene/Environment-Reykjavik Study: 1993 Board #145 June 2, 3: 30 PM - 5: 00 PM.
Medicine & Science in Sports & Exercise 48(5 Suppl 1):555 (2016)
Late-life brain volume: a life-course approach. The AGES-Reykjavik study.
Neurobiology of Aging 41:86 (2016)
The "fetal-origins-of-adult-disease" hypothesis proposes that an unfavorable intrauterine environment, estimated from small birth size, may induce permanent changes in fetal organs, including the brain. These changes in combination with effects of (cardiovascular) exposures during adult life may...
Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study.
Journal of Psychiatry and Neuroscience 41(3):162 (2016)
Arterial stiffness may contribute to depression via cerebral microvascular damage, but evidence for this is scarce. We therefore investigated whether arterial stiffness is associated with depressive symptoms and whether cerebral small vessel disease contributes to this association.
The Association Between Midlife Physical Activity and Depressive Symptoms in Late Life: Age Gene/Environment Susceptibility-Reykjavik Study.
Journals of Gerontology Series A: Biological Sc... 71(4):502 (2016)
There is little evidence on the long-term association between physical activity (PA) and depressive symptoms in old age. We examined the association of midlife PA and depressive symptoms in late life.
A large community-based population residing in Reykjavik, Iceland, participated in a longitudin...
High-Sensitivity Cardiac Troponin I Is a Strong Predictor of Cardiovascular Events and Mortality in the AGES-Reykjavik Community-Based Cohort of Older Individuals.
Clinical Chemistry 62(4):623 (2016)
The objective of this study was to investigate the predictive power of a high-sensitivity cardiac troponin I (hs-cTnI) assay for cardiovascular events and mortality in a large population of older community dwellers.
Blood was collected from 5764 individuals (age 66-98 years) during the period of...
White matter hyperintensities and imaging patterns of brain ageing in the general population.
Brain 139(Pt 4):1164 (2016)
White matter hyperintensities are associated with increased risk of dementia and cognitive decline. The current study investigates the relationship between white matter hyperintensities burden and patterns of brain atrophy associated with brain ageing and Alzheimer's disease in a large populatis...